{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE349nnn/GSE349044/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE349044"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Spatial and functional heterogeneity of cancer-associated fibroblasts at the tumor center and invasive tumor front of oral squamous cell carcinoma with distinct worst patterns of invasion","description":"The worst pattern of invasion (WPOI) is an established prognostic feature in oral squamous cell carcinoma (OSCC), but the spatial contribution of cancer-associated fibroblasts (CAFs) to highly invasive WPOI4-5 tumors remains unclear. We performed bulk RNA sequencing of paired CAFs isolated from the tumor center and invasive tumor front of two WPOI1-3 and two WPOI4-5 OSCC tumors. This dataset supports paired analyses of regional expression differences and the WPOI-by-region interaction.","dates":{"publication":"2026/10/04"},"accession":"GSE349044","cross_references":{"GSM":["GSM10086194","GSM10086192","GSM10086193","GSM10086190","GSM10086191","GSM10086189","GSM10086187","GSM10086188"],"GPL":["29480"],"GSE":["349044"],"taxon":["Homo sapiens"]}}