{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Xiaohong Fang"],"species":["Homo Sapiens"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0006422000"],"submitter_email":["xfang@iccas.ac.cn"],"submitter_affiliation":["Institute of Hangzhou Medicine, Chinese Academy of Sciences"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"pubmed_abstract":["Kinase inhibitors against Cyclin Dependent Kinase 4 and 6 (CDK4/6i) are promising cancer therapeutic drugs. However, their effects are limited by primary or acquired resistance in virtually all tumor types. Here, we demonstrate that Leucine Rich Pentatricopeptide Repeat Containing (LRPPRC) controls CDK4/6i response in lung cancer by forming a feedback loop with CDK6. LRPPRC binds to CDK6-mRNA, increasing the stability and expression of CDK6. CDK6 and its downstream E2F Transcription Factor 1 (E2F1), bind to the LRPPRC promoter and elevate LRPPRC transcription. The activation of the LRPPRC-CDK6 loop facilitates cell cycle G1/S transition, oxidative phosphorylation, and cancer stem cell generation. Gossypol acetate (GAA), a gynecological medicine that has been repurposed as a degrader of LRPPRC, enhances the CDK4/6i sensitivity in vitro and in vivo. Our study reveals a mechanism responsible for CDK4/6i resistance and provides an enlightening approach to investigating the combinations of CDK4/6 and LRPPRC inhibitors in cancer therapy."],"pubmed_title":["The RNA-binding protein LRPPRC promotes resistance to CDK4/6 inhibition in lung cancer."],"pubmed_authors":["Zhou Wei W, Wang Wenxi W, Liang Yuxin Y, Jiang Ruibin R, Qiu Fensheng F, Shao Xiying X, Liu Yang Y, Fang Le L, Ni Maowei M, Yu Chenhuan C, Zhao Yue Y, Huang Weijia W, Li Jiong J, Donovan Michael J MJ, Wang Lina L, Ni Juan J, Wang Dachi D, Fu Ting T, Feng Jianguo J, Wang Xiaojia X, Tan Weihong W, Fang Xiaohong X"],"additional_accession":[]},"is_claimable":false,"name":"Proteomics comparison of protein changes in H1299 cell before and after resistance to cdk4/6 inhibitors","description":"This is the raw proteomics data of H1299 cell before and after resistance to cdk4/6 inhibitors","dates":{"publication":"Mon May 15 00:00:00 BST 2023"},"accession":"PXD042216","cross_references":{"TAXONOMY":["9606"],"pubmed":["37452037"]}}