GPMDB00235OtherCehofski LJ, et al.InstrumentNot AvailableNot availablePigL.cehofski@rn.dk26086079http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017450http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017428http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017429http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017426http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017427http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017449http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017420http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017442http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017443http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017421http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017440http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017462http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017463http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017441http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017446http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017424http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017447http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017425http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017422http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017444http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017423http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017445http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017460http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017461http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017439http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017417http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017418http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017437http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017459http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017416http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017438http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017419http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017431http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017453http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017454http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017432http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017451http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017452http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017430http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017435http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017457http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017436http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017458http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017433http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017455http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017434http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017456Aalborg University Hospital, Aalborg, Denmark;Not availableGPMDBBranch retinal vein occlusion (BRVO) is a common retinal vascular disease, but global protein changes following the condition remain largely unelucidated. To bring new insights into pathological processes and identify potential therapeutic targets, large-scale retinal protein changes following BRVO were studied by combining a porcine model of experimental BRVO with proteomic analysis by label-free liquid chromatography mass spectrometry. Among a total set of 1974 proteins, 52 significantly upregulated proteins and 10 significantly downregulated proteins were identified in retinas with BRVO after 15 days. Significantly upregulated proteins were involved in signaling pathways of focal adhesion via integrin and blood coagulation. Proteins involved in focal adhesion signaling included collagen α-2 chain, laminin subunit β-2, laminin subunit γ-1, lipocalin-7, nidogen-2, osteopontin, integrin-β, α-actinin-1, isoform 2 of α-actinin-1, talin-2 and filamin C. The identified proteins indicate that BRVO was associated with extracellular matrix remodeling processes. The present study identified focal adhesion signaling and ECM remodeling as important biological mechanisms to evaluate in the search for signaling pathways that promote neovascularisation and macular edema following BRVO.Proteins involved in focal adhesion signaling pathways are differentially regulated in experimental branch retinal vein occlusion.Cehofski Lasse Jørgensen LJ,Kruse Anders A,Kjærgaard Benedict B,Stensballe Allan A,Honoré Bent B,Vorum Henrik H,Cehofski Lasse Jørgensen LJ, Kruse Anders A, Kjærgaard Benedict B, Stensballe Allan A, Honoré Bent B, Vorum Henrik HFocal Adhesion, Retinal Vein., biological signaling, experimental, Focal Contacts, Proteins, Retinal vein occlusion, Cell-Matrix, Gene, Adherens Junctions, of retinal vein, Retinal Vein Occlusions, Retinal Vein Thrombosis, Thromboses, polypeptide, Retinal Vein Thromboses, Occlusions, Cell-Matrix Adherens Junction, Thrombosis, Protein, Gene Products, Vein Occlusion, Focal Contact, Retinal, Occlusion, adhesion plaque, hemi-adherens junction, Cell Matrix Adherens Junctions, methods, lateral shoot, Focal, Cell-Matrix Adherens Junctions, experimental section, Retinal Vein, proteins, Vein Thrombosis, Junction, Cell-Matrix Adherens, Vein Thromboses, Junctions, Plaques, focal contact, signalling, experimental procedures, Protein Gene Products, Gene Proteins, Adhesions, signalling process, Retinal Vein Occlusion, signaling process, Adhesion, Contact, Vein Occlusions, Adherens Junction, Contacts, Adhesion Plaques, Adhesion Plaque, axillary shoot, single organism signaling, Plaqueprojections, big, scale tissue, visual_system, photoreceptor, compound eye, regio orbitalis, experimental, lamellae, AP-1, peltate hair, Retinal vein occlusion, Vitamin A, adult compound eye, Spectrum Analyses, Retinal Vein Occlusions, process of organ, protrusion, Thromboses, lamella, "Komplexauge", large, Retinal Vein Thromboses, Occlusions, camera-type eye plus associated structures, "Facettenauge", eye, Mass, Vein Occlusion, globe, Analysis, MBNL, vascular diseases, Mass Spectroscopy, Occlusion, Mass Spectrum Analysis, light-detecting organ, Orbital region, Junc, methods, lateral shoot, Analyses, eyes, Retinal Vein, experimental section, plant peltate hair, visual system, Retinene, proteins, ridges, Vein Thromboses, free, 11 cis Retinal, "zusammengesetztes Auge", Retinal Vein Occlusion, papilla, great, Vein Occlusions, c-Jun, laminae, axillary shoot, eye globe, data, anatomical protrusion, Vitamin A Aldehyde, anatomical process, c-jun, lamina, Liquid Chromatography, flanges, bulbus oculi, vertebrate eye, of retinal vein, Spectrum Analysis, visual apparatus, Retinal Vein Thrombosis, Spectroscopy, polypeptide, Eyes, Axerophthal, Thrombosis, shelf, proteomic analysis, 11-cis-Retinal, "internal elastic lamina" EXACT [], scales, flange, Mass Spectrum Analyses, eyeball, Retinal, organ process, Mass Spectrum, scale, EXP40, EXP42, shelves, Orbital part of face, expanded, Spectrometry, Vein Thrombosis, projection, ridge, experimental procedures, AP1, process, processes, enlarged, EXP35, orbital region, orbital part of face, spine, Aldehyde, Mass., processus, EXPFocal Adhesion, Retinal Vein., biological signaling, experimental, Focal Contacts, Proteins, Retinal vein occlusion, Cell-Matrix, Gene, Adherens Junctions, of retinal vein, Retinal Vein Occlusions, Retinal Vein Thrombosis, Thromboses, polypeptide, Retinal Vein Thromboses, Occlusions, Cell-Matrix Adherens Junction, Thrombosis, Protein, Gene Products, Vein Occlusion, Focal Contact, Retinal, Occlusion, adhesion plaque, hemi-adherens junction, Cell Matrix Adherens Junctions, methods, lateral shoot, Focal, Cell-Matrix Adherens Junctions, experimental section, Retinal Vein, proteins, Vein Thrombosis, Junction, Cell-Matrix Adherens, Vein Thromboses, Junctions, Plaques, focal contact, signalling, experimental procedures, Protein Gene Products, Gene Proteins, Adhesions, signalling process, Retinal Vein Occlusion, signaling process, Adhesion, Contact, Vein Occlusions, Adherens Junction, Contacts, Adhesion Plaques, Adhesion Plaque, axillary shoot, single organism signaling, Plaqueprojections, Focal Adhesion, scale tissue, IPP2A2, Collagens, Retina, Blood, Nid protein, Retinal vein occlusion, Adherens Junctions, Eu Actinin, Sialoprotein 1, Thromboses, 5730420M11Rik, rat, Occlusions, Vein Occlusion, Analysis, Focal Contact, vascular diseases, Zyderm, Extracellular Matrices, Sialoprotein I, Laminin M, Occlusion, Mass Spectrum Analysis, Macular Dystrophy, adhesion plaque, Set, SET, hemi-adherens junction, Inner layer of eyeball, Analyses, TAF-I, Focal, Retinal Vein, Sets (Psychology), Cell-Matrix Adherens Junctions, plant peltate hair, phosphatase 2A inhibitor I2PP2A, Microfibril Collagen Hemostat, tunica interna of eyeball, Actinins, proteins, present in organism, Blood Clotting, free, beta-Actinin, Edema, IGAAD, Adhesions, ch, Protein p235, GPIa*, Retinal Vein Occlusion, papilla, signaling process, Collagen Fleece, nidogen 1, Adhesion, Adherens Junction, Contacts, Collagen, associated, Adhesion Plaques, Adhesion Plaque, single organism signaling, Plaque, anatomical protrusion, Coagulation, enactin protein, Vitamin A Aldehyde, Focal Contacts, lamina, Liquid Chromatography, Cell-Matrix, mouse, flanges, StF-IT-1, Laminin, Band 2 Protein, inner layer of eyeball, Dominant Cystoid, Spectrum Analysis, Spectroscopy, Irvine-Gass Syndrome, Cell-Matrix Adherens Junction, shelf, Retinas, M Chain, blood clotting, Retinal, Cystoid Macular, HLA-DR-associated protein II, Bone Sialoprotein 1, shelves, Merosin, Bone Sialoprotein I, expanded, Spectrometry, inhibitor of granzyme A-activated DNase, Macular, nidogen-1, Junction, projection, ridge, Cell-Matrix Adherens, human, Plaques, experimental procedures, TAF-IBETA, enlarged, spine, Aldehyde, Laminin M Chain, Collagen Felt, Platelet, nidogen protein, Macular Edema, Bone, big, entactin protein, biological signaling, experimental, lamellae, Band 2, Clotting, peltate hair, Vitamin A, alpha-Collagen, Matrix, Gene, Irvine Gass Syndrome., entactin, Spectrum Analyses, Retinal Vein Occlusions, Matrices, process of organ, PHAPII, protrusion, lamella, alpha-, large, Retinal Vein Thromboses, Microfibril, template-activating factor I, Dermodress, Collastat, Mass, Gene Products, nidogen 1 protein, Mass Spectroscopy, alpha Actinin, Netzhaut, Irvine-Gass, Chain, study, methods, lateral shoot, retinas, retina of camera-type eye, experimental section, Avitene, Retinene, ridges, Vein Thromboses, Junctions, alpha Collagen, focal contact, Postoperative, 11 cis Retinal, NID1 protein, 2PP2A, great, Extracellular, ECM, Syndrome, Vein Occlusions, Glycoprotein GP-2, laminae, axillary shoot, Collagenfleece, Glycoprotein GP 2, anatomical process, Proteins, of retinal vein, Cystoid Macular Edema, Cystoid Macular Dystrophy, EMILIN4, Retinal Vein Thrombosis, polypeptide, Axerophthal, I-2PP2A, Thrombosis, Protein, proteomic analysis, I2PP2A, Blood Clottings, Collagen Hemostat, 11-cis-Retinal, "internal elastic lamina" EXACT [], Cystoid, scales, Nid1 protein, flange, Mass Spectrum Analyses, organ process, Pangen, Tunica interna of eyeball, Mass Spectrum, beta Actinin, Cell Matrix Adherens Junctions, scale, Avicon, Vein Thrombosis, signalling, Secreted Phosphoprotein 1, Protein Gene Products, Eu-Actinin, process, processes, Gene Proteins, 2610030F17Rik, Lipocalin, Central Retinal Edema, signalling process, Contact, processus, MMRN, AA407739, entactin-1 protein, alpha-Actinin, Uropontin, proteinaceous extracellular matrix, Platelet Protein p2352305http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM32320017441dbgap_ncbi~0patentfamilies~0rfam~0merops~0complex-portal~0uniprot~0wormbaseparasite~0embl-covid19~0reactome~0emdb~0wgs_masters~0ebiweb_resources~0opentargets_genetics~0biomodels_all~0ipd-mhc~0ebiweb_teams~0taxonomy~0genome_assembly~0sc-experiments~0ebiweb_people~0enzymeportal_enzymes~0ipd-nhkir~0cellosaurus~0pdbe~0chebi~0patentproteins~0interpro7~0uniref~0chembl~0pdbekb~0gpcrdb~0hgnc~0sc-genes~0intact~0rhea~0ebiweb_training~0alphafold~0imgt-hla~0patentnucleotides~0ensemblroot~0eva_studies~0non-coding~0europepmc~0pubmed~1identifiers_registry~0pdbechem~0hpa-covid19~0eva-variants-covid19~0biosamples~0gwas_catalog~0biotools~0tls_masters~0mesh~0coding~0sra~0opentargets~0efo~0embl-pathogen~0project~0pride~1human_diseases~0geo_datasets~0embl~0treefam~0uniparc~0ols~0dgva~0intenz~0go~0tsa_masters~0biosamples-covid19~0ebiweb_corporate~0omim~0lrg~0earlycause-molecular-sequences~0ipd-kir~0empiar~0rnacentral~0orcid_data_claims~0gpmdb~2lineage-covid19~0metagenomics~0pfam~0pride archive~1varsite~00Resource Reanalysis0.00.00.0070943861813695250.01.0falseProteins involved in focal adhesion signaling pathways are differentially regulated in experimental branch retinal vein occlusion.Data from ProteomeXchange, PXD ID: PXD001800. File: 6H_02.mzml. Published as part of Exp Eye Res. 2015 Jun 15;138:87-95 . From the Abstract: {{i}} Branch retinal vein occlusion (BRVO) is a common retinal vascular disease, but global protein changes following the condition remain largely unelucidated. To bring new insights into pathological processes and identify potential therapeutic targets, large-scale retinal protein changes following BRVO were studied by combining a porcine model of experimental BRVO with proteomic analysis by label-free liquid chromatography mass spectrometry ... {{/i}}2015-07-31GPM3232001744126086079PXD001800PXD001800