{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Wu Zhong"],"species":["Homo Sapiens"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0002079000"],"submitter_email":["zhongwu@bmi.ac.cn"],"submitter_affiliation":["National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology."],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"pubmed_abstract":["The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality. However, the molecular characteristics and pathological features underlying COVID-19 pneumonia remain largely unknown. To characterize molecular mechanisms underlying COVID-19 pathogenesis in the lung tissue using a proteomic approach, fresh lung tissues were obtained from newly deceased patients with COVID-19 pneumonia. After virus inactivation, a quantitative proteomic approach combined with bioinformatics analysis was used to detect proteomic changes in the SARS-CoV-2-infected lung tissues. We identified significant differentially expressed proteins involved in a variety of fundamental biological processes including cellular metabolism, blood coagulation, immune response, angiogenesis, and cell microenvironment regulation. Several inflammatory factors were upregulated, which was possibly caused by the activation of NF-κB signaling. Extensive dysregulation of the lung proteome in response to SARS-CoV-2 infection was discovered. Our results systematically outlined the molecular pathological features in terms of the lung response to SARS-CoV-2 infection, and provided the scientific basis for the therapeutic target that is urgently needed to control the COVID-19 pandemic."],"pubmed_title":["Pathological features of COVID-19-associated lung injury: a preliminary proteomics report based on clinical samples."],"pubmed_authors":["Leng Ling L, Cao Ruiyuan R, Ma Jie J, Mou Danlei D, Zhu Yunping Y, Li Wei W, Lv Luye L, Gao Dunqin D, Zhang Shikun S, Gong Feng F, Zhao Lei L, Qiu Bintao B, Xiang Haiping H, Hu Zhongjie Z, Feng Yingmei Y, Dai Yan Y, Zhao Jiang J, Wu Zhihong Z, Li Hongjun H, Zhong Wu W"],"additional_accession":[]},"is_claimable":false,"name":"Proteomics Characterization of COVID-19 lung tissues","description":"The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality. However, the molecular characteristics and pathological features underlying COVID-19 pneumonia remain largely unknown. To characterize molecular mechanisms underlying COVID-19 pathogenesis in the lung tissue using a proteomic approach, fresh lung tissues were obtained from newly deceased patients with COVID-19 pneumonia. After virus inactivation, a quantitative proteomic approach combined with bioinformatics analysis was used to detect proteomic changes in the SARS-CoV-2 infected lung tissues. We identified significant differentially expressed proteins involved in a variety of fundamental biological processes including cellular metabolism, blood coagulation, immune response, angiogenesis, and cell microenvironment regulation. Several inflammatory factors were up-regulated, which was possibly caused by the activation of NF-κB signaling. Extensive dysregulation of the lung proteome in response to SARS-CoV-2 infection was discovered. Our results systematically outlined the molecular pathological features in terms of the lung response to SARS-CoV-2 infection, and provided the scientific basis for the therapeutic target that is urgently needed to control the COVID-19 pandemic.","dates":{"publication":"Thu Mar 19 00:00:00 GMT 2020"},"accession":"PXD018094","cross_references":{"TAXONOMY":["9606"],"pubmed":["33060566"]}}