GPMDB00196OtherGroessl M, et al.InstrumentNot AvailableNot availableHomo_sapiens_viruses, Human_femalechristopher.gerner@univie.ac.at25238572University of Vienna, Faculty of Chemistry, Department of Analytical Chemistryhttp://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003645http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003646http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003643http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003644http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003649http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003647http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003648http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003641http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003642http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003640http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003656http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003657http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003654http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003655http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003658http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003659http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003652http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003653http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003650http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003651http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003700http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003667http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003701http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003668http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003665http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003666http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003704http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003705http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003702http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003669http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003703http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003660http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003663http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003664http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003661http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003662http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003709http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003706http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003711http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003678http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003679http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003712http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003676http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003710http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003677http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003715http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003716http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003713http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003714http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003670http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003671http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003674http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003675http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003672http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003673http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003719http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003717http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003718http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003722http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003689http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003723http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003720http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003687http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003721http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003726http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003727http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003724http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003725http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003681http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003682http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003680http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003685http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003686http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003683http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003684http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003728http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003729http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003612http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003733http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003734http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003613http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM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availableGPMDBBreast cancer is still the most common type of cancer in women; an important role in carcinogenesis is actually attributed to cancer-associated fibroblasts. In this study, we investigated whether it is possible to assess the functional state of cancer-associated fibroblasts through tumor tissue proteome profiling. Tissue proteomics was performed on tumor-central, tumor-near, and tumor-distant biopsy sections from breast adenocarcinoma patients, which allowed us to identify 2074 proteins. Data were interpreted referring to reference proteome profiles generated from primary human mammary fibroblasts comprising 4095 proteins. These cells were analyzed in quiescent cell state as well as after in vitro treatment with TGFβ or IL-1β, stimulating wound healing or inflammatory processes, respectively. Representative for cancer cells, we investigated the mammary carcinoma cell line ZR-75-1, identifying 5212 proteins. All mass analysis data have been made fully accessible via ProteomeXchange, DOI PXD001311 and PXD001323-8. Comparison of tissue proteomics data with all of those reference profiles revealed predominance of cancer cell-derived proteins within the tumor and fibroblast-derived proteins in the tumor-distant tissue sections. Remarkably, proteins characteristic for acute inflammation were hardly identified in the tissue samples. In contrast, several proteins found by us to be induced by TGFβ in mammary fibroblasts, including fibulin-5, SLC2A1, and MUC18, were positively identified in all tissue samples, with relatively higher abundance in tumor neighboring tissue sections. These findings indicate a predominance of cancer-associated fibroblasts with wound healing activities localized around tumors.Proteome profiling of breast cancer biopsies reveals a wound healing signature of cancer-associated fibroblasts.Groessl Michael M,Slany Astrid A,Bileck Andrea A,Gloessmann Kerstin K,Kreutz Dominique D,Jaeger Walter W,Pfeiler Georg G,Gerner Christopher C,Groessl Michael M, Slany Astrid A, Bileck Andrea A, Gloessmann Kerstin K, Kreutz Dominique D, Jaeger Walter W, Pfeiler Georg G, Gerner Christopher CHuman Mammary Neoplasm, Carcinoma, Carcinoma of breast NOS, Tumor-Associated., Healings, Breast Neoplasms, Wound, Neoplasms, Tumor-Associated, Tumor-Associated Fibroblast, Human Mammary Neoplasms, Fibroblasts, Tumor, Human, Tumor-Associated Fibroblasts, Cancer Associated Fibroblast, Mammary Carcinomas, Breast Tumor, BREAST NEOPL, Neoplasm, Human Mammary Carcinoma, Carcinoma of the Breast, Mammary carcinoma, Carcinomas, BC, Mammary Neoplasms, Breast Neoplasm, Human Mammary, Cancer Associated, Biopsies, NEOPL BREAST, Mammary Neoplasm, Carcinoma of breast NOS (disorder), Mammary Carcinoma, carcinoma OF breast, Wound Healings, Human Mammary Carcinomas, Cancer-Associated Fibroblast, Cancer of the Breast, CA - Carcinoma of breast, Breast Tumors, Breast Cancer, Carcinoma of breast (disorder), Cancer of Breast, Cancer Associated Fibroblasts, Tumor Associated Fibroblasts, Breast, Cancer-Associated, Healing, Proteomes, Fibroblast, Tumors, CancerCarcinoma of breast NOS, Tumorigeneses, PLXN5, Breast Neoplasms, Neoplasms, Tumor-Associated, Nl1, A4, Tumor-Associated Fibroblast, PLEXIN-B1, Human Mammary Neoplasms, Tumor, TGF-beta1, TYPE, TGFbeta, SeP, NEOPL, Human, DAGA4, CED, Tumor-Associated Fibroblasts, Cancer Associated Fibroblast, CEH, Roles, TGFbeta1, Breast Tumor, BREAST NEOPL, Girls, Gene Products, Concepts, NEPII, NL1, Carcinoma of the Breast, NL2, SEH, MAM, SCG3, malignant tumour, SEP, Tgfb-1, BC, Mammary Neoplasms, study, portion of tissue, Human Mammary, TGFB, Biopsies, Mammary Neoplasm, Carcinoma of breast NOS (disorder), Mammary Carcinoma, Tissue, Human Mammary Carcinomas, Cancer-Associated Fibroblast, malignant neoplasia, Oncogeneses, tumour, proteins, Cancer of the Breast, sEP, CA - Carcinoma of breast, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS), Clients, Role Concepts, SELP, Carcinoma of breast (disorder), Cancer Associated Fibroblasts, Tumor Associated Fibroblasts, Breast, Cancer-Associated, LAP, Neoplastic Growth, Tumors, Cancer, Gene., Human Mammary Neoplasm, Carcinoma, data, Malignant Neoplasm, Women's Group, Women Groups, Proteins, Mell1, Fibroblasts, Tumorigenesis, Woman, Client, Girl, tumours, LGMD2C, Concept, polypeptide, Experiment, Role Concept, Tgfb, MMEL2, Mammary Carcinomas, Protein, Neoplasm, Role, tissue portion, Human Mammary Carcinoma, simple tissue, Mammary carcinoma, Carcinomas, Breast Neoplasm, Cancer Associated, DMDA1, NEOPL BREAST, carcinoma OF breast, Women's Groups, Carcinogeneses, Cancers, DPD1, malignant tumor, Protein Gene Products, Gene Proteins, DMDA, Oncogenesis, Patient, Breast Tumors, Breast Cancer, SCARMD2, Cancer of Breast, Eph2, Proteomes, NEOPLASMS BENIGN, Neoplasia, NEP2, FibroblastHuman Mammary Neoplasm, Carcinoma, Carcinoma of breast NOS, Tumor-Associated., Healings, Breast Neoplasms, Wound, Neoplasms, Tumor-Associated, Tumor-Associated Fibroblast, Human Mammary Neoplasms, Fibroblasts, Tumor, Human, Tumor-Associated Fibroblasts, Cancer Associated Fibroblast, Mammary Carcinomas, Breast Tumor, BREAST NEOPL, Neoplasm, Human Mammary Carcinoma, Carcinoma of the Breast, Mammary carcinoma, Carcinomas, BC, Mammary Neoplasms, Breast Neoplasm, Human Mammary, Cancer Associated, Biopsies, NEOPL BREAST, Mammary Neoplasm, Carcinoma of breast NOS (disorder), Mammary Carcinoma, carcinoma OF breast, Wound Healings, Human Mammary Carcinomas, Cancer-Associated Fibroblast, Cancer of the Breast, CA - Carcinoma of breast, Breast Tumors, Breast Cancer, Carcinoma of breast (disorder), Cancer of Breast, Cancer Associated Fibroblasts, Tumor Associated Fibroblasts, Breast, Cancer-Associated, Healing, Proteomes, Fibroblast, Tumors, Cancerprojections, Inflammations, determination, Breast Neoplasms, Wound, C elegans, Tumor-Associated, A4, Tumor-Associated Fibroblast, Human Mammary Neoplasms, Tumor, Homo sapiense, Tumor-Associated Fibroblasts, IL-1, Homo sapien, Roles, Homo sapians, symptoms, Concepts, NEOPL., WMS, BC, treatment, Mammary Neoplasms, portion of tissue, Fbln1 protein, Homo sapients, inflammatory response, Biopsies, Tissue, Human Mammary Carcinomas, Cancer-Associated Fibroblast, breast epithelial cancer cell, breast carcinoma cell, Oncogeneses, proteins, Glut1, Glut-1, breast adenocarcinoma cell, fbl-1 protein, GLUT1, CA - Carcinoma of breast, GLUT, Homo sapience, Inflammation, EIG12, papilla, Role Concepts, disease management, AV025631, Carcinoma of breast (disorder), Cancer Associated Fibroblasts, Tumor Associated Fibroblasts, Healing, GPHYSD2, Home sapiens, SGS, Tumors, screening, Carcinoma, anatomical protrusion, lamina, mouse, flanges, Fibroblasts, Girl, tumours, ACMICD, Role Concept, Homo sapian, shelf, Role, tissue portion, IL1F2, concluding remarks, simple tissue, Mammary carcinoma, s-gicerin, Carcinomas, NEOPL BREAST, mammary cancer cell, shelves, carcinoma OF breast, conclusion, signs, MASS, Homo sapines, projection, ridge, human, summary, DMDA, Oncogenesis, Patient, s-endo, spine, Breast Tumors, PED, Proteomes, Fibroblast, Carcinoma of breast NOS, ZR-75-1, Tumorigeneses, human being, localised, Healings, lamellae, Neoplasms, FBN, Gene, interleukin-1 receptor ligand, process of organ, TYPE, NEOPL, DOI, Human, protrusion, DAGA4, DYT18, lamella, DYT17, Homo spaiens, Cancer Associated Fibroblast, conclusions, 1-gicerin, IL1-BETA, Breast Tumor, ECTOL1, BREAST NEOPL, Girls, Gene Products, Carcinoma of the Breast, MAM, SCG3, malignant tumour, mammary carcinoma cell, mammary adenocarcinoma cell, doi, study, Human Mammary, Mammary Neoplasm, cell, Carcinoma of breast NOS (disorder), Mammary Carcinoma, malignant neoplasia, inflammation, tumour, ridges, primary dermal fibroblast, man, Cancer of the Breast, OCTD, HTLVR, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS), MUC18, fibulin 1 protein, Clients, Homo sampiens, BM-90 protein, Muc18, mammary tumor cell, Breast, Cancer-Associated, laminae, Neoplastic Growth, Cancer, Human Mammary Neoplasm, data, findings, Malignant Neoplasm, mouse embryonic fibroblast, Women's Group, anatomical process, Women Groups, Proteins, GLUT-1, Tumorigenesis, DYT9, Woman, Client, Cell, LGMD2C, Concept, polypeptide, Mammary Carcinomas, Protein, chemical analysis, FBLN1 protein, Neoplasm, Human Mammary Carcinoma, MFS1, focal, Homo sapeins, CD149, flange, organ process, WMS2, CD146, Breast Neoplasm, Cancer Associated, DMDA1, Women's Groups, Wound Healings, Carcinogeneses, Humo sapiens, Cancers, malignant tumor, Protein Gene Products, Gene Proteins, process, processes, GLUT1DS, Homo spiens, breast tumor cell, "human" EXACT genbank_common_name [], Breast Cancer, SCARMD2, SSKS, processus, Cancer of Breast, assay, NEOPLASMS BENIGN, Neoplasia1906http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320003614dbgap_ncbi~0patentfamilies~0rfam~0merops~0complex-portal~0uniprot~0wormbaseparasite~0embl-covid19~0reactome~0emdb~0wgs_masters~0ebiweb_resources~0opentargets_genetics~0biomodels_all~0ipd-mhc~0ebiweb_teams~0taxonomy~0genome_assembly~0sc-experiments~0ebiweb_people~0enzymeportal_enzymes~0ipd-nhkir~0cellosaurus~0pdbe~0chebi~0patentproteins~0interpro7~0uniref~0chembl~0pdbekb~0gpcrdb~0hgnc~0sc-genes~0intact~0rhea~0ebiweb_training~0alphafold~0imgt-hla~0patentnucleotides~0ensemblroot~0eva_studies~0non-coding~0europepmc~0pubmed~1identifiers_registry~0pdbechem~0hpa-covid19~0eva-variants-covid19~0biosamples~0gwas_catalog~0biotools~0tls_masters~0mesh~0coding~0sra~0opentargets~0efo~0embl-pathogen~0project~0pride~1human_diseases~0geo_datasets~0embl~0treefam~0uniparc~0ols~0dgva~0intenz~0go~0tsa_masters~0biosamples-covid19~0ebiweb_corporate~0omim~0lrg~0earlycause-molecular-sequences~0ipd-kir~0empiar~0rnacentral~0orcid_data_claims~0gpmdb~3lineage-covid19~0metagenomics~0pfam~0pride archive~1varsite~00Resource Reanalysis0.00.00.0058605798889574340.01.0falseProteome profiling of breast cancer biopsies reveals a wound healing signature of cancer-associated fibroblasts.Data from ProteomeXchange, PXD ID: PXD001323. Experiment: hmf_cyt_TGFb_1, file: hmf_cyt_TGFb_1_2.mzml. Published as part of J Proteome Res. 2014 Sep 19. . From the Abstract: {{i}} Breast cancer is still the most common type of cancer in women; an important role in carcinogenesis is actually attributed to cancer-associated fibroblasts. In this study we investigated whether it is possible to assess the functional state of cancer-associated fibroblasts through tumor tissue proteome profiling. Tissue proteomics was performed on tumor-central, tumor-near and tumor-distant biopsy sections from breast adenocarcinoma patients, which allowed us to identify 2074 proteins ... {{/i}}2014-09-24GPM3232000361425238572PXD001323PXD001323