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Geisel School of Medicine at Dartmouth"],"cell_type":["Not available"],"repository":["GPMDB"],"pubmed_abstract":["Complex phosphorylation-dependent signaling networks underlie the coordination of cellular growth and division. In the fission yeast Schizosaccharomyces pombe, the Dual specificity tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family protein kinase Pom1 regulates cell cycle progression through the mitotic inducer Cdr2 and controls cell polarity through unknown targets. Here, we sought to determine the phosphorylation targets of Pom1 kinase activity by SILAC-based phosphoproteomics. We defined a set of high-confidence Pom1 targets that were enriched for cytoskeletal and cell growth functions. Cdr2 was the only cell cycle target of Pom1 kinase activity that we identified in cells. Mutation of Pom1-dependent phosphorylation sites in the C terminus of Cdr2 inhibited mitotic entry but did not impair Cdr2 localization. In addition, we found that Pom1 phosphorylated multiple substrates that function in polarized cell growth, including Tea4, Mod5, Pal1, the Rho GAP Rga7, and the Arf GEF Syt22. Purified Pom1 phosphorylated these cell polarity targets in vitro, confirming that they are direct substrates of Pom1 kinase activity and likely contribute to regulation of polarized growth by Pom1. Our study demonstrates that Pom1 acts in a linear pathway to control cell cycle progression while regulating a complex network of cell growth targets."],"pubmed_title":["Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1."],"pubmed_authors":["Kettenbach Arminja N AN,Deng Lin L,Wu Youjun Y,Baldissard Suzanne S,Adamo Mark E ME,Gerber Scott A SA,Moseley James B JB,","Kettenbach Arminja N AN, Deng Lin L, Wu Youjun Y, Baldissard Suzanne S, Adamo Mark E ME, Gerber Scott A SA, Moseley James B JB"],"name_synonyms":["dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A protein, dual specificity tyrosine-phosphorylation regulated kinase, MNBH protein, dual specificity protein kinase Dyrk, Fission, metabolism resulting in cell growth, number, mouse, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a protein, Schizosaccharomyces pombe, minibrain kinase, Schizosaccharomyces malidevorans, S pombe, presence, rat., Mirk protein, DYRK4A protein, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1c, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b, Dyrk1a protein, cell expansion, count in organism, rat, DYRK1A protein, Mirk protein kinase, Fission Yeast, count, Dyrk1c protein, DYRK2 protein, non-developmental cell growth, minibrain homolog protein, dual-specificity tyrosine-phosphorylation regulated kinase 1B, Schizosaccharomyce, dual-specificity tyrosine-phosphorylation regulated kinase 1A, fission yeast, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B, Dyrk protein, Yeasts, Dyrk2 protein, Yeast, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4, Schizosaccharomyces pombeP, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2, Dyrk4 protein, growth of cell, non-developmental growth of a unicellular organism, pombe, S, metabolic process resulting in cell growth, mnbk protein, DYRK4B protein, S pombes, dual-specificity tyrosine-phosphorylation regulated kinase 4A, human, Schizosaccharomyces, dual-specificity tyrosine-phosphorylation regulated kinase 4B, Fission Yeasts, Schizosaccharomyces pombes, Dyrk1b protein, DYRK1B protein, pombes, DYRK1 protein, cellular growth, Mnbh protein, dual-specificity tyrosine-phosphorylation regulated kinase 2, dual-specificity tyrosine-phosphorylation regulated kinase 3, quantitative, dual-specificity tyrosine-phosphorylation regulated kinase 4, presence or absence in organism"],"description_synonyms":["MTS1, IPP2A2, Huntington disease gene regulatory region-binding protein 1, Lfc, mol, IPT, INK4, Acute renal failure, Arhd, GTPase-activating protein, Renal Insufficiency, Pctr1, GDS, GEFH1, ras p21 protein activator, phosphorylation, PHAPII, cell growth in one dimension, 5730420M11Rik, Mutations, 2310075G14Rik, AA408978, template-activating factor I, GEF, Cycle, establishment and maintenance of position, HDBP1, PKWS, Pal1, ARF-INK4a, Arf, establishment and maintenance of substrate location, cell morphogenesis by unidimensional growth, ARF, Yo, phosphokinase activity, p16(INK4a), Cell Division Cycles, Cycles, Acute Kidney Insufficiency, Acute Renal Insufficiency, Set, SET, opsin-2, GNRP, growth of cell, TAF-I, RasGAP, cell, Sets (Psychology), non-developmental growth of a unicellular organism, phosphatase 2A inhibitor I2PP2A, AI314635, cell elongation, Cell Division Cycle, cell-division cycle, cell growth along one axis, Kidney Insufficiency, MTS-1, metabolic process resulting in cell growth, Cell Division, CDR62, LFP40, CDR2, AKI, OPN2, AI314189, IGAAD, Acute Renal Injury, polar cell growth, 2PP2A, Ink4a|Arf, RhoHP1, Acute kidney failure, Cell Cycles, guanyl-nucleotide release factor activity, cellular growth, CMM2, p19ARF, CM-AVM, P14, P16, Gfi-1, P19, P16-INK4A, establishment and maintenance of substance location, data, AW495828, TP16, P16INK4, polarized cell growth, metabolism resulting in cell growth, MLM, Renal Failure, Phosphorylations, StF-IT-1, HSC0013, p16, function, RASGAP, RASA, p19-lt-ARF-gt-, Cell, p16INK4a, Division Cycles, AA617262, cell expansion, single organism localization, AV099619, I-2PP2A, P14ARF, non-developmental cell growth, I2PP2A, RhoM, RHOM, establishment and maintenance of localization, RASA1, MOD5, GAP, RHOHP1, p120GAP, p120RASGAP, GEF-H1, GDP-dissociation stimulator activity, P16INK4A, Si-1-2, Si-1-2-19, HLA-DR-associated protein II, Division Cycle, Pal-1, AI326383, Kidney Failure, P40, CDK4I, Lbcl1, RGD1310578, HDBP-1, single-organism localization, inhibitor of granzyme A-activated DNase, RHO, Rho, CMAVM, mKIAA0651, INK4a-ARF, guanyl-nucleotide releasing factor., GLUT4 enhancer factor, 2610030F17Rik, Acute, TAF-IBETA, localisation, Ras p21 protein activator, P19ARF, ARHD, AA407739, INK4A, establishment and maintenance of cellular component location, CDKN2"],"pubmed_title_synonyms":["Yeasts, Yeast, Transphosphorylases, Schizosaccharomyces pombeP, growth of cell, Kinases, non-developmental growth of a unicellular organism, Fission, metabolism resulting in cell growth, pombe, ATP., number, S, metabolic process resulting in cell growth, Schizosaccharomyces pombe, S pombes, Schizosaccharomyces malidevorans, S pombe, presence, Phosphotransferases, Schizosaccharomyces, cell expansion, count in organism, Fission Yeasts, Fission Yeast, Schizosaccharomyces pombes, count, non-developmental cell growth, pombes, cellular growth, Kinase, quantitative, ATP Phosphotransferases, Schizosaccharomyce, fission yeast, presence or absence in organism"],"pubmed_abstract_synonyms":["Extended Families, Networks, MTS1, para Tyrosine, IPP2A2, Huntington disease gene regulatory region-binding protein 1, Extended, Kinship, Lfc, IPT, Fission, Polarities, Renal Insufficiency, Extended Family, Pctr1, Schizosaccharomyces pombe, GEFH1, establishment and/or maintenance of cell polarization, ras p21 protein activator, phosphorylation, 5730420M11Rik, Mutations, AA408978, Mp86, Fission Yeast, HP86, AA959943, Life Cycle, PKWS, ARF-INK4a, Arf, Kinase, establishment and maintenance of substrate location, ARF, Schizosaccharomyce, phosphokinase activity, p16(INK4a), fission yeast, Family Life Cycle, Cell Division Cycles, Set, SET, opsin-2, Kinship Network, reference sample, TAF-I, non-developmental growth of a unicellular organism, Sets (Psychology), 2-amino-3-(4-hydroxyphenyl)propanoic acid, 3-(p-Hydroxyphenyl)alanine, phosphatase 2A inhibitor I2PP2A, AI314635, S, cell growth along one axis, Kidney Insufficiency, MTS-1, metabolic process resulting in cell growth, proteins, cell polarity, CDR2, Acts, AI314189, IGAAD, Acute Renal Injury, Acute kidney failure, signaling process, Tyr, Cell Cycles, cellular growth, CM-AVM, P14, P16, Gfi-1, Family Life Cycles, ATP Phosphotransferases, P19, ENSMUSG00000074897, P16-INK4A, ATP, single organism signaling, Acta-2, establishment and maintenance of substance location, polarized cell growth, metabolism resulting in cell growth, MLM, 2-Amino-3-(p-hydroxyphenyl)propionic acid, StF-IT-1, HSC0013, Actsk-1, p16, para-Tyrosine, S pombe, RASA, Division Cycles, Tyrosine, single organism localization, AV099619, non-developmental cell growth, RhoM, RHOM, GAP, metabolism resulting in cell growth., Filiation, RHOHP1, p120RASGAP, GEF-H1, D16Ertd493e, MNB, Si-1-2, Yeasts, Yeast, Transphosphorylases, mmb, Si-1-2-19, HLA-DR-associated protein II, Reconstituted Family, Division Cycle, growth pattern, AI326383, P40, non-developmental growth, L-isomer, RGD1310578, inhibitor of granzyme A-activated DNase, RHO, Rho, Polarity, L isomer, Life Cycles, GLUT4 enhancer factor, Reconstituted, TAF-IBETA, Ras p21 protein activator, pombes, ARHD, L-Tyrosine, INK4A, MRD7, establishment and maintenance of cellular component location, CDKN2, guanyl-nucleotide releasing factor, biological signaling, Family Member, INK4, Gm10783, Acute renal failure, Arhd, GTPase-activating protein, Network, GDS, Schizosaccharomyces malidevorans, PHAPII, cell growth in one dimension, 2310075G14Rik, establishment and/or maintenance of cell polarity, template-activating factor I, GEF, Cycle, establishment and maintenance of position, HDBP1, Pal1, cell morphogenesis by unidimensional growth, Yo, Cycles, Acute Kidney Insufficiency, Acute Renal Insufficiency, study, Schizosaccharomyces pombeP, GNRP, growth of cell, Research, RasGAP, pombe, cell elongation, Cell Division Cycle, cell-division cycle, Cell Division, CDR62, LFP40, Schizosaccharomyces, AKI, OPN2, polar cell growth, Schizosaccharomyces pombes, 2PP2A, Ink4a|Arf, L Tyrosine, RhoHP1, guanyl-nucleotide release factor activity, CMM2, p19ARF, Tyrosin, Kinship Networks, Family, Controlled, MNBH, DYRK1, Controlling, AW495828, TP16, P16INK4, Family Research, Dyrk, Renal Failure, Phosphorylations, Reconstituted Families, function, RASGAP, p19-lt-ARF-gt-, Phosphotransferases, Cell, p16INK4a, D16Ertd272e, Family Members, AA617262, polypeptide, cell expansion, PSK47, tirosina, Stepfamily, I-2PP2A, P14ARF, DYRK, I2PP2A, establishment and maintenance of localization, RASA1, MOD5, p120GAP, GDP-dissociation stimulator activity, P16INK4A, 2310043O08Rik, Pal-1, Kidney Failure, Kinases, CDK4I, Lbcl1, Cell Polarities, HDBP-1, single-organism localization, C9H11NO3, S pombes, CMAVM, mKIAA0651, signalling, INK4a-ARF, Mnbh, Fission Yeasts, 2610030F17Rik, Acute, localisation, signalling process, Families, P19ARF, regulation, AA407739, Relatives, 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File: o53292.mzml. Published as part of Mol Cell Proteomics. 2015 Feb 26  . From the Abstract: {{i}} ... Here, we sought to determine the phosphorylation targets of Pom1 kinase activity by SILAC-based phosphoproteomics. We defined a set of high-confidence Pom1 targets that were enriched for cytoskeletal and cell growth functions. Cdr2 was the only cell cycle target of Pom1 kinase activity that we identified in cells. Mutation of Pom1-dependent phosphorylation sites in the C-terminus of Cdr2 inhibited mitotic entry but did not impair Cdr2 localization. In addition, we found that Pom1 phosphorylated multiple substrates that function in polarized cell growth, including Tea4, Mod5, Pal1, the Rho GAP Rga7, and the Arf GEF Syt22 ... {{/i}}","dates":{"submission":"2015-03-09"},"accession":"GPM32320013881","cross_references":{"pubmed":["25720772"],"Pride":["PXD001649"],"pride":[],"Pride Archive":["PXD001649"]}}