{"database":"GPMDB","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":47,"searchCount":5},"additional":{"omics_type":["Other"],"submitter":["Kjellin H, et al."],"instrument_platform":["Instrument"],"disease":["Not Available"],"brenda_tissue":["Not available"],"species":["Homo_sapiens_viruses, Human"],"submitter_mail":["hanna.kjellin@ki.se"],"publication":["24498411"],"submitter_affiliation":["Department of Medicine, Karolinska Institutet"],"model":["http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210025579"],"cell_type":["Not available"],"repository":["GPMDB"],"pubmed_abstract":["We have compared the microsomal protein composition of eight malignant and six benign adrenocortical tumors with proteomic methods. IGF2 had increased level in the malignant tumors, confirming previous microarray studies on the same material. Aldolase A, a glycolytic enzyme, also showed increased levels in the malignant tissue compared to the benign. Additionally, several proteins belonging to complex I in the mitochondrial respiration chain showed decreased levels in the malignant tissue. Taken together, this may indicate a shift in energy metabolism where glycolysis may be favored over tight coupling of glycolysis and mitochondrial respiration, a phenomenon known as the Warburg effect. One of the complex I proteins that showed decreased levels in the malignant tissue was GRIM-19. This protein has been suggested as a tumor suppressive protein by being a negative regulator of STAT3. In summary, an analysis of the microsomal proteome in adrenocortical tumors identifies groups of proteins as well as specific proteins differentially expressed in the benign and malignant forms. These proteins shed light on the biology behind malignancy and could delineate future drug targets."],"pubmed_title":["Differentially expressed proteins in malignant and benign adrenocortical tumors."],"pubmed_authors":["Kjellin Hanna H,Johansson Henrik H,Höög Anders A,Lehtiö Janne J,Jakobsson Per-Johan PJ,Kjellman Magnus M,","Kjellin Hanna H, Johansson Henrik H, Höög Anders A, Lehtiö Janne J, Jakobsson Per-Johan PJ, Kjellman Magnus M"],"name_synonyms":["Protein Gene Products, Gene Proteins, polypeptide, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS), Protein, Neoplasms, Gene Products, Proteins, NEOPL., Gene, proteins, tumour, benign, Tumor, NEOPLASMS BENIGN, Neoplastic Growth, Neoplasia, tumours, Tumors"],"description_synonyms":["data, Chromosome region maintenance 1 protein homolog, Procedures, Neoplasms, Crm1, tumour, Methodological, procedures, benign, Tumor, Procedure, exp1, Methodological Study, tumours, NEOPL, Study, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS), Experiment, Methodological Studies, Method, CRM1, Studies, Exp1, techniques, methodology., emb, AA420417, NEOPLASMS BENIGN, Neoplastic Growth, Neoplasia, Tumors"],"pubmed_title_synonyms":["Protein Gene Products, Gene Proteins, polypeptide, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS), Protein, Neoplasms, Gene Products, Proteins, NEOPL., Gene, proteins, tumour, benign, Tumor, NEOPLASMS BENIGN, Neoplastic Growth, Neoplasia, tumours, Tumors"],"pubmed_abstract_synonyms":["Fructosemonophosphate Aldolase, Procedures, respiration, determination, Metabolisms, Neoplasms, Mpr, Gene, Bioenergetics, Embden-Meyerhof, Fructosediphosphate Aldolase, Visible Light, Tumor, Embden Meyerhof Parnas Pathway, supernumerary, Fructose 1, NEOPL, Fructosediphosphate, Fructose Biphosphate Aldolase, 6-Bisphosphate Aldolase, reduced, NADH-ubiquinone oxidoreductase B16.6 subunit, Complex I-B16.6, Method, subnumerary, Metabolism, IGFII, Studies, C11orf43, Gene Products, 1, Embden-Meyerhof Pathway, light, 6-Bisphosphate, Expenditure, drug., present in fewer numbers in organism, portion of tissue, increased, oxidative metabolic process, Grim19, Igf-II, NADH:plastoquinone reductase complex, HIES, Fructose 1-Phosphate, Tissue, 6-biphosphate D-glyceraldehyde-3-phosphate-lyase, somatomedin-A, Energy, Pathways, tumour, proteins, B16.6, procedures, benign, Visible, decreased number, Expenditures, multiplication-stimulating polypeptide, Aldolase B, Aldolase A, Fructose Bisphosphate Aldolase, Study, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS), Fructose 1-Phosphate Aldolase, CDA016, ch, drugs, decreased, NADH dehydrogenase complex (quinone), Methodological Studies, IGF2, M6pr, Complex I, medicine, Cell death regulatory protein GRIM-19, TR2, GRIM19, Neoplastic Growth, modifed Embden-Meyerhof pathway, Tumors, Cancer, ADMIO, Pathway, Gene associated with retinoic and IFN-induced mortality 19 protein, Radiation, Embden Meyerhof Pathway, Proteins, CGI-39, anaerobic glycolysis, GRIM-19, Light, Procedure, Embden-Meyerhof-Parnas, CD258, tumours, oxidative metabolism, polypeptide, Embden-Meyerhof-Parnas Pathway, Peg2, Aldolase C, 2700054G14Rik, LIGHT, NADH dehydrogenase complex (plastoquinone), Fructosemonophosphate, Protein, chemical analysis, tissue portion, Gene associated with retinoic and interferon-induced mortality 19 protein, Fructose Biphosphate, simple tissue, Fructose-Bisphosphate, techniques, Igf-2, regulator, plastid NADH dehydrogenase complex (plastoquinone), Breathing, D-Fructose-1, APRF, IGF-II, Energy Expenditure, Visible Radiations, Radiations, Visible Radiation, HVEML, increased number, Fructose 1 Phosphate Aldolase, CI-B16.6, Photoradiation, Energy Expenditures, Methodological, Cancers, Methodological Study, Embden-Meyerhof-Parnas pathway, RNIGF2, Aprf, Aldolase, Embden-Meyerhof pathway, Bioenergetic, LTg, AL033362, AW109958, Protein Gene Products, present in greater numbers in organism, Gene Proteins, breathing, Energy Metabolisms, glycolysis, 1110034C02Rik, Photoradiations, 6 Bisphosphate Aldolase, Fructose, AU022060, microarray, assay, Class II, PP9974, NADH dehydrogenase complex (ubiquinone), Embden-Meyerhof Pathways, Proteomes, NEOPLASMS BENIGN, Neoplasia, accessory, methodology"],"view_count":["47"],"citation_count":["0"],"search_count":["5"],"full_dataset_link":["http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210025579"],"search_domains":["dbgap_ncbi~0","patentfamilies~0","rfam~0","merops~0","complex-portal~0","uniprot~0","wormbaseparasite~0","embl-covid19~0","reactome~0","emdb~0","wgs_masters~0","ebiweb_resources~0","opentargets_genetics~0","biomodels_all~0","ipd-mhc~0","ebiweb_teams~0","taxonomy~0","genome_assembly~0","sc-experiments~0","ebiweb_people~0","enzymeportal_enzymes~0","ipd-nhkir~0","cellosaurus~0","pdbe~0","chebi~0","patentproteins~0","interpro7~0","uniref~0","chembl~0","pdbekb~0","gpcrdb~0","hgnc~0","sc-genes~0","intact~0","rhea~0","ebiweb_training~0","alphafold~0","imgt-hla~0","patentnucleotides~0","ensemblroot~0","eva_studies~0","non-coding~0","europepmc~0","pubmed~1","identifiers_registry~0","pdbechem~0","hpa-covid19~0","eva-variants-covid19~0","biosamples~0","gwas_catalog~0","biotools~0","tls_masters~0","mesh~0","coding~0","sra~0","opentargets~0","efo~0","embl-pathogen~0","project~0","pride~1","human_diseases~0","geo_datasets~0","embl~0","treefam~0","uniparc~0","ols~0","dgva~0","intenz~0","go~0","tsa_masters~0","biosamples-covid19~0","ebiweb_corporate~0","omim~0","lrg~0","earlycause-molecular-sequences~0","ipd-kir~0","empiar~0","rnacentral~0","orcid_data_claims~0","gpmdb~2","lineage-covid19~0","metagenomics~0","pfam~0","pride 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Experiment: Exp1, file: folder summary. Published as part of PLoS One. 2014 Feb 3;9(2):e87951  . From the Abstract: {{i}} We have compared the microsomal protein composition of eight malignant and six benign adrenocortical tumors with proteomic methods ... {{/i}}","dates":{"submission":"2014-02-13"},"accession":"GPM11210025579","cross_references":{"pubmed":["24498411"],"Pride":["PXD000604"],"pride":[],"Pride Archive":["PXD000604"]}}