GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE64nnn/GSE64760/primary200OKTranscriptomicsMus musculusExpression profiling by arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE64760GEOGSEfalseGene expression in liver tissues derived from wild-type and Siglec-E-deficient mice at 55 weeks of ageWe show that mice lacking Siglec-E, the main member of the CD33rSiglec family, exhibit reduced survival. Removal of Siglec-E causes the development of exaggerated signs of aging at the molecular, structural, and cognitive level. We found that accelerated aging was related both to an unbalanced ROS metabolism, and to a secondary impairment in detoxification of reactive molecules, ultimately leading to increased damage to cellular DNA, proteins and lipids. Taken together, our data suggest that CD33rSiglecs co-evolved in mammals to achieve a better management of oxidative stress during inflammation, which in turn reduces molecular damage and extends lifespan.2016/01/15GSE64760GSM1579388GSM1579389GSM1579384GSM1579385GSM1579386GSM1579387688564760Mus musculus[25846707]