{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE349nnn/GSE349252/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE349252"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Functional genetic screening identifies ITGA3 as a regulator of pancreatic ductal adenocarcinoma growth and organoid architecture","description":"Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, with limited therapeutic options. In this study, we performed a targeted CRISPR screen and identified integrin a3 (ITGA3) as a dependency. ITGA3 knockdown resulted in reduced organoid cell viability, loss of luminal structure, and decreased invasion in collagen I. Transcriptomic analysis revealed that ITGA3 knockdown resulted in upregulation of cilia-related pathways, a finding not previously reported. ITGA3 knockdown also reduced tumor growth in vivo. This study expands on the role of ITGA3 in promoting aggressive cancer phenotypes and provides a novel link to cilia-related transcriptional programs.","dates":{"publication":"2026/10/01"},"accession":"GSE349252","cross_references":{"GSM":["GSM10090139","GSM10090132","GSM10090176","GSM10090154","GSM10090153","GSM10090175","GSM10090134","GSM10090156","GSM10090155","GSM10090133","GSM10090158","GSM10090136","GSM10090135","GSM10090157","GSM10090138","GSM10090137","GSM10090159","GSM10090170","GSM10090150","GSM10090172","GSM10090171","GSM10090152","GSM10090174","GSM10090173","GSM10090151","GSM10090143","GSM10090165","GSM10090164","GSM10090142","GSM10090167","GSM10090145","GSM10090144","GSM10090166","GSM10090147","GSM10090169","GSM10090146","GSM10090168","GSM10090149","GSM10090148","GSM10090161","GSM10090160","GSM10090141","GSM10090163","GSM10090140","GSM10090162"],"GPL":["30173"],"GSE":["349252"],"taxon":["Homo sapiens"]}}