GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE97nnn/GSE97109/primaryOK2000000GenomicsMus musculusMethylation profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE97109GEOGSE0falseMaternal obesity induced mouse embryonic defects derive from Stella insufficiency in oocytesIn order to obtain genome-wide profiles, base-resolution methylomes of zygotes were generated using the bisulfite sequencing (BS-seq) method for small samples. We find that global loss of DNA methylation during zygotic development in HFD mice. A total of 412 DMRs were identified, of which 294 were hypomethylated (hypo-DMRs; 71.4%) and 118 were hypermethylated (hyper-DMRs; 28.6%) (Fig. 6A and 6B), showing a predominance of hypo-DMRs. Furthermore, we show that hyper-DMRs are significantly depleted from CGI, but enriched in short interspersed elements (SINEs) and non-CGI regions. Strikingly, hypo-DMRs are specifically depleted from SINEs, with a concurrent enrichment in DNA transposons.2017/03/28GSE97109GSM2551847GSM2551846GSM2551849GSM255184813112SRP10256197109Mus musculus[29459681]