GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE61nnn/GSE61313/primaryOK2000000GenomicsMus musculus Rattus norvegicus Homo sapiensNon-coding RNA profiling by arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE61313GEOGSE0falsemicroRNA-7 modulates Rb1 and c-Myc expression in myeloid leukemias harboring c-Kit mutationsThe receptor tyrosine kinase, c-kit, plays a pivotal role in hematopoiesis and self-renewal. Aberrant activation of c-kit can be induced by genetic alterations and is thought to confer therapeutic resistance in leukemia. Significantly, the c-kit D816V mutation is a well-known indicator of poor prognosis in acute myeloid leukemias harboring t(8;21) chromosomal translocations; however, the mechanism by which this mutation promotes therapeutic resistance is still unclear. Our study identified that miR-7 directly targets Retinoblastoma-like Protein 1 (Rb1) and is regulated by the MEK pathway. In addition, we also found that c-Myc is upregulated by the D816V mutation, and is indirectly downregulated by miR-7.2014/09/11GSE61313GSM1501967GSM15019661918261313Mus musculus Rattus norvegicus Homo sapiens