GPMDB00283OtherWeinert BT, et al.InstrumentNot AvailableNot availableMus_musculus_viruses, Mousebriantate.weinert@cpr.ku.dkNot availableThe NNF Center for Protein Research, Faculty of Health Sciences University of Copenhagen, et 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availableGPMDBacetylation, SIR2L3, Acetylations, assay, Acetylations., determination, chemical analysisbiochemical pathways, the brain, Brain, 3.4.22.-, Metabolic Process, Herz, Entire brain, Entire heart, Laboratory, Biocatalysts, Processes, Mus domesticus, SIR2L3, Metabolic Concepts, number, Adipose Tissue - Brown (MMHCC), branchial heart, adult heart, mini-ICE, CASP-14, Spectrum Analyses, Metabolic Processes, Encephalons, presence, House Mouse, jecur, circulatory vessel, Readability, House, Metabolism, central nervous system, Mass, Diets, Concepts, Mus musculus domesticus, synganglion, Low, Analysis, Metabolism Concept, multilocular adipose tissue, Phenomenon, Metabolism Phenomena, Mice, Mass Spectroscopy, Mass Spectrum Analysis, portion of tissue, Nervous System, deacetylation., me75, enzymes, CNS, Brains, Analyses, catabolism, Swiss, heart or heart like organ, Tissue, Acetylations, iecur, Metabolic Concept, brown fat, Swiss Mice, metabolic process resulting in cell growth, cardiac structure, suprasegmental levels of nervous system, "mouse" EXACT common_name [], D17Mit170, T1, Fast, "Mus muscaris" RELATED misnomer [], cardiac pump, biotransformation, "mice C57BL/6xCBA/CaJ hybrid" RELATED misspelling [], brown adipose tissue, house mouse, Catabolism, incorporation, vertebrate heart, dorsal tube, data, suprasegmental structures, cou, degradation, Process, Entire liver, metabolism resulting in cell growth, acetylation, Proteins, mouse, enzyme activity, Mitochondrial Protein, Hearts, Tl3, Tl2, Spectrum Analysis, encephalon, brain structure, mice C57BL/6xCBA/CaJ hybrid, Mus muscaris, Concept, Metabolic Phenomena, Spectroscopy, Metabolism Concepts, count in organism, chambered heart, Brown Adipose Tissue, Lr, count, Mus, Protein, Mini-ICE, heart, Phenomena, tissue portion, simple tissue, cardium, metabolism, textus adiposus fuscus, Mass Spectrum Analyses, Metabolic Phenomenon, Mass Spectrum, Mus musculus, mobilization, multicellular organism metabolic process, Mitochondrial, biodegradation, Caspase-14 subunit p10, Metabolic, mice, Dietary, Encephalon, Swiss Mouse, Spectrometry, House Mice, Caspase-14 subunit p19, Understanding, MICE, turnover, Laboratory Mice, domesticus, "house mouse" EXACT genbank_common_name [], Livers, single-organism metabolic process, Herz@de, adipocytus multigutturalis, Bra, Mouse, BAT, quantitative, Laboratory Mouse, Anabolism, presence or absence in organism280http://gpmdb.thegpm.org/~/dblist_gpmnum/gpmnum=GPM323200179743dbgap_ncbi~0patentfamilies~0rfam~0merops~0complex-portal~0uniprot~0wormbaseparasite~0embl-covid19~0reactome~0emdb~0wgs_masters~0ebiweb_resources~0opentargets_genetics~0biomodels_all~0ipd-mhc~0ebiweb_teams~0taxonomy~0genome_assembly~0sc-experiments~0ebiweb_people~0enzymeportal_enzymes~0ipd-nhkir~0cellosaurus~0pdbe~0chebi~0patentproteins~0interpro7~0uniref~0chembl~0pdbekb~0gpcrdb~0hgnc~0sc-genes~0intact~0rhea~0ebiweb_training~0alphafold~0imgt-hla~0patentnucleotides~0ensemblroot~0eva_studies~0non-coding~0europepmc~0identifiers_registry~0pdbechem~0hpa-covid19~0eva-variants-covid19~0biosamples~0gwas_catalog~0biotools~0tls_masters~0mesh~0coding~0sra~0opentargets~0efo~0embl-pathogen~0project~0pride~1human_diseases~0geo_datasets~0embl~0treefam~0uniparc~0ols~0dgva~0intenz~0go~0tsa_masters~0biosamples-covid19~0ebiweb_corporate~0omim~0lrg~0earlycause-molecular-sequences~0ipd-kir~0empiar~0rnacentral~0orcid_data_claims~0gpmdb~1lineage-covid19~0metagenomics~0pfam~0pride archive~1varsite~00Resource Reanalysis0.00.00.008636644046884640.01.0falseAnalysis of acetylation stoichiometry suggests that SIRT3 repairs nonenzymatic acetylation lesions.Data from ProteomeXchange, PXD ID: PXD000885. File: 20110706_VELOS1_BTW_SA_C2T1_F02.mzml. Published as part of . From the Abstract: {{i}} Acetylation is frequently detected on mitochondrial enzymes, and the sirtuin deacetylase SIRT3 is thought to regulate metabolism by deacetylating mitochondrial proteins. However, the stoichiometry of acetylation has not been studied and is important for understanding whether SIRT3 regulates or suppresses acetylation. Using quantitative mass spectrometry, we measured acetylation stoichiometry in mouse liver tissue and found that SIRT3 suppressed acetylation to a very low stoichiometry at its target sites. By examining acetylation changes in the liver, heart, brain, and brown adipose tissue of fasted mice, we found that SIRT3-targeted sites were mostly unaffected by fasting, a dietary manipulation that is thought to regulate metabolism through SIRT3-dependent deacetylation. {{/i}}2015-09-16GPM32320017974PXD000885PXD000885