{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Jianye Dai"],"species":["Rattus Norvegicus"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0007588000"],"submitter_email":["daijy@lzu.edu.cn"],"submitter_affiliation":["Lanzhou University"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"additional_accession":[]},"is_claimable":false,"name":"Activity-based protein profiling reveals Hydroxysafflor yellow A binds to malate dehydrogenase 1 against myocardial ischemia reperfusion injury by maintaining mitochondrial functional homeostasis","description":"Hydroxysafflor yellow A (HSYA), a natural product derived from Carthamus tinctorius L., has been approved for the treatment of cardiovascular and cerebrovascular diseases and emerged as an effective therapeutic drug on myocardial ischemia reperfusion (MI/R) injury via mechanisms which are poorly understood. We employed Reductive dimethyl labeling with tandem orthogonal proteolysis-activity-based protein profiling (rdTOP-ABPP) method to reveal the direct binding proteins and site in mitochondrion.","dates":{"publication":"Sat Nov 18 00:00:00 GMT 2023"},"accession":"PXD047081","cross_references":{"TAXONOMY":["10116"]}}