{"database":"GPMDB","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":11,"searchCount":6},"additional":{"omics_type":["Other"],"submitter":["Haurogne K, et al."],"instrument_platform":["Instrument"],"disease":["Not Available"],"brenda_tissue":["Not available"],"species":["Mus_musculus_viruses, Mouse"],"submitter_mail":["jean-marie.bach@oniris-nantes.fr"],"publication":["26230114"],"model":["http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310024992","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310024997","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310024994","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310024993","http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310024995"],"submitter_affiliation":["INRA USC1383, IECM, Nantes, France, et al."],"cell_type":["CL:0000775 neutrophil"],"repository":["GPMDB"],"pubmed_abstract":["In humans, CXCR1 and CXCR2 are two homologous proteins that bind ELR+ chemokines. Both receptors play fundamental roles in neutrophil functions such as migration and reactive oxygen species production. Mouse Cxcr1 and Cxcr2 genes are located in an insulin-dependent diabetes genetic susceptibility locus. The non obese diabetic (NOD) mouse is a spontaneous well-described animal model for insulin-dependent type 1 diabetes. In this disease, insulin deficiency results from the destruction of insulin-producing beta cells by autoreactive T lymphocytes. This slow-progressing disease is dependent on both environmental and genetic factors. Here, we report descriptive data about the Cxcr1 gene in NOD mice. We demonstrate decreased expression of mRNA for Cxcr1 in neutrophils and CD4+ lymphocytes isolated from NOD mice compared to other strains, related to reduced NOD Cxcr1 gene promoter activity. Looking for Cxcr1 protein, we next analyze the membrane proteome of murine neutrophils by mass spectrometry. Although Cxcr2 protein is clearly found in murine neutrophils, we did not find evidence of Cxcr1 peptides using this method. Nevertheless, in view of recently-published experimental data obtained in NOD mice, we argue for possible Cxcr1 involvement in type 1 diabetes pathogenesis."],"pubmed_title":["Type 1 Diabetes Prone NOD Mice Have Diminished Cxcr1 mRNA Expression in Polymorphonuclear Neutrophils and CD4+ T Lymphocytes."],"pubmed_authors":["Haurogné Karine K,Pavlovic Marija M,Rogniaux Hélène H,Bach Jean-Marie JM,Lieubeau Blandine B,","Haurogné Karine K, Pavlovic Marija M, Rogniaux Hélène H, Bach Jean-Marie JM, Lieubeau Blandine B"],"name_synonyms":["Ketosis-Prone Diabetes Mellitus, 3.4.22.-, polynuclear neutrophilic leukocyte, Band Cell, T-cell surface antigen T4/Leu-3, Type I Diabetes, Laboratory, Mus domesticus, mini-ICE, Diabetes mellitus type 1 (disorder), CASP-14, Insulin Dependent Diabetes, DIABETES MELLITUS TYPE 01, House Mouse, Polymorphonuclear, Autoimmune Diabete, lymphocytes, Insulin dependent diabetes mellitus, L3T4, B37, CD181, C-C-CKR-1, neutrophilic leucocyte, House, Insulin-Dependent, neutrophil leukocyte, Ly-4, Juvenile onset diabetes mellitus, Mus musculus domesticus, LE Cell, not stated as uncontrolled, Type I, with unspecified complication, Sudden Onset, C-C, Autoimmune, Mice, Neutrophil Band Cells, Segmented/Neutrophils, D12S755E, Insulin-Dependent Diabetes Mellitus, Swiss, IL8RA, neutrophil leucocyte, Sudden-Onset Diabetes, messenger RNA, Swiss Mice, neutrophilic leukocyte, Brittle Diabetes Mellitus, template RNA, Neutrophils, Diabetes Mellitus, polynuclear neutrophilic leucocyte, polymorphonuclear leukocyte, Type 1 Diabetes, Lymphoid, LE, Diabetes, Neutrophil, Type 1 Diabetes Mellitus, IL8R1, Lymphocyte, Leukocyte, Juvenile Onset, HRS, Diabete, T-cell surface antigen T4|Leu-3, Leukocytes, mouse, Brittle, DRPLA, uncontrolled, Lymphoid Cells., DMI UNSPF UNCNTRLD, Ketosis Prone, neutrophils, Polymorphonuclear Leukocyte, Cell, Juvenile-Onset, NOD, Neutrophil Band Cell, neutrocyte, Diabetes mellitus type I, IL8RBA, LE Cells, Mus, T-cell differentiation antigen L3T4, Mini-ICE, Band Cells, CDw128a, INSDC_feature:mRNA, Lymphoid Cell, Mellitus, type I diabetes mellitus, Mus musculus, Sudden-Onset, Autoimmune Diabetes, IDDM, protein_coding_transcript, Caspase-14 subunit p10, IDDM - Insulin-dependent diabetes mellitus, mRNA, Diabetes mellitus type 1, mice, T-cell surface glycoprotein CD4, Swiss Mouse, Sudden-Onset Diabetes Mellitus, Diabetes mellitus type I [insulin dependent type] [IDDM] [juvenile type], Non-obese Diabetic, House Mice, CD4mut, Caspase-14 subunit p19, Juvenile Diabetes, MICE, CKR-1, NEUTSGNE, Type 1, Laboratory Mice, domesticus, Ketosis-Prone, CMKAR1, Cells, PMN, Polymorphonuclear Leukocytes, polymorphonuclear leucocyte, CD4, Mouse, poly, CD128, Laboratory Mouse, Juvenile-Onset Diabetes Mellitus, polymorphonuclear neutrophil, DMI UNSPF NT ST UNCNTRLD, Insulin Dependent"],"description_synonyms":["D12S755E, Mus musculus, 3.4.22.-, data, HRS, Caspase-14 subunit p10, Laboratory, IL8RA, Swiss, mice, Mus domesticus, Swiss Mouse, mouse, DRPLA, Non-obese Diabetic, House Mice, Swiss Mice, mini-ICE, Caspase-14 subunit p19, CASP-14, MICE, House Mouse, CKR-1, Laboratory Mice, domesticus, NOD, CD181, C-C-CKR-1, B37, IL8RBA, House, Mus, CMKAR1, Mini-ICE, CDw128a, Mus musculus domesticus, Mouse, C-C, CD128, Mice, Laboratory Mouse, IL8R1, Mus musculus."],"pubmed_title_synonyms":["Ketosis-Prone Diabetes Mellitus, 3.4.22.-, polynuclear neutrophilic leukocyte, Band Cell, T-cell surface antigen T4/Leu-3, Type I Diabetes, Laboratory, Mus domesticus, mini-ICE, Diabetes mellitus type 1 (disorder), CASP-14, Insulin Dependent Diabetes, DIABETES MELLITUS TYPE 01, House Mouse, Polymorphonuclear, Autoimmune Diabete, lymphocytes, Insulin dependent diabetes mellitus, L3T4, B37, CD181, C-C-CKR-1, neutrophilic leucocyte, House, Insulin-Dependent, neutrophil leukocyte, Ly-4, Juvenile onset diabetes mellitus, Mus musculus domesticus, LE Cell, not stated as uncontrolled, Type I, with unspecified complication, Sudden Onset, C-C, Autoimmune, Mice, Neutrophil Band Cells, Segmented/Neutrophils, D12S755E, Insulin-Dependent Diabetes Mellitus, Swiss, IL8RA, neutrophil leucocyte, Sudden-Onset Diabetes, messenger RNA, Swiss Mice, neutrophilic leukocyte, Brittle Diabetes Mellitus, template RNA, Neutrophils, Diabetes Mellitus, polynuclear neutrophilic leucocyte, polymorphonuclear leukocyte, Type 1 Diabetes, Lymphoid, LE, Diabetes, Neutrophil, Type 1 Diabetes Mellitus, IL8R1, Lymphocyte, Leukocyte, Juvenile Onset, HRS, Diabete, T-cell surface antigen T4|Leu-3, Leukocytes, mouse, Brittle, DRPLA, uncontrolled, Lymphoid Cells., DMI UNSPF UNCNTRLD, Ketosis Prone, neutrophils, Polymorphonuclear Leukocyte, Cell, Juvenile-Onset, NOD, Neutrophil Band Cell, neutrocyte, Diabetes mellitus type I, IL8RBA, LE Cells, Mus, T-cell differentiation antigen L3T4, Mini-ICE, Band Cells, CDw128a, INSDC_feature:mRNA, Lymphoid Cell, Mellitus, type I diabetes mellitus, Mus musculus, Sudden-Onset, Autoimmune Diabetes, IDDM, protein_coding_transcript, Caspase-14 subunit p10, IDDM - Insulin-dependent diabetes mellitus, mRNA, Diabetes mellitus type 1, mice, T-cell surface glycoprotein CD4, Swiss Mouse, Sudden-Onset Diabetes Mellitus, Diabetes mellitus type I [insulin dependent type] [IDDM] [juvenile type], Non-obese Diabetic, House Mice, CD4mut, Caspase-14 subunit p19, Juvenile Diabetes, MICE, CKR-1, NEUTSGNE, Type 1, Laboratory Mice, domesticus, Ketosis-Prone, CMKAR1, Cells, PMN, Polymorphonuclear Leukocytes, polymorphonuclear leucocyte, CD4, Mouse, poly, CD128, Laboratory Mouse, Juvenile-Onset Diabetes Mellitus, polymorphonuclear neutrophil, DMI UNSPF NT ST UNCNTRLD, Insulin Dependent"],"pubmed_abstract_synonyms":["Modb1, Soluble, Insulin B Chain, Materials, T-cell surface antigen T4/Leu-3, Laboratory, Mus domesticus, CASP-14, Insulin Dependent Diabetes, House Mouse, Adiposis, Polymorphonuclear, Obese, lymphocytes, Polypeptides, Insulin dependent diabetes mellitus, L3T4, unspecified, Tier, B37, neutrophilic leucocyte, Method, neutrophil leukocyte, Ly-4, Juvenile onset diabetes mellitus, LE Cell, not stated as uncontrolled, slow, Analysis, with unspecified complication, Sudden Onset, Leprb, animal, Autoimmune, present in fewer numbers in organism, DM - Diabetes mellitus, Neutrophil Band Cells, Mass Spectrum Analysis, human disease, Man (Taxonomy), Analyses, IL8RA, Sudden-Onset Diabetes, hypoplasia, Swiss Mice, proteins, Oxygen, Diabetes mellitus, decreased, Methodological Studies, polynuclear neutrophilic leucocyte, polymorphonuclear leukocyte, BJ ELR, \"mice C57BL/6xCBA/CaJ hybrid\" RELATED misspelling [], Homo sapiens disease, Lymphoid, Strains, house mouse, IL8R1, Type 1 Diabetes Mellitus, db, Regular, Juvenile Onset, HRS, DM, T-cell surface antigen T4|Leu-3, obese, animalia, Modern, mouse, Brittle, uncontrolled, membranous organ component, Procedure, Spectrum Analysis, results, mice C57BL/6xCBA/CaJ hybrid, Regular Insulin, OB-RGRP, Spectroscopy, NOD, Juvenile-Onset, Neutrophil Band Cell, neutrophil granulocyte, neutrocyte, organism, Diabetes mellitus type I, IL8RBA, LE Cells, Playthings and Play, Mini-ICE, CDw128a, Obese (finding), Obesity [Ambiguous], Diseases, Plaything, Intercrines, Genetic Materials, NOS, Lymphoid Cell, Soluble Insulin, Oxygen Radicals, Genetic Material, type I diabetes mellitus, Mus musculus, Sudden-Onset, Autoimmune Diabetes, IDDM, membrane of organ, whole organism, protein_coding_transcript, Caspase-14 subunit p10, IDDM - 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File: OB07268.mzml. Published as part of PLoS One. 2015 Jul 31;10(7):e0134365  . From the Abstract: {{i}} ... Here, we report descriptive data about the Cxcr1 gene in NOD mice ... {{/i}}","dates":{"submission":"2015-10-09"},"accession":"GPM32310024995","cross_references":{"pubmed":["26230114"],"Pride":["PXD003015"],"pride":[],"Pride Archive":["PXD003015"]}}