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Multiple Sclerosis Center of Excellence - East, Washington, DC, USA, et al."],"cell_type":["Not available"],"repository":["GPMDB"],"pubmed_abstract":["Susceptibility to multiple sclerosis (MS) is determined by environmental and genetic factors, but the cause remains unknown. Changes to the proteome prior to first symptom onset may reflect the underlying pathophysiology of the disease.","Compared with healthy controls, differential proteomic changes were noted in the serum of patients with MS that preceded the onset of symptomatic disease. Further work is in progress to confirm or refute these findings.","The mean intervals between first symptom onset and the collection of pre-symptomatic and post-symptomatic sera were -6.0 and +1.1 years, respectively. Pre-symptomatic proteins from the MS group were differentially regulated compared with both control groups indicating that proteomic changes are detected prior to symptom onset. Pathway analysis showed that proteins involved in the complement and coagulation pathways and lipid transport are significantly altered in the serum of subjects with MS compared with healthy donors.","This preliminary study utilized pre-symptomatic and post-symptomatic serum from a sample of 100 incident population-based US military veterans with MS along with 100 matched healthy controls. All samples were obtained from the Department of Defense Serum Repository. Multidimensional protein identification technology tandem mass spectrometry analysis was performed on tryptic peptides of lectin-captured glycosylated serum proteins following albumin/immunoglobulin G depletion. Identified proteins were analyzed with the Ingenuity Pathway Analysis program.","Susceptibility to multiple sclerosis (MS) is determined by environmental and genetic factors, but the cause remains unknown. Changes to the proteome prior to first symptom onset may reflect the underlying pathophysiology of the disease.This preliminary study utilized pre-symptomatic and post-symptomatic serum from a sample of 100 incident population-based US military veterans with MS along with 100 matched healthy controls. All samples were obtained from the Department of Defense Serum Repository. Multidimensional protein identification technology tandem mass spectrometry analysis was performed on tryptic peptides of lectin-captured glycosylated serum proteins following albumin/immunoglobulin G depletion. Identified proteins were analyzed with the Ingenuity Pathway Analysis program.The mean intervals between first symptom onset and the collection of pre-symptomatic and post-symptomatic sera were -6.0 and +1.1 years, respectively. Pre-symptomatic proteins from the MS group were differentially regulated compared with both control groups indicating that proteomic changes are detected prior to symptom onset. Pathway analysis showed that proteins involved in the complement and coagulation pathways and lipid transport are significantly altered in the serum of subjects with MS compared with healthy donors.Compared with healthy controls, differential proteomic changes were noted in the serum of patients with MS that preceded the onset of symptomatic disease. Further work is in progress to confirm or refute these findings.","<h4>Background and purpose</h4>Susceptibility to multiple sclerosis (MS) is determined by environmental and genetic factors, but the cause remains unknown. Changes to the proteome prior to first symptom onset may reflect the underlying pathophysiology of the disease.<h4>Methods</h4>This preliminary study utilized pre-symptomatic and post-symptomatic serum from a sample of 100 incident population-based US military veterans with MS along with 100 matched healthy controls. All samples were obtained from the Department of Defense Serum Repository. Multidimensional protein identification technology tandem mass spectrometry analysis was performed on tryptic peptides of lectin-captured glycosylated serum proteins following albumin/immunoglobulin G depletion. Identified proteins were analyzed with the Ingenuity Pathway Analysis program.<h4>Results</h4>The mean intervals between first symptom onset and the collection of pre-symptomatic and post-symptomatic sera were -6.0 and +1.1 years, respectively. Pre-symptomatic proteins from the MS group were differentially regulated compared with both control groups indicating that proteomic changes are detected prior to symptom onset. Pathway analysis showed that proteins involved in the complement and coagulation pathways and lipid transport are significantly altered in the serum of subjects with MS compared with healthy donors.<h4>Conclusions</h4>Compared with healthy controls, differential proteomic changes were noted in the serum of patients with MS that preceded the onset of symptomatic disease. Further work is in progress to confirm or refute these findings."],"pubmed_title":["Serum proteomic analysis of a pre-symptomatic multiple sclerosis cohort."],"pubmed_authors":["Wallin M T MT,Oh U U,Nyalwidhe J J,Semmes J J,Kislinger T T,Coffman P P,Kurtzke J F JF,Jacobson S S,","Wallin M T MT, Oh U U, Nyalwidhe J J, Semmes J J, Kislinger T T, Coffman P P, Kurtzke J F JF, Jacobson S S"],"name_synonyms":["\"multiple sclerosis\" EXACT [NCI2004_11_17:C3243], PRE, CPD photolyase activity, Disseminated Sclerosis, PhrB photolyase activity, Blood, Sclerosis, deoxyribonucleic cyclobutane dipyrimidine photolyase activity, Multiple Sclerosis, MS (Multiple Sclerosis), Blood Serum, Serum, pigmented retinal epithelium, photoreactivating enzyme activity, pigmented epithelium, deoxyribodipyrimidine photolyase activity, stratum pigmentosum retinae, stratum pigmentosum (retina), MS, \"Multiple sclerosis\" EXACT [SNOMEDCT_2005_07_31:155023009], retinal pigment, proteomic analysis, deoxyribonucleic photolyase activity, dipyrimidine photolyase (photosensitive), \"Generalized multiple sclerosis (disorder)\" EXACT [SNOMEDCT_2005_07_31:192928003], stratum pigmentosa retinae, MULTIPLE SCLEROSIS ACUTE FULMINATING, outer pigmented layer of retina, epithelium, retinal pigment layer, \"Multiple sclerosis (disorder)\" EXACT [SNOMEDCT_2005_07_31:24700007], \"Multiple sclerosis NOS (disorder)\" EXACT [SNOMEDCT_2005_07_31:192930001], RPE, deoxyribocyclobutadipyrimidine pyrimidine-lyase activity, photolyase activity, retinal pigmented epithelium, pigmented retina, \"insular sclerosis\" EXACT [CSP2005:2042-2324], retinal pigment epithelium, Disseminated, DNA cyclobutane dipyrimidine photolyase activity, Acute Fulminating, p. pigmentosa retinae, Multiple, phr A photolyase activity, pigment epithelium of retina, DNA-photoreactivating enzyme, pigmented retina epithelium, deoxyribonucleate pyrimidine dimer lyase (photosensitive), \"Multiple sclerosis\" EXACT [ICD9CM_2006:340]., Serums"],"description_synonyms":["PRE, CPD photolyase activity, data, PhrB photolyase activity, Blood, deoxyribonucleic cyclobutane dipyrimidine photolyase activity, Arts, Proteins, Gene, Blood Serum, Serum, pigmented retinal epithelium, photoreactivating enzyme activity, pigmented epithelium, deoxyribodipyrimidine photolyase activity, stratum pigmentosum retinae, polypeptide, School-Age, Polypeptides, stratum pigmentosum (retina), IgG3, retinal pigment, IgG4, IgG1, Gamma Globulin, IgG2, School Age, Protein, deoxyribonucleic photolyase activity, Gene Products, dipyrimidine photolyase (photosensitive), stratum pigmentosa retinae, outer pigmented layer of retina, epithelium, retinal pigment layer, study, School-Age Populations, Populations, Industrial, RPE, deoxyribocyclobutadipyrimidine pyrimidine-lyase activity, Industrial Arts, IgG, Identification, IgG(T), Immunoglobulin GT, photolyase activity, retinal pigmented epithelium, Polyglobin, pigmented retina, Identifications (Psychology), proteins, Population, retinal pigment epithelium, School Age Populations, Veteran, DNA cyclobutane dipyrimidine photolyase activity, sample population, p. pigmentosa retinae, Protein Gene Products, Gene Proteins, phr A photolyase activity, pigment epithelium of retina, DNA-photoreactivating enzyme, IgG2A, sample, IgG2B, GT, 7S Gamma Globulin, pigmented retina epithelium, Allerglobuline, deoxyribonucleate pyrimidine dimer lyase (photosensitive), School-Age Population, School Age Population, Serums, 7S, Immunoglobulin."],"pubmed_title_synonyms":["\"multiple sclerosis\" EXACT [NCI2004_11_17:C3243], PRE, CPD photolyase activity, Disseminated Sclerosis, PhrB photolyase activity, Blood, Sclerosis, deoxyribonucleic cyclobutane dipyrimidine photolyase activity, Multiple Sclerosis, MS (Multiple Sclerosis), Blood Serum, Serum, pigmented retinal epithelium, photoreactivating enzyme activity, pigmented epithelium, deoxyribodipyrimidine photolyase activity, stratum pigmentosum retinae, stratum pigmentosum (retina), MS, \"Multiple sclerosis\" EXACT [SNOMEDCT_2005_07_31:155023009], retinal pigment, proteomic analysis, deoxyribonucleic photolyase activity, dipyrimidine photolyase (photosensitive), \"Generalized multiple sclerosis (disorder)\" EXACT [SNOMEDCT_2005_07_31:192928003], stratum pigmentosa retinae, MULTIPLE SCLEROSIS ACUTE FULMINATING, outer pigmented layer of retina, epithelium, retinal pigment layer, \"Multiple sclerosis (disorder)\" EXACT [SNOMEDCT_2005_07_31:24700007], \"Multiple sclerosis NOS (disorder)\" EXACT [SNOMEDCT_2005_07_31:192930001], RPE, deoxyribocyclobutadipyrimidine pyrimidine-lyase activity, photolyase activity, retinal pigmented epithelium, pigmented retina, \"insular sclerosis\" EXACT [CSP2005:2042-2324], retinal pigment epithelium, Disseminated, DNA cyclobutane dipyrimidine photolyase activity, Acute Fulminating, p. pigmentosa retinae, Multiple, phr A photolyase activity, pigment epithelium of retina, DNA-photoreactivating enzyme, pigmented retina epithelium, deoxyribonucleate pyrimidine dimer lyase (photosensitive), \"Multiple sclerosis\" EXACT [ICD9CM_2006:340]., Serums"],"pubmed_abstract_synonyms":["\"Multiple sclerosis (disorder)\" EXACT [SNOMEDCT_2005_07_31:24700007], \"multiple sclerosis\" EXACT [NCI2004_11_17:C3243], \"Multiple sclerosis NOS (disorder)\" EXACT [SNOMEDCT_2005_07_31:192930001], susceptibility, Disseminated Sclerosis, Multiple, human disease, MS, \"Multiple sclerosis\" EXACT [SNOMEDCT_2005_07_31:155023009], Diseases., Sclerosis, dysfunction, Multiple Sclerosis, \"Generalized multiple sclerosis (disorder)\" EXACT [SNOMEDCT_2005_07_31:192928003], Homo sapiens disease, \"insular sclerosis\" EXACT [CSP2005:2042-2324], MULTIPLE SCLEROSIS ACUTE FULMINATING, pathophysiology, MS (Multiple Sclerosis), \"Multiple sclerosis\" EXACT [ICD9CM_2006:340], Disseminated, Proteomes, Acute 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File: JS_serum_pools_23_step03.mzml. Data published as part of Eur J Neurol. 2014 Aug 7  . From the Abstract: {{i}} This preliminary study utilized pre-symptomatic and post-symptomatic serum from a sample of 100 incident population-based US military veterans with MS along with 100 matched healthy controls. All samples were obtained from the Department of Defense Serum Repository. Multidimensional protein identification technology tandem mass spectrometry analysis was performed on tryptic peptides of lectin-captured glycosylated serum proteins following albumin/immunoglobulin G depletion. {{/i}}","dates":{"submission":"2014-09-23"},"accession":"GPM32310003985","cross_references":{"pubmed":["25104396"],"Massive":["MSV000078865"]}}