GPMDB00203OtherFischer T, et al.InstrumentNot AvailableNot availableS_pombetamas.fischer@bzh.uni-heidelberg.deNot availablehttp://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320015030http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320015018http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320015007http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320015029http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320015017http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320015028http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320015009http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320015019http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320015008http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320015010http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320015021http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320015020http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320015012http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320015011http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320015022http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320015025http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320015014http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320015024http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320015013http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320015016http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320015027http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320015026http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320015015BZH Heidelberg UniversityNot availableGPMDBYeasts, Yeast, Mtl1-Red1 core complex, Schizosaccharomyces pombeP, Fission Yeasts, Fission Yeast, Schizosaccharomyces pombes, exosome., Fission, pombe, pombes, extracellular vesicular exosome, S, Schizosaccharomyces pombe, Schizosaccharomyce, S pombes, Schizosaccharomyces malidevorans, S pombe, fission yeast, Schizosaccharomycesprojections, multicellular organismal catabolic process, single-organism catabolic process, CPD photolyase activity, PhrB photolyase activity, lamellae, frc, CSMF, fierce, photoreactivating enzyme activity, Schizosaccharomyces malidevorans, organ process., pigmented epithelium, process of organ, deoxyribodipyrimidine photolyase activity, stratum pigmentosum retinae, protrusion, lamella, Trf4 complex, Roles, Trf4p-Air2p-Mtr4p polyadenylation complex, Concepts, extracellular vesicular exosome, stratum pigmentosa retinae, outer pigmented layer of retina, epithelium, fission yeast, Schizosaccharomyces pombeP, deoxyribocyclobutadipyrimidine pyrimidine-lyase activity, Trf4 poly(A) polymerase complex, AI573420, catabolism, pigmented retina, messenger RNA, XTLL, TRAMP4 complex, ridges, DNA cyclobutane dipyrimidine photolyase activity, template RNA, pigment epithelium of retina, NOR-1, cryptic, Mtl1, papilla, Role Concepts, pigmented retina epithelium, b2b970Clo, laminae, tailless, PRE, data, NOR1, Nor1, anatomical protrusion, CHN, degradation, anatomical process, deoxyribonucleic cyclobutane dipyrimidine photolyase activity, TRAMP5 complex, lamina, flanges, AV265756, pigmented retinal epithelium, Concept, CFC1B, Mtll, stratum pigmentosum (retina), Role Concept, retinal pigment, deoxyribonucleic photolyase activity, shelf, Role, dipyrimidine photolyase (photosensitive), INSDC_feature:mRNA, retinal pigment layer, flange, Mtl1-Red1 core complex, HTX2, RPE, breakdown, protein_coding_transcript, mRNA, MINOR, photolyase activity, retinal pigmented epithelium, shelves, CRYPTIC, TLL, retinal pigment epithelium, projection, ridge, p. pigmentosa retinae, Tlx, process, processes, phr A photolyase activity, DNA-photoreactivating enzyme, spine, DTGA2, processus, TEC, deoxyribonucleate pyrimidine dimer lyase (photosensitive), Minor, exosome200http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM323200150133dbgap_ncbi~0patentfamilies~0rfam~0merops~0complex-portal~0uniprot~0wormbaseparasite~0embl-covid19~0reactome~0emdb~0wgs_masters~0ebiweb_resources~0opentargets_genetics~0biomodels_all~0ipd-mhc~0ebiweb_teams~0taxonomy~0genome_assembly~0sc-experiments~0ebiweb_people~0enzymeportal_enzymes~0ipd-nhkir~0cellosaurus~0pdbe~0chebi~0patentproteins~0interpro7~0uniref~0chembl~0pdbekb~0gpcrdb~0hgnc~0sc-genes~0intact~0rhea~0ebiweb_training~0alphafold~0imgt-hla~0patentnucleotides~0ensemblroot~0eva_studies~0non-coding~0europepmc~0identifiers_registry~0pdbechem~0hpa-covid19~0eva-variants-covid19~0biosamples~0gwas_catalog~0biotools~0tls_masters~0mesh~0coding~0sra~0opentargets~0efo~0embl-pathogen~0project~0pride~1human_diseases~0geo_datasets~0embl~0treefam~0uniparc~0ols~0dgva~0intenz~0go~0tsa_masters~0biosamples-covid19~0ebiweb_corporate~0omim~0lrg~0earlycause-molecular-sequences~0ipd-kir~0empiar~0rnacentral~0orcid_data_claims~0gpmdb~1lineage-covid19~0metagenomics~0pfam~0pride archive~1varsite~00Resource Reanalysis0.00.00.0061690314620604570.01.0falseThe fission yeast MTREC complex targets CUTs and unspliced mRNAs to the nuclear exosomeData from ProteomeXchange, PXD ID: PXD001908. File: Mtl1.Iss10-6F.mzml. From ProteomeXchange: {{i}} Cryptic unstable transcripts (CUTs) are rapidly degraded by the nuclear exosome. However, the mechanism by which they are recognized and targeted to the exosome is not fully understood. Here, we report that the MTREC complex, which has recently been shown to promote degradation of meiotic mRNAs and regulatory ncRNAs, is also the major nuclear exosome targeting complex for CUTs and unspliced pre-mRNAs in Schizosaccharomyces pombe. MTREC complex specifically binds to CUTs, meiotic mRNAs and unspliced pre-mRNA transcripts and targets these RNAs for degradation by the nuclear exosome, while the TRAMP complex has only a minor role in this process ... {{/i}}2015-04-29GPM32320015013PXD001908PXD001908