{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Juntao Yang"],"species":["Homo Sapiens"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0008346000"],"submitter_email":["superyjt79@163.com"],"submitter_affiliation":["Peking Union Medical College"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"pubmed_abstract":["<h4>Purpose</h4>The hippocampus has long been associated with cognition and memory function, the implications of lysine lactylation (Kla), a recently identified post-translational modification (PTM), in the role of the hippocampus remain largely unexplored.<h4>Experimental design</h4>An LC-MS/MS bottom-up proteomics analysis of three human hippocampal tissue samples was applied to profile the lactylation map in human hippocampi under normal physiological conditions.<h4>Results</h4>We identified 2579 quantifiable Class I lactylated sites in 853 proteins, of which contained four types of modification motifs. Cellular localization analysis implies that a majority of lactylated proteins were distributed in the cytoplasm. Functional enrichment analysis showed that lactylated proteins were mainly involved in energy metabolic pathways. In addition, we found that the lactylation on histones exhibits a certain degree of conservation across different tissues. Compared with previously reported lactylation databases, 213 lactylated proteins were identified for the first time in this study.<h4>Conclusion and clinical relevance</h4>The first global lactylated proteins atlas of human hippocampi was reported in this study. Our work provides a reliable foundation for further research on lactylation in the hippocampus under physiological conditions."],"pubmed_title":["Global Profiling of Protein Lactylation in Human Hippocampi."],"pubmed_authors":["Shi Chun-Mei CM, Wang Qiao-Chu QC, Li Xiao-Lu XL, Yang Ye-Hong YH, Tang Xiao-Yue XY, Wu Yue Y, Ding Tao T, Zhang Xu-Tong XT, Zhang Zhi-Yi ZY, Han Ron R, Kong Jie J, Liu Jiang-Feng JF, Yang Jun-Tao JT"],"pubmed_title_synonyms":["Protein Gene Products, Human, Gene Proteins, protein polypeptide chains, human being, native protein, Man (Taxonomy), natural protein, polypeptide chain, Homo sapiens, protein complex, Modern Man, Protein, Gene Products, Proteins, Gene, Modern., proteins, protein, protein aggregate, protein-containing complex, man, Man, human"],"description_synonyms":["biochemical pathways, liquid chromatography tandem mass spectroscopy, Neurological, Metabolic Networks, Networks, Post Translational Amino Acid Modification, Metabolic Process, posttranslational modification, Disorders, Activity, Lysine Hydrochloride, determination, Laboratory, Metabolic Concepts, Protein Processing, Molecular Biologies, Long Term, Protoplasm, Biological Processes, Biological Phenomenon, Lysine Acetate, Bio Informatics, diseases, Roles, Neurologic Disorders, Biological, Concepts, 2, diseases and disorders, establishment and maintenance of substrate location, Metabolism Concept, Research Activity, Phenomenon, Laboratory Research, Effect, Formal Social Controls, L Lysine, Priorities, Post-Translational Protein, average, posttranslational amino acid modification, human disease, LCMSMS, Man (Taxonomy), Biology, K, Post-Translational, catabolism, Personnel, epsilon-diaminocaproic acid, Pathways, Oncogeneses, metabolic process resulting in cell growth, proteins, Posttranslational Protein Processing, Bio-Informatic, Computational, Social, LYS, Bio-Informatics, Lysin, Role Concepts, biotransformation, Homo sapiens disease, Research Priority, transcription from bacterial-type RNA polymerase promoter, Catabolism, Computational Molecular Biologies, Long-Term Effects, Nervous System Diseases, LC-MS2, establishment and maintenance of substance location, Post-Translational Modification, Pathway, Process, Cytoplasms, metabolism resulting in cell growth, Modern, Modifications, Biologies, LC-MS/MS, Longterm Effect, Research Priorities, Metabolic Network, Computational Molecular, single organism localization, Post Translational Modifications, Role Concept, Computational Molecular Biology, Diseases, lysine, Role, secretion, Biological Process, Research and Development, Biologic Phenomena, Clinical Investigator, PTM, Bioinformatic, Processing, Control, Researcher, alpha, Controls, human, class, Activities, disease, Amino Acid Modification, Oncogenesis, post-translational modification, liquid chromatography-tandem mass spectroscopy, bacterial transcription, Posttranslational Modifications, Regulation, Posttranslational Modification, establishment and maintenance of cellular component location, Regulations, other disease, Tumorigeneses, Nerve Diseases, human being, Post-Translational Protein Modifications, Effects, Processes, Gene, Network, Metabolic Processes, LC-MS-MS, Posttranslational, Human, Homo sapiens, Metabolism, LC-MSMS, Post Translational Modification, establishment and maintenance of position, Gene Products, disease or disorder, Survey, Post-Translational Modifications, Lysine, Metabolism Phenomena, Man, Post Translational, Modification, study, Nervous System, Clinical, Research, Longterm, Investigators, Clinical Investigators, Metabolic Concept, posttranslational protein modification, Long-Term, Neurological Disorder, man, Probabilities, Protein Modifications, non-neoplastic, Post-Translational Amino Acid Modification, Neurologic, Posttranslational Amino Acid Modification, Disorder, Neurological Disorders, Posttranslational Protein, disorder, Long-Term Effect, species, Development and Research, Biologic, Disease, Molecular Biology, Neurologic Disorder, degradation, Social Controls., Formal Social Control, Investigator, Proteins, disorders, Post-Translational Protein Modification, medical condition, function, Tumorigenesis, Nervous System Disorder, Bioinformatics, Concept, Metabolic Phenomena, Metabolism Concepts, LC/MS/MS, Priority, Social Control, Acetate, Protein, chemical analysis, Long Term Effects, Phenomena, Research Activities, Nervous System Disease, condition, establishment and maintenance of localization, Protein Modification, L-Lysine, metabolism, Metabolic Pathways, Data Base, Metabolic Phenomenon, Survey Personnel, multicellular organism metabolic process, biodegradation, Metabolic, Post Translational Protein Processing, Carcinogeneses, single-organism localization, post-translational amino acid modification, Longterm Effects, Protein Gene Products, Nervous system diseases, Gene Proteins, Post Translational Protein Modification, single-organism metabolic process, localisation, socioeconomic factors, Modern Man, Protoplasms, Post-Translational Protein Processing, Nervous System Disorders, liquid chromatography tandem mass spectrometry, Metabolic Pathway, Researchers, regulation, assay, 6-diaminohexanoic acid, Enisyl, Anabolism"],"pubmed_abstract_synonyms":["Experimental Designs, liquid chromatography tandem mass spectroscopy, Metabolic Networks, Networks, Cognitive Function, Post Translational Amino Acid Modification, Research Technique, posttranslational modification, Problem Formulations, degree (angle), Adjustments, Activity, Lysine Hydrochloride, determination, methionine aminopeptidase activity, Ammon horn fields, Laboratory, Design, Error Sources, Technic, Foundation, Protein Processing, Long Term, Protoplasm, Histone H2b, Techniques, intracellular localization, Histone H2a, Lysine Acetate, Formations, Roles, Method, Concepts, 2, Research Activity, Effect, Laboratory Research, peptidase M activity, L Lysine, Experimental Design, adenomas, Priorities, Post-Translational Protein, Group, average, portion of tissue, rabGAPLP, single organism cellular localization, posttranslational amino acid modification, L-methionine aminopeptidase activity, LCMSMS, Man (Taxonomy), K, Post-Translational, C1, Matched Group, Tissue, Designs, epsilon-diaminocaproic acid, Matched, Clinical Importance, RabGAP-5, localization within cell, Pathways, Groups, proteins, experimental design, Posttranslational Protein Processing, Ammons Horn, Cognitions, LYS, Ammons horn, Functions, RUSC3, Lysin, Reporting, Role Concepts, Research Techniques, Histone H5, Histone H4, Histone H7, Research Priority, Long-Term Effects, Histone H1, Data Reporting, Histone H3, LC-MS2, ammon gyrus, Post-Translational Modification, Pathway, Ammon, Research Technic, formatio hippocampi, Research Methodology, Cytoplasms, Modern, Modifications, LC-MS/MS, MYH-associated polyposis, autosomal recessive familial adenomatous polyposis, Longterm Effect, Research Proposals, Maps, Ammon Horn, Research Priorities, hippocampus proper, Metabolic Network, Insight, Significance, seahorse, Research Proposal, Subiculums, Post Translational Modifications, Experimental, Role Concept, Hippocampal, lysine, Role, tissue portion, major hippocampus, Ammon's Horn, Technics, simple tissue, Problem Formulation, Problem, Subiculum, autosomal recessive, cellular localisation, Research and Development, RUTBC3, Ammon's, Ammon's horn, PTM, Processing, Relevance, alpha, establishment and maintenance of cellular localization, human, class, RABGAP5, Atlases, Formulations, Activities, primal cortex, Amino Acid Modification, post-translational modification, liquid chromatography-tandem mass spectroscopy, multiple colorectal, Posttranslational Modifications, Data Adjustments, Posttranslational Modification, human being, Post-Translational Protein Modifications, establishment and maintenance of localization in cell or cell membrane, Effects, ammon horn, Matched Groups, Importance, Gene, Scoring Method, Network, LC-MS-MS, Posttranslational, Human, Adjustment, Homo sapiens, Scoring Methods, Sources, LC-MSMS, Post Translational Modification, Gene Products, Post-Translational Modifications, Lysine, Clinical Significance, Cornu Ammonis, Technique, Man, familial adenomatous polyposis, Post Translational, MAP, Histone H3.3, Hippocampus, Modification, study, Methodology, Clinical, Scoring, single-organism cellular localization, Research, Longterm, Proposals, familial adenomatous polyposis 2, posttranslational protein modification, Long-Term, hippocampus major, man, Research Strategy, Cognitive Functions, Protein Modifications, autosomal recessive multiple colorectal adenomas, Post-Translational Amino Acid Modification, Posttranslational Amino Acid Modification, Error Source, Posttranslational Protein, Long-Term Effect, Development and Research, Strategies, Horn, Cornu ammonis, MUTYH-Associated Polyposis, Proper, Proteins, Hippocampus Propers, Post-Translational Protein Modification, Hippocampal Formation, Formulation, function, Histone, cognitive function, Concept, Research Strategies, Insights, LC/MS/MS, archipallium, Priority, Acetate, chemical analysis, Protein, Long Term Effects, Research Activities, Protein Modification, L-Lysine, Metabolic Pathways, Hippocampus Proper, Proposal, Methods, cornu ammonis, hippocampus proprius, Propers, Hippocampus Proper., Metabolic, Post Translational Protein Processing, Source, Function, Research Designs, CNS - Brain - Hippocampus (MMHCC), Research Technics, arc degree, MYH-Associated Polyposis, Cognitive, Histone H1(s), post-translational amino acid modification, Longterm Effects, Protein Gene Products, Gene Proteins, Data Adjustment, hippocampus, Post Translational Protein Modification, socioeconomic factors, Error, Data, Modern Man, Protoplasms, Post-Translational Protein Processing, liquid chromatography tandem mass spectrometry, Metabolic Pathway, MAP syndrome, assay, 6-diaminohexanoic acid, Strategy, Hippocampal Formations, Enisyl, Formation, FAP2, colorectal adenomatous polyposis"],"name_synonyms":["Protein Gene Products, Human, Gene Proteins, protein polypeptide chains, human being, native protein, Man (Taxonomy), natural protein, polypeptide chain, Homo sapiens, protein complex, Modern Man, Protein, Gene Products, Proteins, Gene, Modern., proteins, protein, protein aggregate, protein-containing complex, man, Man, human"],"additional_accession":[]},"is_claimable":false,"name":"Global profiling of protein lactylation in Human hippocampi","description":"Lysine lactylation (Kla) is a novel posttranslational modification, playing important roles in numerous biological processes, including transcription, metabolism, tumorigenesis and nervous system diseases. Using liquid chromatography-tandem mass spectrometry (LC-MS/MS), researchers have identified lactylation in many human organs and other species, but no research on lactylation in human hippocampi has been reported. In this study, we performed global profiling of lactylation in human hippocampi under normal physiological conditions, and we identified 2579 Class I (localization probabilities > 0.75) lactylated sites in 853 proteins. Bioinformatics analysis showed that lactylated proteins were mainly located in the cytoplasm and involved in metabolic pathways and some neurological diseases. Compared with those reported lactylation databases, 434 lactylated proteins were identified for the first time in this study. Our work expands the database on human lactylation and helps advance the study on lactylation function and regulation under physiological and pathological conditions.","dates":{"publication":"Fri Mar 08 00:00:00 GMT 2024"},"accession":"PXD050470","cross_references":{"TAXONOMY":["9606"],"pubmed":["39610256"]}}