{"database":"iProX","file_versions":[],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Xue Li"],"species":["Homo Sapiens"],"full_dataset_link":["http://www.iprox.org/page/project.html?id=IPX0009776000"],"submitter_email":["18504292075@163.com"],"submitter_affiliation":["Clinical Medicine Research Institute"],"sample_protocol":[""],"repository":["iProX"],"data_protocol":[""],"pubmed_abstract":["The inhibitory effects of the tumor necrosis factor-α (TNF-α) antibody infliximab (IFX) on colitis are well established. Since IFX dosing is weight-based and associated with various side effects, there is a growing interest in identifying combination therapies that can enhance its efficacy, particularly in overweight inflammatory bowel disease (IBD) patients, to maximize the anti-inflammatory effect while minimizing the required dose. Our research revealed that overweight IBD patients present decreased vitamin D levels in the intestinal epithelium alongside elevated TNF-α levels. In mice fed a high-fat diet (HFD) for four weeks, treatment with the vitamin D analog palicalcitol (PAL) reduced lipid synthesis and TNF-α production in intestinal epithelial cells (IECs). In a 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced experimental colitis model, PAL treatment mitigated TNF-α-induced damage to the intestinal epithelial barrier and reduced the activation of Th1 and Th17 cells in the lamina propria, thereby reducing colitis development in HFD-fed mice. Notably, the combination of IFX and PAL was more effective than IFX alone in treating colitis in these mice. Overall, our findings suggest that vitamin D inhibits TNF-α production by reducing lipid synthesis in IECs, thereby enhancing IFX therapy in overweight IBD patients."],"pubmed_title":["Vitamin D enhances the therapeutic effect of TNF-α antibodies through lipid metabolism in overweight IBD patients."],"pubmed_authors":["Yu Wei W, Huang Pengpeng P, Jin Yanling Y, Wu Fang F, Zhang Cuiping C, Jing Lili L, Chen Ying Y, Xu Han H, Xiong Jiapin J, Zhang Rong R, Zhao Ke K, Li Xue X"],"additional_accession":[]},"is_claimable":false,"name":"Vitamin D enhances the therapeutic effect of TNF-α antibody by lipid metabolism in overweight IBD","description":"The colonic mucosal proteins from HFD and HFD+PAL treated mice were lysed using RIPA buffer, and protein concentration was quantified by BCA assay.","dates":{"publication":"Sun Sep 22 00:00:00 GMT+01:00 2024"},"accession":"PXD056116","cross_references":{"TAXONOMY":["9606"],"pubmed":["40285831"]}}