GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE95nnn/GSE95755/primaryOK2000000GenomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE95755GEOGSE0falseMulticellular Transcriptional Analysis of Mammalian Heart RegenerationThe inability of the adult mammalian heart to regenerate following injury represents a major barrier in cardiovascular medicine. In contrast, the neonatal mammalian heart retains a transient capacity for regeneration, which is lost shortly after birth. Defining the molecular mechanisms that govern regenerative capacity in the neonatal period remains a central goal in cardiac biology. Here, we construct a transcriptional atlas of multiple cardiac cell populations, which enables comparative analyses of the regenerative (neonatal) versus non-regenerative (adult) state for the first time. This work provides a comprehensive transcriptional resource of multiple cardiac cell populations during cardiac development, repair and regeneration. Our findings define a transcriptional program underpinning the neonatal regenerative state and identifies an epigenetic barrier to re-induction of the regenerative program in adult cardiomyocytes.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 musculus[28733351]