{"database":"GPMDB","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":67,"searchCount":3},"additional":{"omics_type":["Other"],"submitter":["Sapkota G, et al."],"instrument_platform":["Instrument"],"disease":["Not Available"],"brenda_tissue":["Not available"],"species":["Homo_sapiens_viruses, Human"],"submitter_mail":["g.sapkota@dundee.ac.uk"],"publication":["Not available"],"submitter_affiliation":["MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee"],"model":["http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210037328"],"cell_type":["Not available"],"repository":["GPMDB"],"name_synonyms":["C77789, establishment and maintenance of substance location, Transphosphorylases, ubiquitin-specific protease activity, OTU1, ubiquitin hydrolase activity, AI850305, establishment and maintenance of cellular component location., CK2, Kinases, single-organism localization, Phosphotransferases, deubiquitylase, UCH2, UBP, single organism localization, deubiquitinating enzyme, 1110035J23Rik, deubiquitinase activity, localisation, Ck2, deubiquitinase, establishment and maintenance of position, OTB1, establishment and maintenance of localization, Kinase, establishment and maintenance of substrate location, ATP Phosphotransferases, ATP, ubiquitin C-terminal hydrolase activity"],"description_synonyms":["C77789, AI850305., neuronal nucleus, Transphosphorylases, data, OTU1, AI850305, CK2, Kinases, nucleus of CNS, Phosphorylations, pooled, blocked, nucleus of neuraxis, neuraxis nucleus, phosphorylation, Phosphotransferases, Cell, 1110035J23Rik, nucleus, nervous system nucleus, Ck2, horsetail nucleus, OTB1, Cytosols, cell nucleus, Kinase, ATP Phosphotransferases, ATP"],"view_count":["67"],"citation_count":["0"],"full_dataset_link":["http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210037328"],"search_count":["3"],"search_domains":["dbgap_ncbi~0","patentfamilies~0","rfam~0","merops~0","complex-portal~0","uniprot~0","wormbaseparasite~0","embl-covid19~0","reactome~0","emdb~0","wgs_masters~0","ebiweb_resources~0","opentargets_genetics~0","biomodels_all~0","ipd-mhc~0","ebiweb_teams~0","taxonomy~0","genome_assembly~0","sc-experiments~0","ebiweb_people~0","enzymeportal_enzymes~0","ipd-nhkir~0","cellosaurus~0","pdbe~0","chebi~0","patentproteins~0","interpro7~0","uniref~0","chembl~0","pdbekb~0","gpcrdb~0","hgnc~0","sc-genes~0","intact~0","rhea~0","ebiweb_training~0","alphafold~0","imgt-hla~0","patentnucleotides~0","ensemblroot~0","eva_studies~0","non-coding~0","europepmc~0","identifiers_registry~0","pdbechem~0","hpa-covid19~0","eva-variants-covid19~0","biosamples~0","gwas_catalog~0","biotools~0","tls_masters~0","mesh~0","coding~0","sra~0","opentargets~0","efo~0","embl-pathogen~0","project~0","pride~1","human_diseases~0","geo_datasets~0","embl~0","treefam~0","uniparc~0","ols~0","dgva~0","intenz~0","go~0","tsa_masters~0","biosamples-covid19~0","ebiweb_corporate~0","omim~0","lrg~0","earlycause-molecular-sequences~0","ipd-kir~0","empiar~0","rnacentral~0","orcid_data_claims~0","gpmdb~1","lineage-covid19~0","metagenomics~0","pfam~0","pride archive~1","varsite~0"],"reanalysis_count":["0"],"submitter_keywords":["Resource Reanalysis"],"citation_count_scaled":["0.0"],"reanalysis_count_scaled":["0.0"],"view_count_scaled":["0.02066625539790253"],"download_count_scaled":["0.0"],"normalized_connections":["1.0"],"additional_accession":[]},"is_claimable":false,"name":"Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localisation","description":"Data from ProteomeXchange, PXD ID: PXD001711. File: LHerhaus_120510_23.mzml. From ProteomeXchange: {{i}} The deubiquitylating enzyme OTUB1 is ubiquitously expressed and is known to target a multitude of substrates, both in the cytosol and nucleus. Here, we demonstrate that phosphorylation of OTUB1 by Casein kinase 2 (CK2) at Ser16 triggers its nuclear accumulation. CK2 phosphorylates OTUB1 at Ser16 in vitro. In cells, endogenous OTUB1 is phosphorylated at Ser16 and this is blocked by chemical and genetic ablation of CK2 activity. Whereas OTUB1 is detected mainly in the cytosol, OTUB1 phosphorylated at Ser16 is detected only in the nucleus. Inhibition of CK2 causes nuclear exclusion of OTUB1 ... {{/i}}","dates":{"submission":"2015-04-17"},"accession":"GPM11210037328","cross_references":{"Pride":["PXD001711"],"pride":[],"Pride Archive":["PXD001711"]}}