{"database":"GPMDB","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":19,"searchCount":3},"additional":{"omics_type":["Other"],"submitter":["Wenger CD, et al."],"instrument_platform":["Instrument"],"disease":["Not Available"],"brenda_tissue":["Not available"],"species":["Yeast"],"submitter_mail":["wenger@gmail.com"],"publication":["23323968"],"submitter_affiliation":["Genome Center of Wisconsin, University of Wisconsin−Madison and Agilent Laboratories, Agilent Technologies"],"model":["http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210018158","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210018148","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210018159","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210018156","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210018157","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210018149","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210018161","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210018150","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210018151","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210018160","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210018154","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210018155","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210018152","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210018153"],"cell_type":["Not available"],"repository":["GPMDB"],"pubmed_abstract":["The acquisition of high-resolution tandem mass spectra (MS/MS) is becoming more prevalent in proteomics, but most researchers employ peptide identification algorithms that were designed prior to this development. Here, we demonstrate new software, Morpheus, designed specifically for high-mass accuracy data, based on a simple score that is little more than the number of matching products. For a diverse collection of data sets from a variety of organisms (E. coli, yeast, human) acquired on a variety of instruments (quadrupole-time-of-flight, ion trap-orbitrap, and quadrupole-orbitrap) in different laboratories, Morpheus gives more spectrum, peptide, and protein identifications at a 1% false discovery rate (FDR) than Mascot, Open Mass Spectrometry Search Algorithm (OMSSA), and Sequest. Additionally, Morpheus is 1.5 to 4.6 times faster, depending on the data set, than the next fastest algorithm, OMSSA. Morpheus was developed in C# .NET and is available free and open source under a permissive license."],"pubmed_title":["A proteomics search algorithm specifically designed for high-resolution tandem mass spectra."],"pubmed_authors":["Wenger Craig D CD,Coon Joshua J JJ,","Wenger Craig D CD, Coon Joshua J JJ"],"name_synonyms":["OCTD, ACMICD, FBN, MFS1, MASS, GPHYSD2, ECTOL1, WMS, Algorithm, WMS2, SGS, SSKS."],"description_synonyms":["human being, AU018859, Slf, CDM, Coronary Diseases, Somatomedin-C, baker's yeast, FPH2, Heart Diseases, Coronary, Homo sapiense, 3.-.-.-, Saccharomyces italicus, Homo spaiens, Homo sapien, TOF, IT, morpheus, Homo sapians, yeast, Heart Disease, Arterioscleroses, Caspase-activated nuclease, lager beer yeast, CORONARY ARTERY DIS, Coronary Heart, 5730477D02Rik, CPAN, Homo sapients, Coronary Arteriosclerosis, 4.1.1.6, NPIP, Coronary Atheroscleroses, Cpad, beta-Trypsin, somatomedin-C, Atheroscleroses, Coronary Artery Diseases, SF, Saccharomyes cerevisiae, Coronary Disease, CALD1, Kitl, Immune-responsive gene 1 protein, Saccharomyces uvarum var. melibiosus, man, Mast cell growth factor, DFF40, 2410008J01Rik, Candida robusta, Homo sapience, Saccharomyces capensis, IGF1, Homo sampiens, Mechano growth factor, Soluble KIT ligand, brewer's yeast, Sl, Home sapiens, CHD - Coronary heart disease, CHD, IGF-I, data, Disease, Coronary Heart Diseases, steel factor, NPIPA, Laboratory., CORONARY HEART DIS, hematopoietic growth factor KL, somatomedin, Caspase-activated DNase, CORONARY DIS, Saccaromyces cerevisiae, collisionally activated dissociation, sKITLG, CID, Coronary Artery, Sccharomyces cerevisiae, Experiment, CAD, Cad, Homo sapian, mechano growth factor, Diseases, Didff, DFF2, Coronary Arterioscleroses, Arteriosclerosis, Homo sapeins, 40kDa, Igf-1, Aconitate decarboxylase, Saccharomyces oviformis, Yeast, SHEP7, DNA fragmentation factor 40 kDa subunit, mast cell growth factor, Artery Diseases, Caspase-activated deoxyribonuclease, Stem cell factor, Coronary Atherosclerosis, Tripcellim, Humo sapiens, Atherosclerosis, AI323667, STAT5, beta Trypsin, Homo sapines, human, CHD (coronary heart disease), DFF-40, Trypure, stem cell factor, Homo spiens, KL-1, \"human\" EXACT genbank_common_name [], Artery Disease, Cis-aconitic acid decarboxylase, Coronary Artery Disease, MGF, c-Kit ligand, KITLG, SCF, Proteomes"],"pubmed_title_synonyms":["OCTD, ACMICD, FBN, MFS1, MASS, GPHYSD2, ECTOL1, WMS, Algorithm, WMS2, SGS, SSKS."],"pubmed_abstract_synonyms":["AW488255, negative regulation of adrenergic receptor signalling pathway, human being, single-organism developmental process, Laboratory, AW549739, number, D430049E23Rik, FBN, baker's yeast, Computer, Spectrum Analyses, Homo sapiense, Saccharomyces italicus, peptide, Homo spaiens, Homo sapien, TOF, Hek6, ECTOL1, IT, morpheus, Homo sapians, yeast, Mass, Cek6, Software Engineering, Analysis, WMS, Computer Program, Application, lager beer yeast, Mass Spectroscopy, ENSMUSG00000074119, C79691, Mass Spectrum Analysis, ERP, Erp, proportion, Elkh, Homo sapients, Identification, Analyses, Software Application, NPIP, EK6, Tyrosine-protein kinase receptor EPH-2, Computer Programs and Programming, Saccharomyes cerevisiae, proteins, number of, Sap-2, Saccharomyces uvarum var. melibiosus, man, Computer Software Application, OCTD, Lccp, mKIAA0989, 2.7.10.1, Candida robusta, Tools, Solute carrier family 6 member 2, Homo sapience, Saccharomyces capensis, Homo sampiens, Etrp, has or lacks parts of type, SLC6A5, NET1, NAT1, brewer's yeast, GPHYSD2, SIMPLE, Home sapiens, NET, Net, SGS, TP53I7, ratio, Applications Software, data, ELK, Elk, C130099E04Rik, Computer Software, NPIPA, Data Set, Neuronally-expressed EPH-related tyrosine kinase, free., EPH tyrosine kinase 2, SAP2, extra or missing physical or functional parts, 9330129L11, Spectrum Analysis, Saccaromyces cerevisiae, Software Tools, Tool, ACMICD, Programs, mereological quality, Spectroscopy, polypeptide, development, Sccharomyces cerevisiae, Program, Computer Applications, Software Tool, Norepinephrine transporter, Homo sapian, PIG7, Algorithm, Computer Applications Software, Computer Applications Softwares, EPH-like kinase 6, MFS1, Softwares, Homo sapeins, Software, Mass Spectrum Analyses, WMS2, Saccharomyces oviformis, Mass Spectrum, Yeast, Software Applications, Engineering, proportionality, Spectrometry, Humo sapiens, Identifications (Psychology), rate, MASCOT, MASS, hEK6, Homo sapines, human, Computer Programs, Applications, Homo spiens, \"human\" EXACT genbank_common_name [], Applications Softwares, false, EPHT2, SSKS, cardinality, regulation of adrenergic receptor signalling pathway, quotient, Computer Software Applications"],"view_count":["19"],"citation_count":["0"],"search_count":["3"],"full_dataset_link":["http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210018150"],"search_domains":["dbgap_ncbi~0","patentfamilies~0","rfam~0","merops~0","complex-portal~0","uniprot~0","wormbaseparasite~0","embl-covid19~0","reactome~0","emdb~0","wgs_masters~0","ebiweb_resources~0","opentargets_genetics~0","biomodels_all~0","ipd-mhc~0","ebiweb_teams~0","taxonomy~0","genome_assembly~0","sc-experiments~0","ebiweb_people~0","enzymeportal_enzymes~0","ipd-nhkir~0","cellosaurus~0","pdbe~0","chebi~0","patentproteins~0","interpro7~0","uniref~0","chembl~0","pdbekb~0","gpcrdb~0","hgnc~0","sc-genes~0","intact~0","rhea~0","ebiweb_training~0","alphafold~0","imgt-hla~0","patentnucleotides~0","ensemblroot~0","eva_studies~0","non-coding~0","europepmc~0","pubmed~1","identifiers_registry~0","pdbechem~0","hpa-covid19~0","eva-variants-covid19~0","biosamples~0","gwas_catalog~0","biotools~0","tls_masters~0","mesh~0","coding~0","sra~0","opentargets~0","efo~0","embl-pathogen~0","project~0","human_diseases~0","geo_datasets~0","embl~0","treefam~0","uniparc~0","ols~0","dgva~0","intenz~0","go~0","tsa_masters~0","biosamples-covid19~0","ebiweb_corporate~0","omim~0","lrg~0","earlycause-molecular-sequences~0","ipd-kir~0","empiar~0","rnacentral~0","orcid_data_claims~0","gpmdb~2","lineage-covid19~0","metagenomics~0","pfam~0","varsite~0"],"citation_count_scaled":["0.0"],"reanalysis_count_scaled":["0.0"],"view_count_scaled":["0.005860579888957434"],"download_count_scaled":["0.0"],"reanalysis_count":["0"],"normalized_connections":["1.0"],"additional_accession":[]},"is_claimable":false,"name":"A proteomics search algorithm specifically designed for high-resolution tandem mass spectra.","description":"Data from the authors [[www.chem.wisc.edu/~coon/Downloads/Morpheus web site]]. Experiment: yeast cad, file: 2010-12-05_Yeast_Trypsin_IT_CAD_Rep4.mgf. Published as part of J Proteome Res. 2013 Mar 1;12(3):1377-86 [[http://www.ncbi.nlm.nih.gov/pubmed/23323968 PubMed]]. From the Abstract: {{i}} ... For a diverse collection of data sets from a variety of organisms (E. coli, yeast, human) acquired on a variety of instruments (quadrupole-time-of-flight, ion trap-orbitrap, and quadrupole-orbitrap) in different laboratories ... {{/i}}","dates":{"submission":"2013-06-16"},"accession":"GPM11210018150","cross_references":{"pubmed":["23323968"]}}