iProXProteomicsWu ZhongHomo Sapienshttp://www.iprox.org/page/project.html?id=IPX0002279000zhongwu@bmi.ac.cnNational Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology.iProXPathological features of COVID-19-associated liver injury-a preliminary proteomics report based on clinical samples.Leng Ling L, Cao Ruiyuan R, Ma Jie J, Lv Luye L, Li Wei W, Zhu Yunping Y, Wu Zhihong Z, Wang Manli M, Zhou Yiwu Y, Zhong Wu WfalseIntegrated Proteomics Characterization of SARS-CoV-2 Associated Liver InjuryThe high incidence of liver injury in patients with COVID-19 and the need for long-term medication for recovery make it imperative to study the infectivity and pathogenicity of SARS-CoV-2 in the liver. Here, we have identified significant proteomic changes for the first time in the liver of patients with COVID-19 using a quantitative proteomics approach. We detected differential expression levels of several proteins that mediate characteristic cellular host responses elicited by SARS-CoV-2 infection. These findings reveal important molecular mechanisms that may play a key role in the pathogenesis of COVID-19 associated liver diseases and provide a scientific basis for medical intervention strategy and drug target selection.Tue Jun 23 00:00:00 BST 2020PXD019968960633419962