{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE349nnn/GSE349121/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE349121"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptome profiling of synovial fibroblasts with ACOX1 overexpression","description":"This RNA-seq dataset was generated to investigate the transcriptional changes induced by ACOX1 overexpression in synovial fibroblasts. Synovial fibroblasts were divided into two experimental groups: a control group and an ACOX1-overexpression group. Each group consisted of six biological replicates. Total RNA was extracted from the cells and subjected to transcriptome sequencing. The resulting RNA-seq data were used to characterize ACOX1-associated transcriptional changes, with particular emphasis on inflammatory, metabolic, and extracellular-matrix-related pathways. These data provide transcriptomic evidence for investigating the role of ACOX1 in regulating the functional phenotype of synovial fibroblasts.","dates":{"publication":"2026/10/05"},"accession":"GSE349121","cross_references":{"GSM":["GSM10087339","GSM10087337","GSM10087348","GSM10087338","GSM10087346","GSM10087347","GSM10087344","GSM10087345","GSM10087342","GSM10087343","GSM10087340","GSM10087341"],"GPL":["28330"],"GSE":["349121"],"taxon":["Mus musculus"]}}