GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE89nnn/GSE89660/primaryOK2000000GenomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE89660GEOGSE0falseComparison of gene expression patterns of two SCLC genetically-engineered mouse models; Rb1 floxed, Trp53 floxed, LSL-Myc T58A-IRES-Luc vs. Rb1 floxed, Trp53 floxed, Rbl2 (p130) floxedMyc expression cooperates with Rb1 and Trp53 loss in mouse lungs to generate rapid, aggressive, highly metastatic and neuroendocrine-low tumors that are similar to human variant subset of SCLC with high NEUROD1 expression. Targeted drug screening reveals that mouse and human MYC-driven SCLC are vulnerable to Aurora kinase inhibition in combination with chemotherapy in vivo.2017/01/12GSE89660GSM2386314GSM2386315GSM2386323GSM2386312GSM2386313GSM2386324GSM2386321GSM2386322GSM2386311GSM2386320GSM2386318GSM2386319GSM2386316GSM238631717021SRP09290689660Mus musculus[28089889]