GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE87nnn/GSE87448/primaryOK2000000GenomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE87448GEOGSE0falseActivation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancerChronic activation of Notch1 synergizes with multiple oncogenic pathways altered in early prostate cancer to promote the development of prostate adenocarcinoma. Expression profiling revealed that these tumors display features of epithelial-to-mesenchymal transition, a cellular state associated with increased tumor aggressiveness.Tumors driven by Notch1 intracellular domain in combination with multiple pathways altered in prostate cancer are metastatic and resistant to androgen deprivation.2016/12/07GSE87448GSM2331483GSM2331482GSM2331489GSM2331488GSM2331485GSM2331484GSM2331487GSM233148613112SRP09057287448Mus musculus[27694579]