GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE9nnn/GSE9189/primaryOK2000000GenomicsMus musculusExpression profiling by arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE9189GEOGSE0falseDifferentially regulated genes in normal LT-HSC vs ST-HSCSelf-renewal is a defining characteristic of stem cells, however the molecular pathways underlying its regulation are poorly understood. Here we demonstrate that conditional inactivation of the Pbx1 proto-oncogene in the hematopoietic compartment results in a progressive loss of long-term hematopoietic stem cells (LT-HSCs) that is associated with concomitant reduction in their quiescence, leading to a defect in the maintenance of self-renewal as assessed by serial transplantation. Transcriptional profiling revealed that multiple stem cell maintenance factors are perturbed in Pbx1-deficient LT-HSCs, which prematurely express a large subset of genes, including cell cycle regulators, normally expressed in non-self-renewing multipotent progenitors. Keywords: cell type comparison2008/05/07GSE9189GSM232046GSM232047GSM232051GSM232052GSM23205312619189Mus musculus[18462698]