{"database":"GPMDB","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":13,"searchCount":4},"additional":{"omics_type":["Other"],"submitter":["Naba A, et al."],"instrument_platform":["Instrument"],"disease":["Not Available"],"brenda_tissue":["Not available"],"species":["Homo_sapiens_viruses, Human"],"publication":["25037231"],"submitter_mail":["Not available"],"model":["http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001620","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002432","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001587","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001586","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002433","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002434","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001622","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001589","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001588","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002435","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001621","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001624","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002436","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002437","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001623","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001626","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002438","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001625","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002439","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001581","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001580","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001583","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001582","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002430","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001585","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002431","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001584","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001628","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001627","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001629","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001598","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002421","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001631","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001630","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002422","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001597","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001633","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002423","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001599","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002424","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001632","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001635","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002425","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001634","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002426","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001637","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002427","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002428","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001636","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001590","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001592","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001591","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001594","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001593","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001596","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001595","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002429","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002454","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002455","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002456","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002457","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002458","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002459","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002450","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002451","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002452","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002453","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002443","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002444","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002445","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002446","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002447","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002448","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002449","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002440","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002441","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002442","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001539","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002476","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001543","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001542","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002477","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002478","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001545","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002479","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001544","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001547","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001546","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001549","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001548","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002470","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002471","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002472","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002473","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001541","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002474","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002475","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001540","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001554","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002465","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002466","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001553","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001556","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002467","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002468","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001555","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002469","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001558","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001557","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001559","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002460","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002461","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001550","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002462","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001552","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002463","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001551","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002464","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001565","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001564","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001567","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001600","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001566","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001569","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001602","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001601","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001568","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001604","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001603","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002490","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002491","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002492","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002493","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002494","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001561","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002495","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001560","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002496","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001563","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002497","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001562","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001606","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001605","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001608","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001607","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001609","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001576","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002487","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002488","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001575","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001611","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001578","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002489","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001577","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001610","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001613","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001612","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001579","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001615","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001614","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002480","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002481","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001570","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002482","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001572","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002483","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001571","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002484","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002485","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001574","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002486","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001617","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001616","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001619","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320001618"],"submitter_affiliation":["Broad Institute of MIT and Harvard"],"cell_type":["Not available"],"repository":["GPMDB"],"pubmed_abstract":["We have used enrichment of extracellular matrix (ECM) from human patient samples and proteomics to define the ECM composition of primary colon carcinomas and their metastases to liver in comparison with normal colon and liver samples.","Colorectal cancer is the third most frequently diagnosed cancer and the third cause of cancer deaths in the United States. Despite the fact that tumor cell-intrinsic mechanisms controlling colorectal carcinogenesis have been identified, novel prognostic and diagnostic tools as well as novel therapeutic strategies are still needed to monitor and target colon cancer progression. We and others have previously shown, using mouse models, that the extracellular matrix (ECM), a major component of the tumor microenvironment, is an important contributor to tumor progression. In order to identify candidate biomarkers, we sought to define ECM signatures of metastatic colorectal cancers and their metastases to the liver.","We show that robust signatures of ECM proteins characteristic of each tissue, normal and malignant, can be defined using relatively small samples from small numbers of patients. Comparisons with gene expression data from larger cohorts of patients confirm the association of subsets of the proteins identified by proteomic analysis with tumor progression and metastasis.","The ECM protein signatures of metastatic primary colon carcinomas and metastases to liver defined in this study, offer promise for development of diagnostic and prognostic signatures of metastatic potential of colon tumors. The ECM proteins defined here represent candidate serological or tissue biomarkers and potential targets for imaging of occult metastases and residual or recurrent tumors and conceivably for therapies. Furthermore, the methods described here can be applied to other tumor types and can be used to investigate other questions such as the role of ECM in resistance to therapy.","Colorectal cancer is the third most frequently diagnosed cancer and the third cause of cancer deaths in the United States. Despite the fact that tumor cell-intrinsic mechanisms controlling colorectal carcinogenesis have been identified, novel prognostic and diagnostic tools as well as novel therapeutic strategies are still needed to monitor and target colon cancer progression. We and others have previously shown, using mouse models, that the extracellular matrix (ECM), a major component of the tumor microenvironment, is an important contributor to tumor progression. In order to identify candidate biomarkers, we sought to define ECM signatures of metastatic colorectal cancers and their metastases to the liver.We have used enrichment of extracellular matrix (ECM) from human patient samples and proteomics to define the ECM composition of primary colon carcinomas and their metastases to liver in comparison with normal colon and liver samples.We show that robust signatures of ECM proteins characteristic of each tissue, normal and malignant, can be defined using relatively small samples from small numbers of patients. Comparisons with gene expression data from larger cohorts of patients confirm the association of subsets of the proteins identified by proteomic analysis with tumor progression and metastasis.The ECM protein signatures of metastatic primary colon carcinomas and metastases to liver defined in this study, offer promise for development of diagnostic and prognostic signatures of metastatic potential of colon tumors. The ECM proteins defined here represent candidate serological or tissue biomarkers and potential targets for imaging of occult metastases and residual or recurrent tumors and conceivably for therapies. Furthermore, the methods described here can be applied to other tumor types and can be used to investigate other questions such as the role of ECM in resistance to therapy.","<h4>Background</h4>Colorectal cancer is the third most frequently diagnosed cancer and the third cause of cancer deaths in the United States. Despite the fact that tumor cell-intrinsic mechanisms controlling colorectal carcinogenesis have been identified, novel prognostic and diagnostic tools as well as novel therapeutic strategies are still needed to monitor and target colon cancer progression. We and others have previously shown, using mouse models, that the extracellular matrix (ECM), a major component of the tumor microenvironment, is an important contributor to tumor progression. In order to identify candidate biomarkers, we sought to define ECM signatures of metastatic colorectal cancers and their metastases to the liver.<h4>Methods</h4>We have used enrichment of extracellular matrix (ECM) from human patient samples and proteomics to define the ECM composition of primary colon carcinomas and their metastases to liver in comparison with normal colon and liver samples.<h4>Results</h4>We show that robust signatures of ECM proteins characteristic of each tissue, normal and malignant, can be defined using relatively small samples from small numbers of patients. Comparisons with gene expression data from larger cohorts of patients confirm the association of subsets of the proteins identified by proteomic analysis with tumor progression and metastasis.<h4>Conclusions</h4>The ECM protein signatures of metastatic primary colon carcinomas and metastases to liver defined in this study, offer promise for development of diagnostic and prognostic signatures of metastatic potential of colon tumors. The ECM proteins defined here represent candidate serological or tissue biomarkers and potential targets for imaging of occult metastases and residual or recurrent tumors and conceivably for therapies. Furthermore, the methods described here can be applied to other tumor types and can be used to investigate other questions such as the role of ECM in resistance to therapy."],"pubmed_title":["Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver."],"pubmed_authors":["Naba Alexandra A,Clauser Karl R KR,Whittaker Charles A CA,Carr Steven A SA,Tanabe Kenneth K KK,Hynes Richard O RO,","Naba Alexandra A, Clauser Karl R KR, Whittaker Charles A CA, Carr Steven A SA, Tanabe Kenneth K KK, Hynes Richard O RO"],"name_synonyms":["Omental Appendix, Homo sapients, human being, Matrix, Humo sapiens, posterior intestine, iecur, Appendices, posterior intestine - zebrafish, Omental, Homo sapiense, Matrices, man, Homo sapines, Appendix Epiploica, human, hindgut, jecur, Livers, Homo spaiens, metastatic, Homo spiens, \"human\" EXACT genbank_common_name [], Homo sapien, large bowel, Homo sapience, COLON, Homo sapian, Homo sampiens, Entire colon, Taenia Coli, Extracellular, Homo sapians, Appendix, Entire liver., Extracellular Matrices, Homo sapeins, Home sapiens, Omental Appendices, proteinaceous extracellular matrix"],"description_synonyms":["data, human being, Malignant Neoplasm, Entire liver, Matrix, posterior intestine - zebrafish, Normalcy, Homo sapiense, compositionality, Matrices, composed of, Appendix Epiploica, hindgut, EMILIN4, jecur, Homo spaiens, Experiment, Homo sapien, large bowel, Homo sapian, Taenia Coli, Homo sapians, Appendix, Extracellular Matrices, Homo sapeins, Omental Appendices, malignant tumour, Normalities, average, Omental Appendix, Homo sapients, Normality, content, N, malignant neoplasia, Humo sapiens, posterior intestine, iecur, Appendices, composition, patient, Cancers, Omental, man, Homo sapines, malignant tumor, human, Livers, Homo spiens, Health, \"human\" EXACT genbank_common_name [], GPIa*, Homo sapience, COLON, Homo sampiens, Entire colon, Extracellular, ECM, structure, Entire liver., MMRN, Home sapiens, proteinaceous extracellular matrix, Cancer"],"pubmed_title_synonyms":["Omental Appendix, Homo sapients, human being, Matrix, Humo sapiens, posterior intestine, iecur, Appendices, posterior intestine - zebrafish, Omental, Homo sapiense, Matrices, man, Homo sapines, Appendix Epiploica, human, hindgut, jecur, Livers, Homo spaiens, metastatic, Homo spiens, \"human\" EXACT genbank_common_name [], Homo sapien, large bowel, Homo sapience, COLON, Homo sapian, Homo sampiens, Entire colon, Taenia Coli, Extracellular, Homo sapians, Appendix, Entire liver., Extracellular Matrices, Homo sapeins, Home sapiens, Omental Appendices, proteinaceous extracellular matrix"],"pubmed_abstract_synonyms":["human being, Entire liver, Matrix, posterior intestine - zebrafish, Normalcy, Homo sapiense, compositionality, Matrices, composed of, Appendix Epiploica, hindgut, EMILIN4, jecur, Homo spaiens, Homo sapien, large bowel, Homo sapian, Taenia Coli, Homo sapians, Appendix, Extracellular Matrices, Homo sapeins, Omental Appendices, Normalities, average, Omental Appendix, Homo sapients, Normality, content, N, Humo sapiens, posterior intestine, iecur, Appendices, composition, patient, Omental, man, Homo sapines, human, Livers, Homo spiens, Health, \"human\" EXACT genbank_common_name [], GPIa*, Homo sapience, COLON, Homo sampiens, Entire colon, Extracellular, ECM, structure, Entire liver., MMRN, Home sapiens, proteinaceous extracellular matrix"],"view_count":["13"],"citation_count":["0"],"search_count":["4"],"full_dataset_link":["http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310002460"],"search_domains":["dbgap_ncbi~0","patentfamilies~0","rfam~0","merops~0","complex-portal~0","uniprot~0","wormbaseparasite~0","embl-covid19~0","reactome~0","emdb~0","wgs_masters~0","ebiweb_resources~0","opentargets_genetics~0","biomodels_all~0","ipd-mhc~0","ebiweb_teams~0","taxonomy~0","genome_assembly~0","sc-experiments~0","ebiweb_people~0","enzymeportal_enzymes~0","ipd-nhkir~0","cellosaurus~0","pdbe~0","chebi~0","patentproteins~0","interpro7~0","uniref~0","chembl~0","pdbekb~0","gpcrdb~0","hgnc~0","sc-genes~0","intact~0","rhea~0","ebiweb_training~0","alphafold~0","imgt-hla~0","patentnucleotides~0","ensemblroot~0","eva_studies~0","non-coding~0","europepmc~0","pubmed~1","identifiers_registry~0","pdbechem~0","massive~1","hpa-covid19~0","eva-variants-covid19~0","biosamples~0","gwas_catalog~0","biotools~0","tls_masters~0","mesh~0","coding~0","sra~0","opentargets~0","efo~0","embl-pathogen~0","project~0","human_diseases~0","geo_datasets~0","embl~0","treefam~0","uniparc~0","ols~0","dgva~0","intenz~0","go~0","tsa_masters~0","biosamples-covid19~0","ebiweb_corporate~0","omim~0","lrg~0","earlycause-molecular-sequences~0","ipd-kir~0","empiar~0","rnacentral~0","orcid_data_claims~0","gpmdb~2","lineage-covid19~0","metagenomics~0","pfam~0","varsite~0"],"reanalysis_count":["0"],"submitter_keywords":["Resource Reanalysis"],"citation_count_scaled":["0.0"],"reanalysis_count_scaled":["0.0"],"view_count_scaled":["0.004009870450339297"],"download_count_scaled":["0.0"],"normalized_connections":["1.0"],"additional_accession":[]},"is_claimable":false,"name":"Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.","description":"Data from MASSIVE, MSV000078555. Experiment: D120204_CoN_2207, file: D120204_MGH_2207_OGE07_rafkt_ft8dt_cc_01.mzml. Published as part of BMC Cancer. 2014 Jul 18;14(1):518  . From the Abstract: {{i}} We have used enrichment of extracellular matrix (ECM) from human patient samples and proteomics to define the ECM composition of primary colon carcinomas and their metastases to liver in comparison with normal colon and liver samples. {{/i}}","dates":{"submission":"2014-07-22"},"accession":"GPM32310002460","cross_references":{"pubmed":["25037231"],"Massive":["MSV000078555"]}}