{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Minfeng Shu"],"species":["Homo Sapiens"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0006644000"],"submitter_email":["minfeng_shu@fudan.edu.cn"],"submitter_affiliation":["Fudan University"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"pubmed_abstract":["Oncolytic virotherapy holds promise for cancer treatment, but the factors determining its oncolytic activity remain unclear. Neutrophil extracellular traps (NETs) are associated with cancer progression, yet their formation mechanism and role in oncolytic virotherapy remain elusive. In this study, we demonstrate that, in glioma, upregulation of IGF2BP3 enhances the expression of E3 ubiquitin protein ligase MIB1, promoting FTO degradation via the ubiquitin-proteasome pathway. This results in increased m6A-mediated CSF3 release and NET formation. Oncolytic herpes simplex virus (oHSV) stimulates IGF2BP3-induced NET formation in malignant glioma. In glioma models in female mice, a BET inhibitor enhances the oncolytic activity of oHSV by impeding IGF2BP3-induced NETosis, reinforcing virus replication through BRD4 recruitment with the CDK9/RPB-1 complex to HSV gene promoters. Our findings unveil the regulation of m6A-mediated NET formation, highlight oncolytic virus-induced NETosis as a critical checkpoint hindering oncolytic potential, and propose targeting NETosis as a strategy to overcome resistance in oncolytic virotherapy."],"pubmed_title":["Overcoming therapeutic resistance in oncolytic herpes virotherapy by targeting IGF2BP3-induced NETosis in malignant glioma."],"pubmed_authors":["Dai Weiwei W, Tian Ruotong R, Yu Liubing L, Bian Shasha S, Chen Yuling Y, Yin Bowen B, Luan Yuxuan Y, Chen Siqi S, Fan Zhuoyang Z, Yan Rucheng R, Pan Xin X, Hou Yingyong Y, Li Rong R, Chen Juxiang J, Shu Minfeng M"],"additional_accession":[]},"is_claimable":false,"name":"Look for FTO ubiquitin proteins","description":"To unravel the mechanism proteasomal degradation of FTO","dates":{"publication":"Wed Jun 28 00:00:00 BST 2023"},"accession":"PXD043362","cross_references":{"TAXONOMY":["9606"],"pubmed":["38167409"]}}