{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Juntao Yang"],"species":["Homo Sapiens"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0004918000"],"submitter_email":["yangjt@pumc.edu.cn"],"submitter_affiliation":["Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"pubmed_abstract":["Lactate is closely related to various cellular processes, such as angiogenesis, responses to hypoxia, and macrophage polarization, while regulating natural immune signaling pathways and promoting neurogenesis and cognitive function. Lysine lactylation (Kla) is a novel posttranslational modification, the examination of which may lead to new understanding of the nonmetabolic functions of lactate and the various physiological and pathological processes in which lactate is involved, such as infection, tumorigenesis and tumor development. Using liquid chromatography-tandem mass spectrometry (LC-MS/MS), researchers have identified lactylation in human gastric cancer cells and some other species, but no research on lactylation in human lungs has been reported. In this study, we performed global profiling of lactylation in human lungs under normal physiological conditions, and 724 Kla sites in 451 proteins were identified. After comparing the identified proteins with those reported in human lactylation datasets, 141 proteins that undergo lactylation were identified for the first time in this study. Our work expands the database on human lactylation and helps advance the study on lactylation function and regulation under physiological and pathological conditions."],"pubmed_title":["Global profiling of lysine lactylation in human lungs."],"pubmed_authors":["Yang Ye-Hong YH, Wang Qiao-Chu QC, Kong Jie J, Yang Jun-Tao JT, Liu Jiang-Feng JF"],"pubmed_abstract_synonyms":["liquid chromatography tandem mass spectroscopy, Cognitive Function, Post Translational Amino Acid Modification, L-Lactic Acid, posttranslational modification, single-organism developmental process, Activity, Lysine Hydrochloride, Laboratory, postnatal development, 2-Hydroxy-, Pb, Infestations and Infections, D-Lactic Acid, growth and development, protein, Tumor, Protein Processing, Stomach Neoplasms, malignant fundus of stomach neoplasm, Long Term, NEOPL STOMACH, Oxygen Deficiencies, Readability, Lysine Acetate, malignant neoplasm of fundus of stomach, Familial Diffuse, pulmones, 2, lungs pair, Research Activity, tumor of the stomach, gastric fundus cancer, gastric neoplasm, Laboratory Research, Effect, Formal Social Controls, L Lysine, Priorities, Post-Translational Protein, average, posttranslational amino acid modification, LCMSMS, Man (Taxonomy), K, Post-Translational, Personnel, 2-Hydroxypropionic Acid, epsilon-diaminocaproic acid, Oncogeneses, proteins, Posttranslational Protein Processing, L Lactic Acid, Social, malignant neoplasm of body of stomach, Oxygen, Cognitions, LYS, Functions, malignant tumour of fundus of stomach, Lysin, Malignancies, Infections and Infestations, Research Priority, Cancer of the Stomach, Long-Term Effects, Ca body - stomach, single organism signaling, Sarcolactic Acid, Tumors, LC-MS2, Post-Translational Modification, anatomical protrusion, plomo, GASC, Modern, Modifications, Blei, LC-MS/MS, Longterm Effect, Research Priorities, plomb, 82Pb, neoplasm of the stomach, Insight, STOMACH NEOPL, Post Translational Modifications, Benign, lysine, Gastric Neoplasms, D Lactic Acid, Stomach Cancer, Research and Development, Clinical Investigator, PTM, gastric tumour, macrophage polarization, stomach neoplasm (disease), Processing, 2-Hydroxypropanoic Acid, Neurogeneses, Control, Hypoxemia, Benign Neoplasms, Pathologic, Infection and Infestation, Researcher, b-lactate, alpha, Controls, human, Malignant Neoplasms, Activities, Stomach, Amino Acid Modification, Oncogenesis, spine, post-translational modification, liquid chromatography-tandem mass spectroscopy, neoplasm of stomach, tumor of stomach, Posttranslational Modifications, Anoxemia, other neoplasm, neural cell differentiation, Regulation, Posttranslational Modification, ca greater curvature of stomach, Regulations, Ammonium, Tumorigeneses, human being, Post-Translational Protein Modifications, Effects, Processes, Neoplasms, 2 Hydroxypropionic Acid, Deficiencies, Benign Neoplasm, Gene, Angiogeneses, beta-lactate, Malignant, Propanoic Acid, LC-MS-MS, protrusion, Posttranslational, Human, Oxygen Deficiency, (2S)-, Ca fundus - stomach, Homo sapiens, stomach neoplasm, LC-MSMS, Post Translational Modification, Gene Products, Survey, Post-Translational Modifications, malignant tumor of fundus of stomach, Lysine, Hypoxia, Man, Post Translational, stomach tumor, Modification, study, Clinical, MeCH(OH)CO2 anion, Malignancy, Research, Longterm, Investigators, stomach tumour, Clinical Investigators, Ammonium Lactate, posttranslational protein modification, Gastric Cancer, Long-Term, clinical infection, man, Cognitive Functions, Protein Modifications, Post-Translational Amino Acid Modification, Neoplasias, Infestation and Infection, gastric cancer, Posttranslational Amino Acid Modification, Cancer of Stomach, lead, blood vessel formation from pre-existing blood vessels, Posttranslational Protein, Long-Term Effect, species, Development and Research, 2-hydroxypropionate, Cancer, tumour of stomach, Lactate, 2 Hydroxypropanoic Acid, Stomach Neoplasm, Malignant Neoplasm, Social Controls., Formal Social Control, Investigator, Proteins, Post-Translational Protein Modification, ion(1-), function, lungs, Tumorigenesis, fundus of stomach cancer, cancer of fundus of stomach, Gastric cancer, gastric tumor, Cell, cognitive function, Stomach Cancers, development, Anoxia, Insights, LC/MS/MS, Priority, native protein, Social Control, Acetate, Protein, Long Term Effects, Research Activities, Infection, Neoplasm, Pathological, Protein Modification, L-Lysine, Gastric, Data Base, Survey Personnel, Post Translational Protein Processing, plumbum, Function, Carcinogeneses, postnatal growth, Gastric Cancers, Pathological Processes, Cancers, Understanding, set of lungs, Cognitive, Gastric Neoplasm, post-translational amino acid modification, Longterm Effects, Protein Gene Products, Gene Proteins, Post Translational Protein Modification, Deficiency, (2R)-, signalling process, NEOPL GASTRIC, 2-hydroxypropanoic acid, Modern Man, Post-Translational Protein Processing, liquid chromatography tandem mass spectrometry, Researchers, Lungs, regulation, 6-diaminohexanoic acid, growth, tumour of the stomach, Enisyl, Neoplasia, GASTRIC NEOPL"],"name_synonyms":["human being, Man (Taxonomy), pulmo, Lysine Hydrochloride, K, Modern, lung parenchyma, epsilon-diaminocaproic acid, alpha, man, human, Human, parenchyma of lung., Lysine Acetate, LYS, Homo sapiens, pulmonary, Acetate, Lysin, Modern Man, lysine, lung, 2, Lungs, Lysine, 6-diaminohexanoic acid, L-Lysine, neoplasm, Enisyl, Man, neoplasms, L Lysine"],"pubmed_title_synonyms":["human being, Man (Taxonomy), Lysine Hydrochloride, K, Modern, epsilon-diaminocaproic acid, alpha, set of lungs, lungs, man, human, Human, Lysine Acetate, LYS, Homo sapiens, Acetate, Lysin, Modern Man, lysine, pulmones., 2, lungs pair, Lungs, Lysine, 6-diaminohexanoic acid, L-Lysine, Enisyl, Man, L Lysine"],"description_synonyms":["liquid chromatography tandem mass spectroscopy, LC-MS2, LCMSMS, human being, Man (Taxonomy), pulmo, Modern, average., LC-MS/MS, lung parenchyma, man, human, LC-MS-MS, Human, LC/MS/MS, Homo sapiens, pulmonary, liquid chromatography-tandem mass spectroscopy, parenchyma of lung, Modern Man, LC-MSMS, lung, liquid chromatography tandem mass spectrometry, Lungs, neoplasm, Man, neoplasms"],"additional_accession":[]},"is_claimable":false,"name":"Global Profiling of the Lysine Lactylation in Human Lung","description":"LC-MS/MS for global profiling of lactylation in human lung under normal physiological conditions","dates":{"publication":"Thu Aug 25 00:00:00 GMT+01:00 2022"},"accession":"PXD036307","cross_references":{"TAXONOMY":["9606"],"pubmed":["37170646"]}}