{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE38920"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Role of Ikaros in Mature IgM+ B-cells: Studies of IkZnF1-/- and IkZnF4-/- mutant mice [RNA-seq]","description":"Ikaros is a zinc finger (ZnF) transcription factor critical for B-cell development. The C2H2 zinc finger is the most prevalent DNA-binding motif in the mammalian proteome, with DNA-binding domains usually containing more tandem fingers than are needed for stable sequence-specific DNA recognition. To examine the reason for the frequent presence of multiple zinc fingers, we recently generated mice lacking finger 1 or finger 4 of the 4-finger DNA-binding domain of Ikaros. Each mutant strain exhibited a specific subset of the phenotypes observed with Ikaros null mice, and revealed that different subsets of fingers within multi-finger transcription factors can regulate distinct target genes and biological functions. We here study the effect of these mutants on mature B-cells with transcriptome profiling of sorted IgM+ B-cells from BM of wt and the two ZnF mutants (RNA-Seq).","dates":{"publication":"2026/05/30"},"accession":"GSE38920","cross_references":{"GSM":["GSM952083","GSM952084","GSM952087","GSM952088","GSM952085","GSM952086"],"GPL":["13112"],"SRA":["SRP013915"],"GSE":["38920"],"taxon":["Mus musculus"]}}