{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE39nnn/GSE39069/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE39069"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Ikaros affects multiple lineages in hematopoietic development [RNA-Seq]","description":"Ikaros is a zinc finger transcription factor critical for proper hematopoietic development and tumor suppression in the lymphoid lineage. Here, we use the newly generated Ik-ZnF1-/- and Ik-ZnF4-/- mutant mice to study hematopoietic development in the BM. As an initial approach to study early hematopoietic development as well as non-lymphoid lineages, RNA-Seq was performed on \"Hardy Fraction A\" cells, without lineage depletion (B220+IgM-CD43+CD24-BP-1-), of wt and Ik-ZnF1-/- mice (two biological replicates of each). Ik-ZnF4-/- mice have extremely few cells in the \"Hardy fraction A\" gate, and only one RNA-Seq experiment was performed on this cell population, with strongly reduced reads/genome coverage.","dates":{"publication":"2026/05/30"},"accession":"GSE39069","cross_references":{"GSM":["GSM955180","GSM955181","GSM955177","GSM955178","GSM955179"],"GPL":["13112"],"SRA":["SRP013993"],"GSE":["39069"],"taxon":["Mus musculus"]}}