GPMDB00335OtherAlanko J, et al.InstrumentNot AvailableNot availableMus_musculus_viruses, Mousejoivaska@utu.fi26436690http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025112http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025113http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025157http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025110http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025154http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025111http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025155http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025152http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025153http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025150http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025151http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025118http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025119http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025116http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025117http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025114http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025158http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025159http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025115http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025123http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025124http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025121http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025122http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025120http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025129http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025127http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025128http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025125http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025126http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025134http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025135http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025132http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025133http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025130http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025131http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025138http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025139http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025136http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025137http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025101http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025145http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025146http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025102http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025143http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025144http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025100http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025141http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025142http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025140http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025109http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025107http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025108http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025105http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025149http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025106http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025147http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025103http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025148http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025104Turku Centre for Biotechnology, University of Turku, et al.Not availableGPMDBIntegrin-containing focal adhesions transmit extracellular signals across the plasma membrane to modulate cell adhesion, signalling and survival. Although integrins are known to undergo continuous endo/exocytic traffic, the potential impact of endocytic traffic on integrin-induced signals is unknown. Here, we demonstrate that integrin signalling is not restricted to cell-ECM adhesions and identify an endosomal signalling platform that supports integrin signalling away from the plasma membrane. We show that active focal adhesion kinase (FAK), an established marker of integrin-ECM downstream signalling, localizes with active integrins on endosomes. Integrin endocytosis positively regulates adhesion-induced FAK activation, which is early endosome antigen-1 and small GTPase Rab21 dependent. FAK binds directly to purified endosomes and becomes activated on them, suggesting a role for endocytosis in enhancing distinct integrin downstream signalling events. Finally, endosomal integrin signalling contributes to cancer-related processes such as anoikis resistance, anchorage independence and metastasis.Integrin endosomal signalling suppresses anoikis.Alanko Jonna J,Mai Anja A,Jacquemet Guillaume G,Schauer Kristine K,Kaukonen Riina R,Saari Markku M,Goud Bruno B,Ivaska Johanna J,Alanko Jonna J, Mai Anja A, Jacquemet Guillaume G, Schauer Kristine K, Kaukonen Riina R, Saari Markku M, Goud Bruno B, Ivaska Johanna Jbiological signaling, suspension induced apoptosis, detachment induced cell death., signalling process, signaling process, signalling, single organism signalingNat, NAT, AI662476, OCT, Focal Adhesion, data, Bru, PlexA2, biological signaling, inner endospore membrane., D17H6S113E, Raw, PLXN2, Focal Contacts, Cell-Matrix, Adherens Junctions, FSH, AA589422, Cell, Fsrg1, EMILIN4, cellular membrane, Experiment, RING3, AW457381, juxtamembrane, survival, uninterrupted, Endometriosis, Cell-Matrix Adherens Junction, AW228947, FSRG1, Del(8)44H, mKIAA4005, bacterial inner membrane, single organism cell adhesion, Endo, Focal Contact, CD105, Svc, Cell Matrix Adherens Junctions, D6S113E, Col4a-1, cell membrane, death rate, Focal, cell, Cell-Matrix Adherens Junctions, cell adhesion molecule activity, RNF3, Rnf3, Frg-1, 2810428A13Rik, Cell Adhesions, Ring3, Junction, Cell-Matrix Adherens, Junctions, Plaques, signalling, inner endospore membrane, extracellular, AI528660, Adhesions, plasma membrane lipid bilayer, GPIa*, signalling process, plasmalemma, time of survival, signaling process, Adhesion, ECM, Contact, Adherens Junction, Contacts, S-endoglin, cytoplasmic membrane, Adhesion Plaques, MMRN, E430016J11Rik, Plxn2, Adhesion Plaque, Fsrg-1, mKIAA0463, RWDD5, single organism signaling, Plaquebiological signaling, suspension induced apoptosis, detachment induced cell death., signalling process, signaling process, signalling, single organism signalingprojections, Focal Adhesion, biological signaling, Metastasis, lamellae, Endocytoses, Neoplasm Metastases, Adherens Junctions, nonselective vesicle endocytosis, process of organ, protrusion, lamella, endocytic import into cell, suspension induced apoptosis, uninterrupted, Roles, resistance, Antigen, Concepts, single organism cell adhesion, Endo, Kinase, mKIAA4203, Focal Contact, CD105, malignant tumour, adhesion plaque, hemi-adherens junction, Focal, Metastases., cell, Receptosome, Cell-Matrix Adherens Junctions, cell adhesion molecule activity, malignant neoplasia, ridges, Junctions, focal contact, inner endospore membrane, FAK1, AI528660, Adhesions, plasma membrane lipid bilayer, GPIa*, plasmalemma, time of survival, signaling process, papilla, Adhesion, ECM, Role Concepts, Adherens Junction, Contacts, S-endoglin, Adhesion Plaques, ATP Phosphotransferases, laminae, Adhesion Plaque, detachment induced cell death, ATP, single organism signaling, Plaque, Cancer, AI662476, Fadk, anatomical protrusion, pp125FAK, Malignant Neoplasm, plasma membrane invagination, Focal Contacts, anatomical process, Metastases, Cell-Matrix, lamina, flanges, 9630024B22, Cell, Phosphotransferases, p125FAK, Endosome, EMILIN4, Concept, FADK, vesicle endocytosis, cellular membrane, juxtamembrane, survival, Role Concept, FRNK, Endometriosis, Cell-Matrix Adherens Junction, shelf, Role, Neoplasm, bacterial inner membrane, Receptosomes, activation, flange, organ process, Transphosphorylases, Cell Matrix Adherens Junctions, cell membrane, death rate, distinct, Kinases, shelves, Cell Adhesions, Cancers, Junction, projection, Cell-Matrix Adherens, malignant tumor, ridge, Plaques, signalling, PPP1R71, extracellular, process, processes, signalling process, spine, Contact, FAK, processus, cytoplasmic membrane, MMRN, E430016J11Rik, RWDD53305http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32310025155dbgap_ncbi~0patentfamilies~0rfam~0merops~0complex-portal~0uniprot~0wormbaseparasite~0embl-covid19~0reactome~0emdb~0wgs_masters~0ebiweb_resources~0opentargets_genetics~0biomodels_all~0ipd-mhc~0ebiweb_teams~0taxonomy~0genome_assembly~0sc-experiments~0ebiweb_people~0enzymeportal_enzymes~0ipd-nhkir~0cellosaurus~0pdbe~0chebi~0patentproteins~0interpro7~0uniref~0chembl~0pdbekb~0gpcrdb~0hgnc~0sc-genes~0intact~0rhea~0ebiweb_training~0alphafold~0imgt-hla~0patentnucleotides~0ensemblroot~0eva_studies~0non-coding~0europepmc~0pubmed~1identifiers_registry~0pdbechem~0hpa-covid19~0eva-variants-covid19~0biosamples~0gwas_catalog~0biotools~0tls_masters~0mesh~0coding~0sra~0opentargets~0efo~0embl-pathogen~0project~0pride~1human_diseases~0geo_datasets~0embl~0treefam~0uniparc~0ols~0dgva~0intenz~0go~0tsa_masters~0biosamples-covid19~0ebiweb_corporate~0omim~0lrg~0earlycause-molecular-sequences~0ipd-kir~0empiar~0rnacentral~0orcid_data_claims~0gpmdb~2lineage-covid19~0metagenomics~0pfam~0pride archive~1varsite~00Resource Reanalysis0.00.00.0101789019123997540.01.0falseIntegrin endosomal signalling suppresses anoikis.Data from ProteomeXchange, PXD ID: PXD001870. Experiment: Plasma membrane fraction R2 raw, file: 150120_106.mzml. Published as part of Nat Cell Biol. 2015 Oct 5 . From the Abstract: {{i}} Integrin-containing focal adhesions transmit extracellular signals across the plasma membrane to modulate cell adhesion, signalling and survival. Although integrins are known to undergo continuous endo/exocytic traffic, the potential impact of endocytic traffic on integrin-induced signals is unknown. Here, we demonstrate that integrin signalling is not restricted to cell-ECM adhesions and identify an endosomal signalling platform that supports integrin signalling away from the plasma membrane ... {{/i}}2015-10-14GPM3231002515526436690PXD001870PXD001870