GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE69nnn/GSE69462/primaryOK2000000GenomicsHomo sapiensExpression profiling by arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE69462GEOGSE0falseThe phosphorylated prodrug FTY720 is a histone deacetylase Q15 inhibitor that reactivates ERĪ± expression and enhances hormonal therapy for breast cancerNuclear FTY720-P is a potent inhibitor of class I histone deacetylases (HDACs) that enhances histone acetylations and regulates expression of a restricted set of genes independently of its known effects on canonical signaling through sphingosine-1-phosphate (S1P) receptors. We found that FTY720 is phosphorylated in Era-negative breast cancer cells by nuclear sphingosine kinase 2 and accumulates these cells.2015/06/03GSE69462GSM1701525GSM1701514GSM1701515GSM1701526GSM1701516GSM1701527GSM1701528GSM1701517GSM1701518GSM1701519GSM1701520GSM1701521GSM1701522GSM1701523GSM170152457169462Homo sapiens[26053034]