GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE349nnn/GSE349252/primary200OKTranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE349252GEOGSEfalseFunctional genetic screening identifies ITGA3 as a regulator of pancreatic ductal adenocarcinoma growth and organoid architecturePancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, with limited therapeutic options. In this study, we performed a targeted CRISPR screen and identified integrin a3 (ITGA3) as a dependency. ITGA3 knockdown resulted in reduced organoid cell viability, loss of luminal structure, and decreased invasion in collagen I. Transcriptomic analysis revealed that ITGA3 knockdown resulted in upregulation of cilia-related pathways, a finding not previously reported. ITGA3 knockdown also reduced tumor growth in vivo. This study expands on the role of ITGA3 in promoting aggressive cancer phenotypes and provides a novel link to cilia-related transcriptional programs.2026/10/01GSE349252GSM10090139GSM10090132GSM10090176GSM10090154GSM10090153GSM10090175GSM10090134GSM10090156GSM10090155GSM10090133GSM10090158GSM10090136GSM10090135GSM10090157GSM10090138GSM10090137GSM10090159GSM10090170GSM10090150GSM10090172GSM10090171GSM10090152GSM10090174GSM10090173GSM10090151GSM10090143GSM10090165GSM10090164GSM10090142GSM10090167GSM10090145GSM10090144GSM10090166GSM10090147GSM10090169GSM10090146GSM10090168GSM10090149GSM10090148GSM10090161GSM10090160GSM10090141GSM10090163GSM10090140GSM1009016230173349252Homo sapiens