GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE38nnn/GSE38920/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE38920GEOGSEfalseRole of Ikaros in Mature IgM+ B-cells: Studies of IkZnF1-/- and IkZnF4-/- mutant mice [RNA-seq]Ikaros is a zinc finger (ZnF) transcription factor critical for B-cell development. The C2H2 zinc finger is the most prevalent DNA-binding motif in the mammalian proteome, with DNA-binding domains usually containing more tandem fingers than are needed for stable sequence-specific DNA recognition. To examine the reason for the frequent presence of multiple zinc fingers, we recently generated mice lacking finger 1 or finger 4 of the 4-finger DNA-binding domain of Ikaros. Each mutant strain exhibited a specific subset of the phenotypes observed with Ikaros null mice, and revealed that different subsets of fingers within multi-finger transcription factors can regulate distinct target genes and biological functions. We here study the effect of these mutants on mature B-cells with transcriptome profiling of sorted IgM+ B-cells from BM of wt and the two ZnF mutants (RNA-Seq).2026/05/30GSE38920GSM952083GSM952084GSM952087GSM952088GSM952085GSM95208613112SRP01391538920Mus musculus