{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE40nnn/GSE40393/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by array"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE40393"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Gene x environment effect of serotonin transporter genotype and acute stressor on amygdala gene expression","description":"The amygdala is a prominent region of the brain processing stress-related emotion and vigilance. Additionally it is known that the serotonergic system is strongly involved in stress response and adaptation. The serotonin transporter (5-HTT) as key regulator of serotonergic activity in the brain is associated with stress-related neuropsychiatric disorders as well as heightened trait anxiety/dysphoria and exaggerated response to fear and environmental stress in humans. Also 5-HTT knockout mice display increased anxiety- and depression-related behaviors, altered stress reactivity and stress-coping abilities, gene expression differences and altered dendritic morphology. We measured immediate reactions to an acute stressor in 5-HTT knockout mice vs. wildtypes using microarrays for genome wide gene expression profiling in the amygdala and identified different functional clusters dependent on condition and genotype.","dates":{"publication":"2013/03/13"},"accession":"GSE40393","cross_references":{"GSM":["GSM992727","GSM992716","GSM992715","GSM992726","GSM992725","GSM992714","GSM992724","GSM992713","GSM992719","GSM992718","GSM992729","GSM992728","GSM992717","GSM992730","GSM992712","GSM992723","GSM992722","GSM992711","GSM992721","GSM992720"],"GPL":["6246"],"GSE":["40393"],"taxon":["Mus musculus"],"PMID":["[23536833]"]}}