GPMDB00193OtherRosenow A, et al.InstrumentNot AvailableNot availableHuman, Human_adenovirus_54, Human_adenovirus_a, Human_adenovirus_b, Human_adenovirus_c, Human_adenovirus_d, Human_adenovirus_e, Human_adenovirus_f, Human_adenovirus_g, Human_astrovirus, Human_bocavirus, Human_bocavirus_2, Human_bocavirus_3, Human_bocavirus_4, Human_coronavirus_229e, Human_coronavirus_hku1, Human_coronavirus_nl63, Human_coronavirus_oc43, Human_cosavirus_a, Human_cosavirus_b, Human_cosavirus_d, Human_cosavirus_e, Human_enteric_coronavirus_4408, Human_enterovirus_100, Human_enterovirus_a, Human_enterovirus_b, Human_enterovirus_c, Human_enterovirus_d, Human_erythrovirus_v9, Human_herpesvirus_1, Human_herpesvirus_2, Human_herpesvirus_3, Human_herpesvirus_4_type_1, Human_herpesvirus_4_type_2, Human_herpesvirus_5, Human_herpesvirus_6a, Human_herpesvirus_6b, Human_herpesvirus_7, Human_herpesvirus_8_type_p, Human_immunodeficiency_virus_1, Human_immunodeficiency_virus_2, Human_metapneumovirus, Human_papillomavirus_fa75_ki88_03, Human_papillomavirus_rtrx7, Human_papillomavirus_type_10, Human_papillomavirus_type_100, Human_papillomavirus_type_101, Human_papillomavirus_type_103, Human_papillomavirus_type_104, Human_papillomavirus_type_105, Human_papillomavirus_type_108, Human_papillomavirus_type_109, Human_papillomavirus_type_112, Human_papillomavirus_type_113, Human_papillomavirus_type_16, Human_papillomavirus_type_24, Human_papillomavirus_type_26, Human_papillomavirus_type_32, Human_papillomavirus_type_34, Human_papillomavirus_type_4, Human_papillomavirus_type_41, Human_papillomavirus_type_48, Human_papillomavirus_type_49, Human_papillomavirus_type_5, Human_papillomavirus_type_50, Human_papillomavirus_type_53, Human_papillomavirus_type_60, Human_papillomavirus_type_63, Human_papillomavirus_type_6b, Human_papillomavirus_type_7, Human_papillomavirus_type_71, Human_papillomavirus_type_88, Human_papillomavirus_type_9, Human_papillomavirus_type_92, Human_papillomavirus_type_96, Human_papillomavirus_type_98, Human_papillomavirus_type_99, Human_papillomavirus___1, Human_papillomavirus___18, Human_papillomavirus___2, Human_papillomavirus___54, Human_papillomavirus___61, Human_papillomavirus___cand90, Human_parainfluenza_virus_1, Human_parainfluenza_virus_2, Human_parainfluenza_virus_3, Human_parechovirus, Human_parvovirus_4, Human_parvovirus_b19, Human_picobirnavirus, Human_respiratory_syncytial_virus, Human_rhinovirus_a, Human_rhinovirus_b, Human_rhinovirus_c, Human_tmev_like_cardiovirus, Human_t_lymphotropic_virus_1, Human_t_lymphotropic_virus_2, Human_t_lymphotropic_virus_4Not availablea.rosenow@maastrichtuniversity.nlhttp://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004360http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004361http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004353http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004397http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004430http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004354http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004398http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004351http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004395http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004352http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004396http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004357http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004358http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004355http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004399http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004356http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004359http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004371http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004372http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004370http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004364http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004365http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004362http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004363http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004401http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004368http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004402http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004369http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004366http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004400http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004367http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004405http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004406http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004403http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004404http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004409http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004407http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004408http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004382http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004383http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004380http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004381http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004375http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004376http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004373http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004374http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004412http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004379http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004413http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004377http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004410http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004411http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004416http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004417http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004414http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004415http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004418http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004419http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004390http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004393http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004394http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004391http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004392http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004386http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004420http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004387http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004384http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004385http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004423http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004424http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004388http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004421http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004422http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004389http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004427http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004428http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004425http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004426http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210004429Department of Human Biology, Maastricht UniversityCL:0000136 fat cellGPMDB5-stilbenetriol, human being, exocrine gland fluid, exocrine gland fluid or secretion, 5-[2-(4-hydroxyphenyl)ethenyl]benzene-1, InChI=1/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9, Homo sapiense, external secretion., exocrine gland fluid/secretion, 15-17H, Homo spaiens, adipose cell, Homo sapien, Homo sapian, trans-resveratrol-3-O-sulfate, Homo sapians, 3, secretion, 5, cis-resveratrol, Homo sapeins, adipocyte, SRT-501, Homo sapients, 4'-trihydroxystilbene, trans-resveratrol, 3-diol, SRT501, C14H12O3, Humo sapiens, man, Homo sapines, human, fat cell, 5-Trihydroxystilbene, resveratrol-3-sulfate, secreted substance, Homo spiens, "human" EXACT genbank_common_name [], Homo sapience, bodily secretion, SRT 501, Homo sampiens, InChIKey=LUKBXSAWLPMMSZ-UHFFFAOYAJ, [H]C(=C([H])c1cc(O)cc(O)c1)c1ccc(O)cc1, 4', lipocyte, Home sapiens, exocrine gland secretionprojections, concomitant conditions, APO-E, Soluble, Adult-Onset Diabetes Mellitus, Dysplasia gigantism syndrome, Other diseases of pericardium (disorder), nucleocytoplasm, Raw, Cardiovascular disease, 5-[2-(4-hydroxyphenyl)ethenyl]benzene-1, Other pericardial disease NOS (disorder), Cardiovascular disorder, PAPILLARY MUSCLE DIS NEC, Type 2 Diabetes Mellitus, Homo sapiense, electronic data file, Downregulation, Stromal cell-derived factor 3, unspecified, Homo sapien, Disease of cardiovascular system (disorder), Other heart disease NOS, Non-Insulin Dependent Diabetes Mellitus, 1, 2, 3, 5, ACDC, 3-Propanetriol, treatment, Cardiovascular Diseases, Homo sapients, lipid breakdown, associated disease, [X]Other forms of heart disease (disorder), Other ill-defined heart disease (disorder), composition, proteins, 30 kDa adipocyte complement-related protein, Cardiovascular Disorder, elevated, circulatory system disease, endocrine, NIDDM, Ketosis-Resistant Diabetes Mellitus, Disorder of cardiovascular system, decreased, SGB, AD2, sequelae, apM-1 Protein, PAI, Circulatory system disease NOS (disorder), Regular, anatomical protrusion, Endothelial plasminogen activator inhibitor, concomitant disease, Bulldog syndrome, Up-Regulation (Physiology), PAI-1, disease of subdivision of hemolymphoid system, partial functionality, AI255918, Regular Insulin, exocrine gland fluid/secretion, multicellular organismal lipid catabolic process, Adult-Onset Diabetes, Homo sapian, Simpson Dysplasia Syndrome, Obesity [Ambiguous], shelf, computer data file, OBESITY, secretion, Ketosis Resistant, Soluble Insulin, Maturity-Onset Diabetes Mellitus, CARDIOVASC DIS, 4'-trihydroxystilbene, SDF-3, Upregulation, content, expanded, Type II Diabetes, Disorder of the circulatory system, Adiposity, OBESITY NOS, [X]Other ill-defined heart diseases (disorder), projection, ridge, human, fat cell, Matrix Proteins, Fat Cell, ILL-DEFINED HRT DIS NEC, Cells, adipocyte complement-related 30 kDa protein, Disease affecting entire cardiovascular system, Slow-Onset, exocrine gland secretion, big, T2DM - Type 2 Diabetes mellitus, PLANH1, GLYCEROL, Cardiovascular system disease, 5-stilbenetriol, coexistent disease, X-linked, lamellae, SDYS, X-linked dysplasia gigantism syndrome, PEDF, impaired, Other diseases of pericardium, Other disorders of papillary muscle, process of organ, unspecified (disorder), lamella, Disorder of cardiovascular system (disorder), large, 15-17H, Homo spaiens, OCI-5, APOEA, ADIPOQ, Certain sequelae of myocardial infarction, C1q and collagen domain-containing protein, coexistent conditions, Insulin, Gene Products, MXR7, Other ill-defined heart disease NOS (disorder), Unspecified circulatory system disorder, Chain, DISEASES OF THE CIRCULATORY SYSTEM, trans-resveratrol, Receptor Up-Regulation, SRT501, dysfunction, Glycerin, Other forms of heart disease, man, Other specified pericardial disease NOS, AI195227, OI12, cardiovascular disease, Pedfl, bodily secretion, Simpson-Golabi-Behmel syndrome type 1, Diabetes Mellitus, Extracellular, Lipocyte, Pedf, lipocyte, laminae, high elevation, adipocytus unigutturalis, OTHER SEQUELAE OF MI NEC, SGBS, Adipose Most Abundant Gene Transcript 1, lipid catabolism, anatomical process, Proteins, MODY, function, Disease affecting entire cardiovascular system (disorder), compositionality, Cell, OI6, Down Regulation, polypeptide, adipose cell, Down-Regulation, apM-1, Down-Regulation (Physiology), chemical analysis, Simpson dysmorphia syndrome, Insulin A Chain, Maturity-Onset, Slow-Onset Diabetes Mellitus, regulation of apoptosis, Sodium, Novolin, Homo sapeins, adipocyte, Other ill-defined heart disease NOS, Obesity (disorder), organ process, Other specified diseases of pericardium, Cardiovascular, Col4a-1, underdeveloped, [X]Other ill-defined heart diseases, increased number, Obesity NOS, Specificity, Humo sapiens, [X]Other forms of heart disease, Other sequelae of myocardial infarction, CVS disease, Gene Proteins, processes, having decreased function, Extracellular Matrix, Homo spiens, APM1, structure, InChIKey=LUKBXSAWLPMMSZ-UHFFFAOYAJ, Adipocyte Complement Related Protein 30 kDa, Receptor, Stable Diabetes Mellitus, lipolysis, Bru, Insulin B Chain, determination, InChI=1/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9, Other heart disease NOS (disorder), composed of, diabetes mellitus type 2, [X]Other specified diseases of pericardium (disorder), Cardiovascular Disease (CVD), Adiposis, Caspin, dysfunctional, Obese, Glycerol, Homo sapians, CVD, multicellular organism lipid catabolic process, DGSX, Slow Onset, present in fewer numbers in organism, Svc, increased, hypoplasia, Other diseases of endocardium, adipose most abundant gene transcript 1 protein, Homo sapience, Lipocytes, papilla, disease management, 4', associated, Non Insulin Dependent, Home sapiens, gelatin-binding protein, external secretion, lamina, Serpin E1, flanges, Disorder of circulatory system, Sdf3, PAI1, Fat Cells, Adult-Onset, LDLCQ5, Receptor Down-Regulation, Ill-defined descriptions and complications of heart disease, glycerol, Obese (finding), Diseases, Adipocytokines, NOS, Other pericardial disease NOS, internal to cell, lipid degradation, CIRCULATORY DISEASE NOS, Adipocyte, sequels, C14H12O3, Mental Retardation-Overgrowth Syndrome, shelves, Type 2, lacks function of type, Homo sapines, low functionality, Type 1, ACRP30 Protein, Non-Insulin Dependent Diabetes, enlarged, Specificity and Sensitivity, spine, [H]C(=C([H])c1cc(O)cc(O)c1)c1ccc(O)cc1, Serpin F1, Fat, ACRP30, accessory, Cardiovascular Disorders, ASCVD, human being, exocrine gland fluid, C1q and Collagen Domain Containing Protein, exocrine gland fluid or secretion, Noninsulin Dependent, Other heart disease (disorder), Gene, Insulin B, DIABETES MELLITUS TYPE 02, supernumerary, protrusion, Obesity, Lipolyses, [X]Cardiovascular disease, Glycerine, reduced, Simpson-Golabi-Behmel Syndrome, Adipokine, Golabi-Rosen syndrome, subnumerary, trans-resveratrol-3-O-sulfate, Non-Insulin-Dependent, non-insulin-dependent diabetes mellitus, Del(8)44H, tiny, sensitivity, protoplasm, study, LPG, hormones, Other diseases of endocardium (disorder), [X]Other specified diseases of pericardium, protoplast, propane-1, Up Regulation, Other heart disease, Overweight and obesity, Maturity Onset Diabetes Mellitus, ridges, decreased number, resveratrol-3-sulfate, secreted substance, Iletin, Simpson Syndrome, Stable, SRT 501, Homo sampiens, great, EPC-1, unilocular adipose tissue, Planh1, Disease of cardiovascular system, Sensitivity, Ketosis-Resistant, Diabetes, Circulatory system disease NOS, textus adiposus albus, Dmrs91, Adult Onset, small, Gene., Disease, Adipocyte Complement-Related Protein 30-kDa, Other ill-defined heart diseases, not elsewhere classified, 3-triol, apoptosis regulator activity, Other ill-defined heart disease, obesity, SGBS1, Sodium Insulin, Protein, apM 1 Protein, Type 2 Diabetes Mellitus Non-Insulin Dependent, cis-resveratrol, Other forms of heart disease (disorder), SRT-501, adipocyte-specific protein AdipoQ, PERICARDIAL DISEASE NEC, flange, 3-Trihydroxypropane, Type 2 Diabetes, 3-diol, Cell proliferation-inducing gene 35 protein, INS, associated conditions, GBP28, 5-Trihydroxystilbene, GTR2-2, Cardiovascular Disease, Protein Gene Products, present in greater numbers in organism, process, Other specified pericardial disease NOS (disorder), "human" EXACT genbank_common_name [], white fat, processus, assay, Type II, Maturity Onset190http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM112100043603dbgap_ncbi~0patentfamilies~0rfam~0merops~0complex-portal~0uniprot~0wormbaseparasite~0embl-covid19~0reactome~0emdb~0wgs_masters~0ebiweb_resources~0opentargets_genetics~0biomodels_all~0ipd-mhc~0ebiweb_teams~0taxonomy~0genome_assembly~0sc-experiments~0ebiweb_people~0enzymeportal_enzymes~0ipd-nhkir~0cellosaurus~0pdbe~0chebi~0patentproteins~0interpro7~0uniref~0chembl~0pdbekb~0gpcrdb~0hgnc~0sc-genes~0intact~0rhea~0ebiweb_training~0alphafold~0imgt-hla~0patentnucleotides~0ensemblroot~0eva_studies~0non-coding~0europepmc~0identifiers_registry~0pdbechem~0hpa-covid19~0eva-variants-covid19~0biosamples~0gwas_catalog~0biotools~0tls_masters~0mesh~0coding~0sra~0opentargets~0efo~0embl-pathogen~0project~0pride~1human_diseases~0geo_datasets~0embl~0treefam~0uniparc~0ols~0dgva~0intenz~0go~0tsa_masters~0biosamples-covid19~0ebiweb_corporate~0omim~0lrg~0earlycause-molecular-sequences~0ipd-kir~0empiar~0rnacentral~0orcid_data_claims~0gpmdb~1lineage-covid19~0metagenomics~0pfam~0pride archive~1varsite~00Resource Reanalysis0.00.00.0058605798889574340.01.0falseResveratrol-induced changes of the human adipocyte secretion profilePRIDE ID: 27081, PXD ID: PXD000012. Original data file: peptide11871.RAW. From PRIDE: {{i}} Enlarged white adipose tissue (WAT) is a feature of obesity and leads to changes in its paracrine and endocrine function. Dysfunction of WAT cells is associated with obesity associated disorders like type 2 diabetes and cardiovascular diseases. Resveratrol (RSV) a natural polyphenolic compound mimics beneficial effects of calorie restriction. As such, RSV seems a promising therapeutic target for obesity-associated disorders. The effect of RSV on the human adipokine profile is still elusive. Therefore, a proteomic study together with bioinformatical analysis was performed to investigate the effect of RSV on the secretion profile of mature human Simpson-Golabi-Behmel syndrome (SGBS) adipocytes. RSV incubation resulted in elevated basal glycerol release and reduced intracellular TG content. This increased intracellular lipolysis was accompanied by profound changes in the adipocyte secretion profile. Extracellular matrix proteins were down-regulated while processing proteins were mostly up-regulated after RSV treatment. Interestingly, RSV induced secretion of proteins protective against cellular stress and proteins involved in the regulation of apoptosis. Furthermore, we found a RSV-induced up-regulation of adiponectin and ApoE accompanied by a down-regulation of PAI-1 and PEDF secretion which may improve anti-inflammatory processes and increased insulin sensitivity. These effects are beneficial to alleviate obesity-induced metabolic complications. In addition, two novel RSV-regulated adipocyte-secreted proteins were identified.{{/i}}2012-09-02GPM11210004360PXD000012PXD000012