GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE348nnn/GSE348676/primary200OKTranscriptomicsHomo sapiens Genome binding/occupancy profiling by high throughput sequencingExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE348676GEOGSEfalseSTAT3 controls IL-6-induced epigenomic remodeling and restrains a latent STAT1-associated interferon program in human macrophagesThis SuperSeries comprises transcriptomic and epigenomic datasets generated in human macrophages to investigate IL-6-STAT3 signaling. The datasets include RNA-seq under STAT3 degradation and JAK inhibition, IL-6 time-course RNA-seq, hMDM RNA-seq, ATAC-seq, and CUT&Tag profiling of H3K27ac, STAT3, and STAT1. Together, these data characterize IL-6-induced chromatin and transcriptional changes and the roles of STAT3 and STAT1 in macrophage inflammatory programs. This SuperSeries is composed of the SubSeries listed below.2026/09/28GSE348676GSM9184664GSM9184663GSM9184662GSM9184661GSM9184660GSM9184659GSM9184658GSM9184657GSM9184656GSM9184655GSM9184654GSM9184631GSM9184630GSM9184628GSM9184627GSM9184626GSM9184669GSM9184668GSM9184667GSM9184666GSM9184665GSM10068959GSM9184629GSM9184642GSM9184641GSM9184640GSM10068962GSM9184639GSM9184638GSM10068961GSM9184637GSM10068960GSM9184636GSM10068966GSM9184635GSM9184634GSM10068965GSM9184633GSM10068964GSM10068963GSM9184632GSM10068969GSM10068968GSM10068967GSM9184653GSM9184652GSM9184651GSM9184650GSM10068973GSM10068972GSM9184649GSM9184648GSM10068971GSM10068970GSM9184647GSM9184646GSM9184645GSM9184644GSM9184643GSM1006897416791207952467634281348676Homo sapiens