{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Xiaoshuai Zhang"],"species":["Periplaneta Americana"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0007719000"],"submitter_email":["20210029@m.scnu.edu.cn"],"submitter_affiliation":["Institute of Insect Science and Technology &amp; School of Life Sciences, South China Normal University"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"pubmed_abstract":["Appendage regeneration relies on the formation of blastema, a heterogeneous cellular structure formed at the injury site. However, little is known about the early injury-activated signaling pathways that trigger blastema formation during appendage regeneration. Here, we provide compelling evidence that the extracellular signal-regulated kinase (ERK)-activated casein kinase 2 (CK-2), which has not been previously implicated in appendage regeneration, triggers blastema formation during leg regeneration in the American cockroach, <i>Periplaneta americana</i>. After amputation, CK-2 undergoes rapid activation through ERK-induced phosphorylation within blastema cells. RNAi knockdown of <i>CK-2</i> severely impairs blastema formation by repressing cell proliferation through down-regulating mitosis-related genes. Evolutionarily, the regenerative role of CK-2 is conserved in zebrafish caudal fin regeneration via promoting blastema cell proliferation. Together, we find and demonstrate that the ERK-activated CK-2 triggers blastema formation in both cockroach and zebrafish, helping explore initiation factors during appendage regeneration."],"pubmed_title":["ERK-activated CK-2 triggers blastema formation during appendage regeneration."],"pubmed_authors":["Zhang Xiao-Shuai XS, Wei Lin L, Zhang Wei W, Zhang Fei-Xue FX, Li Lin L, Li Liang L, Wen Yejie Y, Zhang Jia-Hui JH, Liu Suning S, Yuan Dongwei D, Liu Yanmei Y, Ren Chonghua C, Li Sheng S"],"additional_accession":[]},"is_claimable":false,"name":"ERK binding protein identification","description":"Identification  of the ERK binding protein in regenerated leg","dates":{"publication":"Thu Mar 07 00:00:00 GMT 2024"},"accession":"PXD050429","cross_references":{"TAXONOMY":["6978"],"pubmed":["38507478"]}}