GPMDB00213OtherLink A, et al.InstrumentNot AvailableNot availableYeastandrew.link@vanderbilt.eduNot availablehttp://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310021827http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310021825Vanderbilt UniversityNot availableGPMDBepistatic, epistatic genetic interaction (sensu inequality).PARK1, IGF-I, data, SeptD1, steel factor, Plays, SLEB2, JCAP, PARK4, Slf, Slpa, hematopoietic growth factor KL, Eseptin, Somatomedin-C, FNZ, somatomedin, FPH2, FINC, HAPO, LETS, results, sKITLG, CIG, Concept, SINT1, Role Concept, Playthings and Play, Roles, mechano growth factor, Role, Plaything, Concepts, PNUTL4, epistatic, atomus, atomo, ED-B, Sint1, epistatic genetic interaction (sensu inequality), Igf-1, atome, PD1, AF17q25, PD-1, suppressive genetic interaction (sensu inequality)., Toy, NAPB, study, NACP, SHEP7, SZP, FN, mast cell growth factor, Playthings, Stem cell factor, atoms, somatomedin-C, Toys, SF, CACP, Kitl, STAT5, CD279, Mast cell growth factor, hPD-1, MSF, Msf, stem cell factor, hPD-l, KL-1, Puppets, IGF1, PPP1R145, hSLE1, MGF, c-Kit ligand, Role Concepts, Mechano growth factor, Play, KITLG, GFND2, GFND, MSF1, Soluble KIT ligand, SCF, elements, tamo, Sl, Proteomes, atom, Puppet210http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM323100218273dbgap_ncbi~0patentfamilies~0rfam~0merops~0complex-portal~0uniprot~0wormbaseparasite~0embl-covid19~0reactome~0emdb~0wgs_masters~0ebiweb_resources~0opentargets_genetics~0biomodels_all~0ipd-mhc~0ebiweb_teams~0taxonomy~0genome_assembly~0sc-experiments~0ebiweb_people~0enzymeportal_enzymes~0ipd-nhkir~0cellosaurus~0pdbe~0chebi~0patentproteins~0interpro7~0uniref~0chembl~0pdbekb~0gpcrdb~0hgnc~0sc-genes~0intact~0rhea~0ebiweb_training~0alphafold~0imgt-hla~0patentnucleotides~0ensemblroot~0eva_studies~0non-coding~0europepmc~0identifiers_registry~0pdbechem~0hpa-covid19~0eva-variants-covid19~0biosamples~0gwas_catalog~0biotools~0tls_masters~0mesh~0coding~0sra~0opentargets~0efo~0embl-pathogen~0project~0pride~1human_diseases~0geo_datasets~0embl~0treefam~0uniparc~0ols~0dgva~0intenz~0go~0tsa_masters~0biosamples-covid19~0ebiweb_corporate~0omim~0lrg~0earlycause-molecular-sequences~0ipd-kir~0empiar~0rnacentral~0orcid_data_claims~0gpmdb~1lineage-covid19~0metagenomics~0pfam~0pride archive~1varsite~00Resource Reanalysis0.00.00.0064774830351634790.01.0falseEnvironmental interactions and epistasis are revealed in the proteomic responses to complex stimuliData from ProteomeXchange, PXD ID: PXD002371. File: WYPG37C_iTRAQ_11Step-MudPIT_21Jan12_PD1.4.msf.mgf. From ProteomeXchange: {{i}} ... In this study, we developed the concepts of environmental interactions and epistasis to explain the responses of the S. cerevisiae proteome to simultaneous environmental stimuli. We hypothesize that, as an abstraction, environmental stimuli can be treated as analogous to genetic elements. This would allow modeling of the effects of multiple stimuli using the concepts and tools developed for studying gene interactions. Mirroring gene interactions, our results show that environmental interactions play a critical role in determining the state of the proteome. We show that individual and complex environmental stimuli behave similarly to genetic elements in regulating the cellular responses to stimuli, including the phenomena of dominance and suppression ... {{/i}}2015-07-20GPM32310021827PXD002371PXD002371