GPMDB00125OtherJin-Gyun Lee, et al.InstrumentNot AvailableNot availableHomo_sapiens_viruses, Rhesus_monkey_papillomavirus_1_uid14025, Rhesussunil.hwang@carolinas.org25974132Proteomics Laboratory for Clinical and Translational Research, Carolinas HealthCare System, Charlotte, North Carolina, et al.http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310019946http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310019947http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310019944http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310019945http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310019939http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310019942http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310019940http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310019941Not availableGPMDBThough the rhesus monkey is one of the most valuable non-human primate animal models for various human diseases because of its manageable size and genetic and proteomic similarities with humans, proteomic research using rhesus monkeys still remains challenging due to the lack of a complete protein sequence database and effective strategy. To investigate the most effective and high-throughput proteomic strategy, comparative data analysis was performed employing various protein databases and search engines. The UniProt databases of monkey, human, bovine, rat and mouse were used for the comparative analysis and also a universal database with all protein sequences from all available species was tested. At the same time, de novo sequencing was compared to the SEQUEST search algorithm to identify an optimal work flow for monkey proteomics. Employing the most effective strategy, proteomic profiling of monkey organs identified 3,481 proteins at 0.5% FDR from 9 male and 10 female tissues in an automated, high-throughput manner. Data are available via ProteomeXchange with identifier PXD001972. Based on the success of this alternative interpretation of MS data, the list of proteins identified from 12 organs of male and female subjects will benefit future rhesus monkey proteome research.A draft map of rhesus monkey tissue proteome for biomedical research.Lee Jin-Gyun JG,McKinney Kimberly Q KQ,Lee Yong-Yook YY,Chung Hae-Na HN,Pavlopoulos Antonis J AJ,Jung Kook Y KY,Kim Woong-Ki WK,Kuroda Marcelo J MJ,Han David K DK,Hwang Sunil S,Lee Jin-Gyun JG, McKinney Kimberly Q KQ, Lee Yong-Yook YY, Chung Hae-Na HN, Pavlopoulos Antonis J AJ, Jung Kook Y KY, Kim Woong-Ki WK, Kuroda Marcelo J MJ, Han David K DK, Hwang Sunil Srhesus macaque, portion of tissue, RUTBC3, rabGAPLP, MUTYH-Associated Polyposis, "rhesus monkeys" EXACT common_name [], Research, "rhesus macaques" EXACT common_name [], Tissue, RabGAP-5, rhesus monkeys, rhesus macaques, MYH-Associated Polyposis, Experimental Medicine., "rhesus monkey" EXACT genbank_common_name [], RABGAP5, Biomedical, Investigative Medicine, Experimental, Investigative, RUSC3, Medical Research, Investigational Medicine, Medicine, Rhesus monkey, tissue portion, simple tissue, Medical, "rhesus macaque" EXACT common_name [], Proteomes, Investigational, MAPrhesus macaque, human being, multi-cellular organism, Activity, JCAP, determination, Laboratory, Slf, Slpa, Eseptin, Somatomedin-C, primate, rhesus monkeys, FPH2, http://mged.sourceforge.net/ontologies/MGEDOntology.owl#male, Homo sapiense, "Primata" RELATED synonym [], Human, Homo spaiens, Tier, Homo sapien, Homo sapiens, Homo sapians, Sint1, Research Activity, animal, Laboratory Research, Man, AF17q25, male, Priorities, Search Engines, Homo sapients, Man (Taxonomy), Research, somatomedin-C, male genitalia, SF, CACP, Kitl, metazoa, proteins, man, Mast cell growth factor, MSF, Msf, Homo sapience, IGF1, Homo sampiens, Mechano growth factor, Rhesus monkey, Soluble KIT ligand, Development and Research, Research Priority, Sl, Primate, Home sapiens, "primate" EXACT equivalent_name [], Primata, male genital system, IGF-I, data, Prostates, SeptD1, steel factor, "rhesus monkeys" EXACT common_name [], Males, "rhesus macaques" EXACT common_name [], body, hematopoietic growth factor KL, animalia, Modern, FNZ, somatomedin, Research Priorities, whole body, FINC, HAPO, Entire prostate, LETS, "primates" RELATED blast_name [], sKITLG, Engine, CIG, polypeptide, primates, organism, Experiment, SINT1, Priority, Homo sapian, male prostate, mechano growth factor, chemical analysis, Diseases, Research Activities, sequence, PNUTL4, ED-B, Homo sapeins, Igf-1, "rhesus macaque" EXACT common_name [], Data Base, Research and Development, NAPB, SHEP7, SZP, FN, whole organism, mast cell growth factor, Stem cell factor, Humo sapiens, rhesus macaques, STAT5, "rhesus monkey" EXACT genbank_common_name [], Homo sapines, human, primary structure of sequence macromolecule, male human body, Activities, stem cell factor, Homo spiens, KL-1, "human" EXACT genbank_common_name [], Search., MGF, Modern Man, c-Kit ligand, Koerper, KITLG, GFND2, GFND, MSF1, assay, SCF, prostate, humans, prostatarhesus macaque, portion of tissue, RUTBC3, rabGAPLP, MUTYH-Associated Polyposis, "rhesus monkeys" EXACT common_name [], Research, "rhesus macaques" EXACT common_name [], Tissue, RabGAP-5, rhesus monkeys, rhesus macaques, MYH-Associated Polyposis, Experimental Medicine., "rhesus monkey" EXACT genbank_common_name [], RABGAP5, Biomedical, Investigative Medicine, Experimental, Investigative, RUSC3, Medical Research, Investigational Medicine, Medicine, Rhesus monkey, tissue portion, simple tissue, Medical, "rhesus macaque" EXACT common_name [], Proteomes, Investigational, MAPrhesus macaque, 3.4.22.-, human being, multi-cellular organism, Activity, determination, Laboratory, Effects, Mus domesticus, primate, rhesus monkeys, Gene, mini-ICE, CASP-14, "Bos Tauurus" RELATED misspelling [], Homo sapiense, http://mged.sourceforge.net/ontologies/MGEDOntology.owl#male, "Primata" RELATED synonym [], House Mouse, Long Term, Human, "New World monkeys" EXACT genbank_common_name [], period, Homo spaiens, rat, Rattus sp. strain Wistar, Tier, Homo sapien, Rats, Homo sapiens, cattle, House, Mammals, "Rattus rattiscus" RELATED misnomer [], Homo sapians, Gene Products, Mus musculus domesticus, Norway rat, Rattus rattiscus, Research Activity, animal, Laboratory Research, Mice, Effect, Man, "Bos primigenius taurus" RELATED synonym [], male, Priorities, brown rat, "Gunn rats" RELATED misnomer [], Search Engines, Homo sapients, Man (Taxonomy), Research, New World monkeys, Longterm, Swiss, Bos bovis, Tissue, male genitalia, "brown rat" EXACT common_name [], Swiss Mice, metazoa, proteins, W, Long-Term, "Rattus norvegicus8" RELATED misspelling [], "mouse" EXACT common_name [], man, Research Activities., "bovine" EXACT common_name [], "monkey" EXACT common_name [], "Mus muscaris" RELATED misnomer [], Bos Tauurus, Homo sapience, Homo sampiens, Rhesus monkey, "mice C57BL/6xCBA/CaJ hybrid" RELATED misspelling [], domestic cow, Long-Term Effect, Development and Research, species, Research Priority, house mouse, Primate, Home sapiens, "primate" EXACT equivalent_name [], Long-Term Effects, Primata, Rattus norvegicus8, male genital system, monkey, data, "rhesus monkeys" EXACT common_name [], cow, female human body, "rhesus macaques" EXACT common_name [], body, Males, animalia, Modern, Proteins, mouse, Longterm Effect, Research Priorities, whole body, Search, "domestic cattle" EXACT common_name [], female, "primates" RELATED blast_name [], Engine, mice C57BL/6xCBA/CaJ hybrid, Mus muscaris, polypeptide, primates, organism, Priority, Rattus norwegicus, Mus, Homo sapian, Bos primigenius taurus, Algorithm, chemical analysis, Old World monkeys, Mini-ICE, Long Term Effects, Protein, Diseases, Research Activities, "rat" EXACT common_name [], sequence, monkeys, "Rattus sp. strain Wistar" EXACT equivalent_name [], domestic cattle, Homo sapeins, "monkeys" EXACT common_name [], "rhesus macaque" EXACT common_name [], "domestic cow" EXACT common_name [], Data Base, Research and Development, Mus musculus, http://mged.sourceforge.net/ontologies/MGEDOntology.owl#female, whole organism, "rats" EXACT common_name [], Caspase-14 subunit p10, mice, Swiss Mouse, Humo sapiens, "cattle" EXACT genbank_common_name [], rhesus macaques, House Mice, Caspase-14 subunit p19, MICE, "rhesus monkey" EXACT genbank_common_name [], Homo sapines, rats, human, primary structure of sequence macromolecule, Longterm Effects, Laboratory Mice, domesticus, Activities, "cow" EXACT common_name [], Protein Gene Products, male human body, "house mouse" EXACT genbank_common_name [], Gene Proteins, Homo spiens, "human" EXACT genbank_common_name [], "Norway rat" EXACT genbank_common_name [], Modern Man, Koerper, "Rattus norwegicus" RELATED misspelling [], "Bos bovis" RELATED synonym [], Mouse, assay, bovine, Laboratory Mouse, time, Proteomes, Females, humans, Gunn rats1205http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310019946dbgap_ncbi~0patentfamilies~0rfam~0merops~0complex-portal~0uniprot~0wormbaseparasite~0embl-covid19~0reactome~0emdb~0wgs_masters~0ebiweb_resources~0opentargets_genetics~0biomodels_all~0ipd-mhc~0ebiweb_teams~0taxonomy~0genome_assembly~0sc-experiments~0ebiweb_people~0enzymeportal_enzymes~0ipd-nhkir~0cellosaurus~0pdbe~0chebi~0patentproteins~0interpro7~0uniref~0chembl~0pdbekb~0gpcrdb~0hgnc~0sc-genes~0intact~0rhea~0ebiweb_training~0alphafold~0imgt-hla~0patentnucleotides~0ensemblroot~0eva_studies~0non-coding~0europepmc~0pubmed~1identifiers_registry~0pdbechem~0hpa-covid19~0eva-variants-covid19~0biosamples~0gwas_catalog~0biotools~0tls_masters~0mesh~0coding~0sra~0opentargets~0efo~0embl-pathogen~0project~0pride~1human_diseases~0geo_datasets~0embl~0treefam~0uniparc~0ols~0dgva~0intenz~0go~0tsa_masters~0biosamples-covid19~0ebiweb_corporate~0omim~0lrg~0earlycause-molecular-sequences~0ipd-kir~0empiar~0rnacentral~0orcid_data_claims~0gpmdb~2lineage-covid19~0metagenomics~0pfam~0pride archive~1varsite~00Resource Reanalysis0.00.00.0037014188772362740.01.0falseA draft map of rhesus monkey tissue proteome for biomedical research.Data from ProteomeXchange, PXD ID: PXD001972. Experiment: male, file: MALE_PROSTATE_MID.msf.mgf. Published as part of PLoS One. 2015 May 14;10(5):e0126243 . From the Abstract: {{i}} Though the rhesus monkey is one of the most valuable non-human primate animal models for various human diseases because of its manageable size and genetic and proteomic similarities with humans, proteomic research using rhesus monkeys still remains challenging due to the lack of a complete protein sequence database and effective strategy. To investigate the most effective and high-throughput proteomic strategy, comparative data analysis was performed employing various protein databases and search engines ... {{/i}}2015-05-20GPM3231001994625974132PXD001972PXD001972