{"database":"GPMDB","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":30,"searchCount":3},"additional":{"omics_type":["Other"],"submitter":["Duernberger G, et al."],"instrument_platform":["Instrument"],"disease":["Not Available"],"brenda_tissue":["Not available"],"species":["Mus_musculus_viruses, Mouse"],"submitter_mail":["gerhard.duernberger@imp.ac.at"],"publication":["Not available"],"submitter_affiliation":["IMP - Research Institute of Molecular Pathology, IMBA - Institute of Molecular Biotechnology"],"model":["http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210027561"],"cell_type":["Not available"],"repository":["GPMDB"],"name_synonyms":["Mdk4, MuSK, biological signaling, 2.7.10.1, Nsk3, signalling process, Nsk2, signaling process, Mlk, Nsk1, Muscle-specific kinase receptor, Muscle-specific tyrosine-protein kinase receptor, omicron-lactone, Muscle-specific tyrosine protein kinase receptor, 16-hydroxy-7-hexadecenoic acid, single organism signaling., signalling"],"description_synonyms":["projections, Proteoglycan, Sfrs5, Mdk4, MuSK, ZFYVE8, biological signaling, single-organism developmental process, JCAP, Myocytes, Effects, lamellae, Slpa, Eseptin, Myocyte, number, Muscle-specific tyrosine protein kinase receptor, biosynthesis, process of organ, presence, Long Term, protrusion, lamella, protein amino acid phosphorylation, period, B37, Muscle-specific kinase receptor, Proteoglycan Type H, Synapse, Hgr, Sint1, Effect, Muscle Cell, AF17q25, multicellular organismal biosynthetic process, study, D12S755E, single-organism biosynthetic process, skeletal, Receptor tyrosine kinase, formation, Longterm, anabolism, min, SFRS5, CACP, present in organism, ridges, Long-Term, Muscle Cells, synthesis, MSF, Msf, signalling pathway, 2.7.10.1, Mature Muscle Cell, signaling process, papilla, receptor agonist activity, omicron-lactone, Long-Term Effect, laminae, receptor tyrosine kinase, Long-Term Effects, single organism signaling, data, SeptD1, anatomical protrusion, Hrs, HRS, Mlk, USH3B, anatomical process, lamina, Longterm Effect, FNZ, flanges, DRPLA, FINC, HAPO, Muscle, LETS, CIG, development, Mature Muscle Cells, NOD, signaling cascade, count in organism, SINT1, count, Long Term Effects, shelf, PNUTL4, mixed synapse, ED-B, SRP40, signalling cascade, flange, organ process, NAPB, SZP, FN, shelves, Protein pp110, signaling molecule, 16-hydroxy-7-hexadecenoic acid, Mature, projection, ridge, signalling, Longterm Effects, process, processes, synaptic junction, Nsk3, signalling process, signaling pathway, Nsk2, spine, Nsk1, Muscle-specific tyrosine-protein kinase receptor, electrotonic synapse, processus, GFND2, GFND, regulation, MSF1, quantitative, SRp40., Proteomes, time, vitamin D receptor activator activity, presence or absence in organism"],"view_count":["30"],"citation_count":["0"],"full_dataset_link":["http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210027561"],"search_count":["3"],"search_domains":["dbgap_ncbi~0","patentfamilies~0","rfam~0","merops~0","complex-portal~0","uniprot~0","wormbaseparasite~0","embl-covid19~0","reactome~0","emdb~0","wgs_masters~0","ebiweb_resources~0","opentargets_genetics~0","biomodels_all~0","ipd-mhc~0","ebiweb_teams~0","taxonomy~0","genome_assembly~0","sc-experiments~0","ebiweb_people~0","enzymeportal_enzymes~0","ipd-nhkir~0","cellosaurus~0","pdbe~0","chebi~0","patentproteins~0","interpro7~0","uniref~0","chembl~0","pdbekb~0","gpcrdb~0","hgnc~0","sc-genes~0","intact~0","rhea~0","ebiweb_training~0","alphafold~0","imgt-hla~0","patentnucleotides~0","ensemblroot~0","eva_studies~0","non-coding~0","europepmc~0","identifiers_registry~0","pdbechem~0","hpa-covid19~0","eva-variants-covid19~0","biosamples~0","gwas_catalog~0","biotools~0","tls_masters~0","mesh~0","coding~0","sra~0","opentargets~0","efo~0","embl-pathogen~0","project~0","pride~1","human_diseases~0","geo_datasets~0","embl~0","treefam~0","uniparc~0","ols~0","dgva~0","intenz~0","go~0","tsa_masters~0","biosamples-covid19~0","ebiweb_corporate~0","omim~0","lrg~0","earlycause-molecular-sequences~0","ipd-kir~0","empiar~0","rnacentral~0","orcid_data_claims~0","gpmdb~1","lineage-covid19~0","metagenomics~0","pfam~0","pride archive~1","varsite~0"],"reanalysis_count":["0"],"submitter_keywords":["Resource Reanalysis"],"citation_count_scaled":["0.0"],"reanalysis_count_scaled":["0.0"],"view_count_scaled":["0.009253547193090685"],"download_count_scaled":["0.0"],"normalized_connections":["1.0"],"additional_accession":[]},"is_claimable":false,"name":"Phosphoproteomics of MuSK Signaling","description":"Data from ProteomeXchange, PXD ID: PXD000878. File: MuSK_proteome.msf. From ProteomeXchange: {{i}} The development of the neuromuscular synapse depends on signaling processes which involve protein phosphorylation as a crucial regulatory event. The receptor tyrosine kinase MuSK is the key signaling molecule at the neuromuscular synapse whose activity is required for the formation of a mature and functional neuromuscular synapse. However, the signaling cascade downstream of MuSK and the regulation of the different components is still poorly understood. Here we present data from a quantitative phosphoproteomics approach to study MuSK-dependent processes. Muscle cells were stimulated with the heparansulfate proteoglycan agrin, which activates MuSK and downstream signaling events. To get an insight into the signaling dynamics we used three different time points (unstimulated, 15 min, 60 min and 4 hrs). {{/i}}","dates":{"submission":"2014-06-05"},"accession":"GPM11210027561","cross_references":{"Pride":["PXD000878"],"pride":[],"Pride Archive":["PXD000878"]}}