iProXProteomicsHaibo QiuMus Musculushttp://www.iprox.org/page/project.html?id=IPX0006661000haiboq2000@163.comJiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, ChinaiProXfalseThe role of endothelial cell-derived extracellular vesicles in acute respiratory distress syndromeAcute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common life-threatening critical syndrome with no effective pharmacotherapy. Extracellular vesicles (EVs) are considered as a new way of long-distance communication between cells. Our previous research using an ex vivo perfused human ALI model suggested that endothelial cell-derived EVs (EC-EVs) mediate the development of ALI/ARDS. However, how EC-EVs aggravate lung injury remains largely unknown. Here we demonstrated that EC-EVs released under inflammatory stimulation can lead to ALI, and the proteomic analysis was performed on EC-EVs to explore the mechanism.Mon Jul 03 00:00:00 GMT+01:00 2023PXD04347010090