GPMDB00195OtherMarie P, et al.InstrumentNot AvailableNot availableChicken26049031joel.gautron@tours.inra.fr.http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020421http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020542http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020422http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020543http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020544http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020423http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020545http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020424http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020540http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020420http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020541http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020429http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020546http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020425http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020426http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020547http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020548http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020427http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020428http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020549http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020432http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020553http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020433http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020554http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020434http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020555http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020556http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020435http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020550http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020430http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020551http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020431http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020552http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020557http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020436http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020558http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020437http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020559http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020438http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020439http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020480http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020481http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020482http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020487http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020520http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020521http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020488http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020522http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020489http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020523http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020483http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020484http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020485http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020528http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020529http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020524http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020525http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020526http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020527http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020490http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020491http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020492http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020493http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020531http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020498http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020499http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020532http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020533http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020534http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020494http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020495http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020496http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020530http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020497http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020418http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020539http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020419http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020535http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020415http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020536http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310020537http://g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UR83 Recherches avicoles, Fonction et Regulation des proteines de l--ufNot availableGPMDBEggshell is a bioceramic composed of 95% calcium carbonate mineral and 3.5% organic matrix. Its structural organisation is controlled by its organic matrix. We have used quantitative proteomics to study four key stages of shell mineralisation: 1) widespread deposition of amorphous calcium carbonate (ACC), 2) ACC transformation into crystalline calcite aggregates, 3) formation of larger calcite crystal units and 4) development of a columnar structure with preferential calcite crystal orientation. This approach explored the distribution of 216 shell matrix proteins found at the four stages. Variations in abundance according to these calcification events were observed for 175 proteins. A putative function related to the mineralisation process was predicted by bioinformatics for 77 of them and was further characterised. We confirmed the important role of lysozyme, ovotransferrin, ovocleidin-17 and ovocleidin-116 for shell calcification process, characterised major calcium binding proteins (EDIL3, ALB, MFGE8, NUCB2), and described novel proteoglycans core proteins (GPC4, HAPLN3). We suggest that OVAL and OC-17 play a role in the stabilisation of ACC. Finally, we report proteins involved in the regulation of proteins driving the mineralisation. They correspond to numerous molecular chaperones including CLU, PPIB and OCX21, protease and protease inhibitors including OVM and CST3, and regulators of phosphorylation.Quantitative proteomics provides new insights into chicken eggshell matrix protein functions during the primary events of mineralisation and the active calcification phase.Marie Pauline P,Labas Valérie V,Brionne Aurélien A,Harichaux Grégoire G,Hennequet-Antier Christelle C,Rodriguez-Navarro Alejandro B AB,Nys Yves Y,Gautron Joël J,Marie Pauline P, Labas Valérie V, Brionne Aurélien A, Harichaux Grégoire G, Hennequet-Antier Christelle C, Rodriguez-Navarro Alejandro B AB, Nys Yves Y, Gautron Joël Jchicken, calcinosis, PHYSIOL CALCIFICATION, macrocalcification, calcification., DEPOSIT(S), Gallus gallus domesticus, Physiologic, egg shell, number, Mineralization, Physiologic Calcification, proteins, calcareous, CALCIUM, Physiological Calcification, presence, polypeptide, Bone Mineralization, CALCIFICATION PHYSIOL, count in organism, count, Gallus domesticus, CALCIUM DEPOSIT(S), chickens, bantam, quantitative, Calcification, Bone, Physiological, presence or absence in organismMental, data, Controlling, Limestone, organisation, single-organism developmental process, Psychological Orientations, conformation, AP-1, egg shell, angular placement, c-jun, number, biosynthesis, compositionality, Mental Orientation, composed of, Chalk, presence, ACCA, development, count in organism, count, Carbonate, Cognitive Orientations, Marble, Orientation, plane angle., Orientations, shell, Mental Orientations, Calcium Milk, Cognitive Orientation, multicellular organismal biosynthetic process, Psychological, study, Junc, Calcium, single-organism biosynthetic process, angular magnitude, reference sample, formation, amount of rotation, anabolism, content, Carbonic acid calcium salt (1:1), composition, Milk of Calcium, angle, ACAC, Cognitive, ACACAD, synthesis, ACC, AP1, BMS1L, Psychological Orientation, Calcite, structure, ACC1, c-Jun, Aragonite, quantitative, relational structural quality, Vaterite, Controlled, presence or absence in organismchicken, calcinosis, PHYSIOL CALCIFICATION, macrocalcification, calcification., DEPOSIT(S), Gallus gallus domesticus, Physiologic, egg shell, number, Mineralization, Physiologic Calcification, proteins, calcareous, CALCIUM, Physiological Calcification, presence, polypeptide, Bone Mineralization, CALCIFICATION PHYSIOL, count in organism, count, Gallus domesticus, CALCIUM DEPOSIT(S), chickens, bantam, quantitative, Calcification, Bone, Physiological, presence or absence in organismprojections, ANALBA, APO-J, AA408962, single-organism developmental process, macrocalcification, OC-116, DEPOSIT(S), supply, egg shell, angular placement, Calcium 40, SED1, composed of, MFGM, ACCA, Chaperone, Roles, Orientation, Protease Inhibitor, Concepts, Inhibitors, AF311610, Hydrolase Inhibitors, ARMD11, Cognitive Orientation, 9530073D23Rik, multicellular organismal biosynthetic process, Psychological, calcio, single-organism biosynthetic process, angular magnitude, reference sample, Molecular, anabolism, Carbonic acid calcium salt (1:1), TRPM2, APOJ, composition, Physiologic Calcification, ApoJ, proteins, ACACAD, ACC, BMS1L, oval, ellipse-shaped, papilla, AI661372, Role Concepts, Aragonite, Trpmb, MFGME8, Mfgm, Nesfatin-1, PRO1341, Physiological, Blood Coagulation Factor IV, Ca, Lpr3, calcinosis, anatomical protrusion, Coagulation, organisation, Psychological Orientations, 4930554N11Rik, SPAG10, TRPM2B, lamina, flanges, AI325141, NEFA, Peptide Peptidohydrolase, Alb-1, predicted, Trpm2, Role Concept, HMFG, count, Playthings and Play, shelf, Role, Plaything, shell, CLU2, CLU1, plane angle, eccentric, OC-17, CypB, Antagonists, content, shelves, Calnuc, ovoid, P47, Toys, Milk of Calcium, elliptical, MFGMP-E8, projection, ridge, Bone Mineralization, Peptidase Inhibitors, spine, AGS, Antiproteases, Nefa, Endopeptidase, CYPB, Inhibitor, Bone, Proteoglycan, Mental, Cli, CLI, Plays, Limestone, conformation, lamellae, Endopeptidase Inhibitors, p54, CYP-S1, nucleocapsid, SGP2, number, Sgp2, egg-shaped, Gene, Protease, biosynthesis, Albza, Mental Orientation, Chalk, presence, process of organ, BA46, protrusion, lamella, Ovotransferrin, AA408458, CyP-20b, 20Ca, Factor IV, Gene Products, Proteoglycan Type H, Orientations, Peptide Hydrolase, KUB1, calcification, NA1|NA2, Toy, study, MP47, Calcium-40, FDAH, pattern, Playthings, formation, amount of rotation, distribution, Physiologic, ligand, AA553318, calcareous, CALCIUM, ridges, angle, SP-40, hP47, AI844835, PRO0883, synthesis, CysC, Puppets, Protease Antagonists, DAG, CALCIUM DEPOSIT(S), AI385680, Play, Peptide Peptidohydrolase Inhibitors, RATTRPM2B, Alb, AI607786, laminae, relational structural quality, Puppet, Controlled, EDIL1, Controlling, PHYSIOL CALCIFICATION, Alb1, Chaperones, Scylp, HEL-S-39, anatomical process, Proteins, D14Ucla3, MFG-E8, SGP-2, Phosphorylations, Sugp-2, Mineralization, PRO0903, function, Cphn-2, HEL-S-109, Molecular Chaperone, compositionality, Kalzium, Peptide, OI9, Concept, development, polypeptide, count in organism, Carbonate, Cognitive Orientations, Marble, Protein, ellipsoid, core, Mental Orientations, supply and distribution, Calcification, DEL1, Calcium Milk, flange, organ process, SP40, HsT19888, Calcium, HsT19883, lactadherin, EXLD1, FBF-1, Physiological Calcification, Peptidohydrolase Inhibitors, ACAC, Cognitive, Cphn2, K-glypican, Protein Gene Products, TRPM-2, Gene Proteins, process, processes, CALCIFICATION PHYSIOL, Sgp-2, Peptidase, Coagulation Factor IV, OAcGD3S, Psychological Orientation, Calcite, structure, ACC1, processus, regulation, AI893575, Peptide Hydrolase Inhibitors, phosphorylation., quantitative, Vaterite, SCYLP, presence or absence in 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archive~1varsite~00Resource Reanalysis0.00.00.0058605798889574340.01.0falseQuantitative proteomics provides new insights into chicken eggshell matrix protein functions during the primary events of mineralisation and the active calcification phase.Data from ProteomeXchange, PXD ID: PXD001450. File: 13-3105_Gautron_7h_1_ORBI486.mzML. Published as part of J Proteomics. 2015 Jun 3. pii: S1874-3919(15)30033-6 . From the Abstract: {{i}} Eggshell is a bioceramic composed of 95% calcium carbonate mineral and 3.5% organic matrix. Its structural organisation is controlled by its organic matrix. We have used quantitative proteomics to study four key stages of shell mineralisation: 1) widespread deposition of amorphous calcium carbonate (ACC), 2) ACC transformation into crystalline calcite aggregates, 3) formation of larger calcite crystal units 4) and development of a columnar structure with preferential calcite crystal orientation ... {{/i}}2015-06-09GPM3231002058626049031PXD001450PXD001450