GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE81nnn/GSE81245/primaryOK2000000GenomicsMus musculusExpression profiling by arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE81245GEOGSE0falseGene expression profiling of LMC and MMC motor neurons in SMA miceSpinal muscular atrophy (SMA) is a neurodegenerative disease which exhibits selective motor neuron death caused by a ubiquitous deficiency of the survival motor neuron (SMN) protein. It remains unclear how the ubiquitous reduction of SMN lead to death in selective motor neuron pools. Medial motor neuron columns (MMC) are vulnerable, whereas lateral motor columns (LMC) are resistant to motor neuron death in SMA. Here we performed microarray and pathway analysis comparing cholera toxin subunit B (CTb) labeled vulnerable MMC and resistant LMC of pre-symptomatic SMA with corresponding motor neuron columns of control mice to identify pathways involved in selective motor neuron death in SMA. WT is FVB. SMN is Delta7 (SMNĪ7;SMN2;Smn-) on a FVB background.2017/12/12GSE81245GSM2849872GSM2849861GSM2849860GSM2849871GSM2849870GSM2849880GSM2849869GSM2849858GSM2849857GSM2849879GSM2849868GSM2849878GSM2849867GSM2849866GSM2849877GSM2849876GSM2849865GSM2849864GSM2849875GSM2849863GSM2849874GSM2849873GSM2849862GSM2849859688781245Mus musculus[29281826]