{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE348nnn/GSE348257/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Rattus norvegicus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE348257"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptome profiling of the spinal dorsal horn in a rat bone cancer pain model (Sham vs. BCP, part of a study on dexmedetomidine and the Nrf2/Slc7a11/ferroptosis pathway)","description":"Bone cancer pain (BCP) is a major source of cancer-related suffering and is difficult to manage with opioid-based therapy. This dataset contains bulk RNA-seq data of the spinal dorsal horn from a rat BCP model, generated as part of a study investigating whether dexmedetomidine alleviates BCP by inhibiting spinal ferroptosis via the Nrf2/SLC7A11 pathway. BCP was induced by injecting Walker 256 mammary gland carcinoma cells into the left tibial bone marrow cavity of female Sprague-Dawley rats; sham-operated rats receiving inactivated Walker 256 cells served as controls (n = 3 per group). Spinal dorsal horn tissues were collected 15 days after inoculation. Compared with the sham group, 1072 genes were differentially expressed in the BCP group (848 up-regulated and 224 down-regulated; |log2 fold change| > 0.5, P < 0.05), with Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showing significant enrichment of the ferroptosis pathway. These data identify ferroptosis as a core pathogenic pathway in the spinal dorsal horn of BCP rats. Funding: Suzhou Applied Basic Research (medical and health) Science and Technology Innovation Project (SYWD2024090).","dates":{"publication":"2026/09/25"},"accession":"GSE348257","cross_references":{"GSM":["GSM10069138","GSM10069137","GSM10069139","GSM10069141","GSM10069140","GSM10069142"],"GPL":["18694"],"GSE":["348257"],"taxon":["Rattus norvegicus"]}}