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available"],"repository":["GPMDB"],"pubmed_abstract":["Macrophages operate at the forefront of innate immunity and their discrimination of foreign versus \"self\" particles is critical for a number of responses including efficient pathogen killing, antigen presentation, and cytokine induction. In order to efficiently destroy the particles and detect potential threats, macrophages express an array of receptors to sense and phagocytose prey particles. In this study, we accurately quantified a proteomic time-course of isolated phagosomes from murine bone marrow-derived macrophages induced by particles conjugated to seven different ligands representing pathogen-associated molecular patterns, immune opsonins or apoptotic cell markers. We identified a clear functional differentiation over the three timepoints and detected subtle differences between certain ligand-phagosomes, indicating that triggering of receptors through a single ligand type has mild, but distinct, effects on phagosome proteome and function. Moreover, our data shows that uptake of phosphatidylserine-coated beads induces an active repression of NF-κB immune responses upon Toll-like receptor (TLR)-activation by recruitment of anti-inflammatory regulators to the phagosome. This data shows for the first time a systematic time-course analysis of bone marrow-derived macrophages phagosomes and how phagosome fate is regulated by the receptors triggered for phagocytosis."],"pubmed_title":["Quantitative proteome analysis of temporally resolved phagosomes following uptake via key phagocytic receptors."],"pubmed_authors":["Dill Brian D BD,Gierlinski Marek M,Härtlova Anetta A,Arandilla Alba González AG,Guo Manman M,Clarke Rosemary G RG,Trost Matthias M,","Dill Brian D BD, Gierlinski Marek M, Härtlova Anetta A, Arandilla Alba González AG, Guo Manman M, Clarke Rosemary G RG, Trost Matthias M"],"name_synonyms":["count in organism, Phagolysosomes, uptake., count, determination, Phagosome, chemical analysis, number, Phagolysosome, assay, quantitative, Proteomes, presence, presence or absence in organism"],"description_synonyms":["data, kidney marrow, mol, Effects, Monocyte Derived Macrophages, Longterm Effect, Phosphoglycerides, Monocyte Derived, Cell, Long Term, 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Derived Macrophages, Effects, nonspecific immune response, number, Receptors, A4, TYPE, Long Term, DAGA4, period, medulla ossea, Marrow, Monocyte-Derived Macrophage, fam:TLR, Phosphatidyl, Yellow, Toll Like, MAM, phagosome, Effect, SCG3, study, Toll Like Receptor, Phagolysosomes, functional differentiation, head kidney, Longterm, Phagosome, cell, FATE, ligand, Phagolysosome, Bone Marrow-Derived Macrophage, number of, Long-Term, Bone marrow part, Toll Like Receptors, Red Marrow, Bone Marrow-Derived, has or lacks parts of type, Red, Long-Term Effect, associated, Long-Term Effects, Antigen Processings, antigen presentation, data, life termination, Longterm Effect, innate immunity, Toll-Like Receptor, Monocyte Derived, extra or missing physical or functional parts, function, Phosphoglycerides, antigen processing, Cell, death status type, LGMD2C, mereological quality, Antigen Presentations, Monocyte-Derived, uptake, Serines, anterior kidney, sacrifice, medulla ossium, Long Term Effects, chemical analysis, CT43, Serine Phosphoglycerides, activation, Monocyte-Derived Macrophages, Macrophage, Yellow Marrow, Serine, Toll-Like, DMDA1, distinct, Macrophages, medullary bone, medulla of bone, Phosphatidyl Serines, Bone Marrow Derived Macrophages, Phosphatidylserine, Longterm Effects, DMDA, Phagocytoses., clear, cardinality, SCARMD2, Bone Marrow-Derived Macrophages, Antigen Processing, microarray, Receptor, assay, time, Bone, Proteomes, Phosphatidyl 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File: BMM_30-30_Phosphatidylserine-3.mzml. Published as part of Mol Cell Proteomics. 2015 May;14(5):1334-49  . From the Abstract: {{i}} ... In this study, we accurately quantified a proteomic time-course of isolated phagosomes from murine bone marrow-derived macrophages induced by particles conjugated to seven different ligands representing pathogen-associated molecular patterns, immune opsonins or apoptotic cell markers ... {{/i}}","dates":{"submission":"2015-09-12"},"accession":"GPM11210041625","cross_references":{"pubmed":["25755298"],"Pride":["PXD000772"],"pride":[],"Pride Archive":["PXD000772"]}}