GPMDB00195OtherSghaier H, et al.InstrumentNot AvailableNot availableBlastococcus_saxobsidens_dd2jean.armengaud@cea.fr26125681National Center for Nuclear Sciences and Technology, Sidi Thabet Technopark, Ariana, Tunisia, et al.http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210040663http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210040664http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210040654http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210040665http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210040666http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210040655http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210040667http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210040656Not availableGPMDBThe Geodermatophilaceae are unique model systems to study the ability to thrive on or within stones and their proteogenomes (referring to the whole protein arsenal encoded by the genome) could provide important insight into their adaptation mechanisms. Here we report the detailed comparative genome analysis of Blastococcus saxobsidens (Bs), Modestobacter marinus (Mm) and Geodermatophilus obscurus (Go) isolated respectively from the interior and the surface of calcarenite stones and from desert sandy soils. The genome-scale analysis of Bs, Mm and Go illustrates how adaptation to these niches can be achieved through various strategies including 'molecular tinkering/opportunism' as shown by the high proportion of lost, duplicated or horizontally transferred genes and ORFans. Using high-throughput discovery proteomics, the three proteomes under unstressed conditions were analyzed, highlighting the most abundant biomarkers and the main protein factors. Proteomic data corroborated previously demonstrated stone-related ecological distribution. For instance, these data showed starvation-inducible, biofilm-related and DNA-protection proteins as signatures of the microbes associated with the interior, surface and outside of stones, respectively.Stone-dwelling actinobacteria Blastococcus saxobsidens, Modestobacter marinus and Geodermatophilus obscurus proteogenomes.Sghaier Haïtham H,Hezbri Karima K,Ghodhbane-Gtari Faten F,Pujic Petar P,Sen Arnab A,Daffonchio Daniele D,Boudabous Abdellatif A,Tisa Louis S LS,Klenk Hans-Peter HP,Armengaud Jean J,Normand Philippe P,Gtari Maher M,Sghaier Haïtham H, Hezbri Karima K, Ghodhbane-Gtari Faten F, Pujic Petar P, Sen Arnab A, Daffonchio Daniele D, Boudabous Abdellatif A, Tisa Louis S LS, Klenk Hans-Peter HP, Armengaud Jean J, Normand Philippe P, Gtari Maher Mst, High GC gram-positive bacteria, Actinobacteraeota, High G+C Gram-Positive Bacteria., Actinomycetes, Gram-Positive Bacteria, High G+CAP1, study, polypeptide, Junc, data, surface, integumentum commune., external covering of organism, Genomes, determination, integumentary system, body surface, AP-1, chemical analysis, c-jun, c-Jun, assay, proteins, organism surface, whole genome, dermal systemst, High GC gram-positive bacteria, Actinobacteraeota, High G+C Gram-Positive Bacteria., Actinomycetes, Gram-Positive Bacteria, High G+Cscale tissue, Viral Marker, Biological Markers, Materials, Surrogate Endpoints, DNS, determination, (Deoxyribonucleotide)n, Clinical Markers, Laboratory, Clinical Marker, supply, peltate hair, Biochemical, Gene, Endpoint, Yperite, Serum, Deoxyribonucleic acids, Surrogate End Points, Surrogate Markers, surface, Laboratory Markers, Deoxyribonucleic Acid, Biological, Famines, Gene Products, 1, 1'-thiobis(2-chloroethane), integumentum commune, study, proportion, doubled, thymus nucleic acid, Genetic, Clinical, pattern, Genomes, distribution, plant peltate hair, Biological Marker, Famine, Double Stranded, proteins, Lost, bis(2-chloroethyl) sulphide, st, Immunologic Markers, Immune, Markers, 1-chloro-2-[(2-chloroethyl)sulfanyl]ethane, Viral Markers, mustard gas, Double-Stranded DNA, (Deoxyribonucleotide)m, deoxyribonucleic acids, DNAn, associated, InChIKey=QKSKPIVNLNLAAV-UHFFFAOYAK, Immunologic Marker, Biologic, sulfur mustard, ratio, data, Viral, external covering of organism, Surrogate Endpoint, 1-chloro-2-[(2-chloroethyl)thio]ethane, DNAn+1, InChI=1/C4H8Cl2S/c5-1-3-7-4-2-6/h1-4H2, Serum Markers, Proteins, End Point, organism surface, Biochemical Markers, Double-Stranded, Cistrons, Biologic Marker, ClCCSCCCl, Immune Marker, (Deoxyribonucleotide)n+m, polypeptide, bis(2-chloroethyl)sulfane, Marker, Surrogate End Point, chemical analysis, Protein, Genetic Materials, supply and distribution, scales, ds-DNA, Starvations, Biofilm, desoxyribose nucleic acid, Genetic Material, Biologic Markers, Serum Marker, integumentum commune., scale, End Points, body surface, Surrogate, Endpoints, proportionality, Senfgas, deoxyribonucleic acid, rate, whole genome, Immunologic, Laboratory Marker, Surrogate Marker, Protein Gene Products, Gene Proteins, integumentary system, Material, Biochemical Marker, ds DNA, C4H8Cl2S, quotient, Desoxyribonukleinsaeure, Cistron, assay, DNA, dermal system, Proteomes, Immune Markers1905http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM11210040665dbgap_ncbi~0patentfamilies~0rfam~0merops~0complex-portal~0uniprot~0wormbaseparasite~0embl-covid19~0reactome~0emdb~0wgs_masters~0ebiweb_resources~0opentargets_genetics~0biomodels_all~0ipd-mhc~0ebiweb_teams~0taxonomy~0genome_assembly~0sc-experiments~0ebiweb_people~0enzymeportal_enzymes~0ipd-nhkir~0cellosaurus~0pdbe~0chebi~0patentproteins~0interpro7~0uniref~0chembl~0pdbekb~0gpcrdb~0hgnc~0sc-genes~0intact~0rhea~0ebiweb_training~0alphafold~0imgt-hla~0patentnucleotides~0ensemblroot~0eva_studies~0non-coding~0europepmc~0pubmed~1identifiers_registry~0pdbechem~0hpa-covid19~0eva-variants-covid19~0biosamples~0gwas_catalog~0biotools~0tls_masters~0mesh~0coding~0sra~0opentargets~0efo~0embl-pathogen~0project~0pride~1human_diseases~0geo_datasets~0embl~0treefam~0uniparc~0ols~0dgva~0intenz~0go~0tsa_masters~0biosamples-covid19~0ebiweb_corporate~0omim~0lrg~0earlycause-molecular-sequences~0ipd-kir~0empiar~0rnacentral~0orcid_data_claims~0gpmdb~2lineage-covid19~0metagenomics~0pfam~0pride archive~1varsite~00Resource Reanalysis0.00.00.0058605798889574340.01.0falseStone-dwelling actinobacteria Blastococcus saxobsidens, Modestobacter marinus and Geodermatophilus obscurus proteogenomes.Data from ProteomeXchange, PXD ID: PXD001519. File: Ech3-B3-proteom.mzml. Published as part of ISME J. 2015 Jun 30 . From the Abstract: {{i}} The Geodermatophilaceae are unique model systems to study the ability to thrive on or within stones and their proteogenomes (referring to the whole protein arsenal encoded by the genome) could provide important insight into their adaptation mechanisms. Here we report the detailed comparative genome analysis of Blastococcus saxobsidens (Bs), Modestobacter marinus (Mm) and Geodermatophilus obscurus (Go) isolated respectively from the interior and the surface of calcarenite stones and from desert sandy soils ... {{/i}}2015-08-03GPM1121004066526125681PXD001519PXD001519