{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Haibo Qiu"],"species":["Mus Musculus"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0006661000"],"submitter_email":["haiboq2000@163.com"],"submitter_affiliation":["Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"additional_accession":[]},"is_claimable":false,"name":"The role of endothelial cell-derived extracellular vesicles in acute respiratory distress syndrome","description":"Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common life-threatening critical syndrome with no effective pharmacotherapy. Extracellular vesicles (EVs) are considered as a new way of long-distance communication between cells. Our previous research using an ex vivo perfused human ALI model suggested that endothelial cell-derived EVs (EC-EVs) mediate the development of ALI/ARDS. However, how EC-EVs aggravate lung injury remains largely unknown. Here we demonstrated that EC-EVs released under inflammatory stimulation can lead to ALI, and the proteomic analysis was performed on EC-EVs to explore the mechanism.","dates":{"publication":"Mon Jul 03 00:00:00 GMT+01:00 2023"},"accession":"PXD043470","cross_references":{"TAXONOMY":["10090"]}}