GPMDB00283OtherSchoelz C, et al.InstrumentNot AvailableNot availableHomo_sapiens_viruses, Humanchristian.scholz@cpr.ku.dkNot availablehttp://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007728http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007729http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007807http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007808http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007724http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007768http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007725http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007769http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007726http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007727http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007764http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007765http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007722http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007766http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007767http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007723http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007760http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007761http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007762http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007763http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007770http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007809http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007816http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007739http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007817http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007818http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007819http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007812http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007779http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007813http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007814http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007815http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007775http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007776http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007777http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007810http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007778http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007811http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007771http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007772http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007773http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007774http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007780http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007781http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007827http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007828http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007829http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007823http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007746http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007824http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007747http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007748http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007825http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007826http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007749http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007786http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007742http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007787http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007820http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007743http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007821http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007788http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007744http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007745http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007822http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007789http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007782http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007783http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007784http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007740http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007741http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007785http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007790http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007791http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007792http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007838http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007757http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007835http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007758http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007759http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007836http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007837http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007830http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007753http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007831http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007754http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007832http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007833http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007756http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007793http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007750http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007751http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320007752Novo Nordisk Foundation Center for Protein Research; University of CopenhagenNot availableGPMDBLysine Acetate, Lysine Hydrochloride, Acetate, Lysin, acetylation, 2, epsilon-diaminocaproic acid, Lysine, alpha, Acetylations., C6H14N2O2, 6-diaminohexanoic acid, L-Lysine, Enisyl, L Lysineprojections, N1-(4-((2R, Activity, Lysine Hydrochloride, Bufexamac-ratiopharm, Laboratory, lamellae, Droxaryl, Gene, SIR2L1, DOCS, process of organ, supernumerary, protrusion, lamella, Lysine Acetate, reduced, 3-dioxan-2-yl)phenyl)-N8-hydroxy-, Gene Products, pyridine-3-carboxamide, 5-diphenyl-2-oxazolyl)thio)methyl)-6-(4-(hydroxymethyl)phenyl)-1, 2, Lysine, tiny, Research Activity, Laboratory Research, Nicotinamide, Chromatins, octanediamide, L Lysine, Bufexamac ratiopharm, Priorities, treatment, chalcone synthetase activity, increased, AA673258, p Butoxyphenylacethydroxamic Acid, Research, 4-butoxy-N-hydroxy-, hypoplasia, epsilon-diaminocaproic acid, Acetylations, proteins, ridges, C6H14N2O2, NICOTINAMIDE, Bufal, Lysin, papilla, chromosome scaffold, disease management, Benzeneacetamide, Development and Research, Windol, Research Priority, associated, laminae, 6S)-4-(((4, small, rel-, flavanone synthase activity, data, anatomical protrusion, nicotinamide, malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing), anatomical process, CHS, acetylation, Proteins, lamina, Hdac5, flanges, Research Priorities, Jomax, Hd6, PPP1R90, 4R, polypeptide, Experiment, Priority, Acetate, Allergipuran, Protein, flavonone synthase activity, shelf, Research Activities, Chédiak-Higashi disease, chalcone synthase activity, L-Lysine, HD6, flange, organ process, Research and Development, Sfc6, Sir2alpha, duradermal, Chédiak-Higashi-Steinbrink syndrome, underdeveloped, increased number, shelves, Sir2, Paraderm, alpha, projection, mHDA2, ridge, Activities, Protein Gene Products, process, processes, present in greater numbers in organism, Gene Proteins, Sir2a, Chediak - Steinbrinck anomaly, spine, DEL, p-Butoxyphenylacethydroxamic Acid, Bufexamacratiopharm, CPBHM., processus, Chediak-Higashi syndrome, 6-diaminohexanoic acid, Enisyl, accessory, Bufederm, Parfenac, Malipuran280http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM323200078133dbgap_ncbi~0patentfamilies~0rfam~0merops~0complex-portal~0uniprot~0wormbaseparasite~0embl-covid19~0reactome~0emdb~0wgs_masters~0ebiweb_resources~0opentargets_genetics~0biomodels_all~0ipd-mhc~0ebiweb_teams~0taxonomy~0genome_assembly~0sc-experiments~0ebiweb_people~0enzymeportal_enzymes~0ipd-nhkir~0cellosaurus~0pdbe~0chebi~0patentproteins~0interpro7~0uniref~0chembl~0pdbekb~0gpcrdb~0hgnc~0sc-genes~0intact~0rhea~0ebiweb_training~0alphafold~0imgt-hla~0patentnucleotides~0ensemblroot~0eva_studies~0non-coding~0europepmc~0identifiers_registry~0pdbechem~0hpa-covid19~0eva-variants-covid19~0biosamples~0gwas_catalog~0biotools~0tls_masters~0mesh~0coding~0sra~0opentargets~0efo~0embl-pathogen~0project~0pride~1human_diseases~0geo_datasets~0embl~0treefam~0uniparc~0ols~0dgva~0intenz~0go~0tsa_masters~0biosamples-covid19~0ebiweb_corporate~0omim~0lrg~0earlycause-molecular-sequences~0ipd-kir~0empiar~0rnacentral~0orcid_data_claims~0gpmdb~1lineage-covid19~0metagenomics~0pfam~0pride archive~1varsite~00Resource Reanalysis0.00.00.008636644046884640.01.0falseUnraveling Lysine Deacetylase Inhibitor Specificities for Endogenous Acetylation SitesData from ProteomeXchange: PXD ID: PXD001377. Experiment: Bufexamacproteome_hs_LH, file: 20120521_QE3_LC2_CHS_SA_Bufexamacproteome_03.mzml. From ProteomeXchange: {{i}} Lysine deacetylases (KDACs) are important regulators of biological processes. KDAC inhibitors (KDACIs) are important tools for basic research and attractive therapeutic candidates, yet their effects on in-vivo acetylation sites are poorly known. Here we obtained acetylation signatures for 19 different KDACIs that cover all known deacetylases. Most KDACIs targeting non-sirtuin deacetylases increased acetylation of a small, but specific, subset of the acetylome, and included sites on histone and other chromatin-associated proteins. Using a combination of genetic deletion and inhibitor treatment we found that the sirtuin inhibitor nicotinamide increased acetylation via SIRT1 inhibition, whereas tubacin and bufexamac affected cytoplasmic proteins through inhibition of HDAC6 ... {{/i}}2015-02-23GPM32320007813PXD001377PXD001377